smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICON10.17238/ISSN2223-2524.2018.4.24smjournal-138Research ArticleСПОРТИВНАЯ ГЕНЕТИКАSPORTS GENETICSГенетические детерминанты устойчивости к гипоксии как один из факторов успешности в единоборствахGenetic determinants of resistance to hypoxia as one of the success factors in martial artsБондареваЭ. А.BondarevaE. A.bondareva.e@gmail.comШаройкоМ. В.ScharoikoM. V.noemail@neicon.ruТуроваЕ. А.TurovaE. A.noemail@neicon.ruФГБОУ ВО Московский государственный университет имени М.В. Ломоносова, Научно-исследовательский институт и Музей антропологии, Правительство РФRussian FederationГАУЗ Московский научно-практический центр медицинской реабилитации, восстановительной и спортивной медицины, Департамент здравоохранения г. МосквыRussian Federation201821082020845458Copyright © Бондарева Э.А., Шаройко М.В., Турова Е.А., 20202020Бондарева Э.А., Шаройко М.В., Турова Е.А.Bondareva E.A., Scharoiko M.V., Turova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/138

Цель исследования: изучение генетического отбора по гену EPAS1 (G/A, rsl867785) в группе спортсменов, занимающихся греко-римской борьбой, и достигших различного уровня спортивного мастерства. Материалы и методы: проведено генетическое обследование 79 спортсменов, занимающихся греко-римской борьбой (от 7 до 25 лет)и 92 неспортсменов (от 7 до 30 лет). Результаты: частота встречаемости А-аллеля, ассоциированного с лучшей адаптацией к гипоксическим условиям, выше в группе борцов (EPAS1*GG - 27,8 %EPAS1*AG - 67,1 % и EPAS1*AA - 5,1 % против EPAS1*GG - 56,5 % EPAS1*AG - 35,9 % и EPAS1*AA - 7,6 % х2 = 16,7 р = 0,0002). Также отбор носителей А-аллеля усиливается при повышении уровня спортивного мастерства обследованных. Увеличение частоты встречаемости минорного А-аллеля в подгруппе борцов греко-римского стиля, прошедших многолетний профессиональный отбор и демонстрирующих высокие спортивные результаты, свидетельствует об их преимуществе по сравнению с носителями G-аллеля. Выводы: G/A-полиморфизм EPAS1 может использоваться при отборе и прогнозе успешности в греко-римской борьбе.

Objective: to study the genetic selection of the EPAS1 gene (G/А, rsl867785) in a group of athletes involved in Greco-Roman wrestling with different levels of sportsmanship. Materials and methods: the genetic examination of 79 male athletes (from 7 to 25 years old) involved in Greco-Roman wrestling and 92 controls (from 7 to 30 years old) was performed. Results: the frequency of A-allele associated with better adaptation to hypoxic conditions was higher in the group of wrestlers (EPAS1*GG - 27.8% EPAS1*AG - 67.1% and EPAS1*AA - 5.1% against EPAS1*GG - 56.5% EPAS1*AG - 35.9% and EPAS1 *AA - 7.6 %. x2 = 16.7 p = 0.0002). The frequency of A-allele carriers increased with increasing level of sportsmanship of studied athletes. The increase in the frequency of minor A-allele in the subgroup of Greco-Roman wrestlers testifies to their advantage in comparison with the carriers of G-allele. Conclusions: G/A-polymorphism of the EPAS1 gene can be used in the selection and prediction of sports success in Greco-Roman wrestling.

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The authors declare that there are no conflicts of interest present.