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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">smjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Спортивная медицина: наука и практика</journal-title><trans-title-group xml:lang="en"><trans-title>Sports medicine: research and practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2524</issn><issn pub-type="epub">2587-9014</issn><publisher><publisher-name>NEICON</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.17238/ISSN2223-2524.2019.2.5</article-id><article-id custom-type="elpub" pub-id-type="custom">smjournal-154</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИОЛОГИЯ И БИОХИМИЯ СПОРТА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SPORTS PHYSIOLOGY AND BIOCHEMISTRY</subject></subj-group></article-categories><title-group><article-title>Анализ гипотез развития синдрома перетренированности</article-title><trans-title-group xml:lang="en"><trans-title>Development of overtraining syndrome: survey of hypotheses</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5945-0722</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дикунец</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dikunets</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дикунец Марина Александровна, ведущий научный сотрудник лаборатории проблем спортивной подготовки, к.х.н.  </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Marina A. Dikunets, Ph.D. (Chemistry), Leading Researcher of the Laboratory of Problems of Athletic Performance </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1064-3283</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудко</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudko</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дудко Григорий Алексеевич, старший научный сотрудник лаборатории проблем спортивной подготовки </p><p>г. Москва</p><p>+7 (925) 729-02-75</p></bio><bio xml:lang="en"><p>Grigory A. Dudko, Senior Researcher of the Laboratory of Problems of Athletic Performance </p><p>Moscow</p></bio><email xlink:type="simple">dudko@vniifk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7727-258X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шачнев</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Shachnev</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шачнев Евгений Николаевич, заместитель генерального директора по развитию  </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Evgeniy N. Shachnev, Deputy General Manager for Development </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1184-9694</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мякинченко</surname><given-names>Е. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Myakinchenko</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мякинченко Евгений Борисович, ведущий научный сотрудник лаборатории проблем спортивной подготовки, д.пед.н.  </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Evgeniy B. Myakinchenko, D.Sc. (Education), Leading Researcher of the Laboratory of Problems of Athletic Performance </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1023-5490</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лянг</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyang</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лянг Ольга Викторовна, доцент кафедры госпитальной терапии с курсом клинической лабораторной диагностики, доцент, к.б.н..  </p><p>г. Москва</p></bio><bio xml:lang="en"><p>Olga V. Lyang, Ph.D. (Biology), Associate Professor of the Department of Hospital Therapy with Clinical Laboratory Diagnostic Course </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ Федеральный научный центр физической культуры и спорта, Министерство спорта РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Science Center for Physical Culture and Sport</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ООО Научный центр «ЭФиС»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Center «EFiS» LLC</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО Российский университет дружбы народов, Министерство науки и высшего образования РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>People’s Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>08</month><year>2020</year></pub-date><volume>9</volume><issue>2</issue><fpage>5</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дикунец М.А., Дудко Г.А., Шачнев Е.Н., Мякинченко Е.Б., Лянг О.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Дикунец М.А., Дудко Г.А., Шачнев Е.Н., Мякинченко Е.Б., Лянг О.В.</copyright-holder><copyright-holder xml:lang="en">Dikunets M.A., Dudko G.A., Shachnev E.N., Myakinchenko E.B., Lyang O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.smjournal.ru/jour/article/view/154">https://www.smjournal.ru/jour/article/view/154</self-uri><abstract><p>В настоящем обзоре представлены современные обобщенные знания по определению, причинам возникновения, симптомам, а также проявлениям синдрома перетренированности у спортсменов. Для изучения синдрома перетренированности необходим анализ биохимических, физиологических, эндокринных, нейрональных и миологических параметров, каждый из которых потенциально вовлечен в понимание метаболических аспектов перетренированности. Развитие синдрома перетренированности объясняется многочисленными гипотезами, каждая из которых имеет свои сильные и слабые стороны. Каждая теория сосредоточена вокруг ключевого параметра, дисбаланс которого может привести к перетренированности в ходе выполнения длительных нагрузок с высокой интенсивностью. Очевидно, что ни один отдельно взятый маркер не может быть использован для диагностических целей. Комплексный подход для объяснения развития синдрома перетренированности обеспечивает теория цитокинов.</p></abstract><trans-abstract xml:lang="en"><p>This review presents current summarized knowledge on definition, causes, symptoms and evidence of overtraining syndrome in athletes. Analysis of biochemical, physiological, endocrine, neuronal and mycological parameters, each of which is potentially involved in understanding of the metabolic aspects of overtraining syndrome, is required to study the latter. The development of overtraining syndrome is explained by numerous hypotheses with their own strengths and weaknesses. Each theory is centered around a key parameter, disbalance of which can lead to overtraining during the execution of long-term high intensity training loads. Obviously none of isolated markers can be used for diagnostic purposes. A comprehensive approach to explain overtraining syndrome development is provided by a theory of cytokines.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>спортсмены</kwd><kwd>спортивная медицина</kwd><kwd>физиология</kwd><kwd>физическая подготовка</kwd><kwd>биохимия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>athletes</kwd><kwd>sports medicine</kwd><kwd>physiology</kwd><kwd>exercise training</kwd><kwd>biochemistry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, Raglin J, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis, and treatment of the over training syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine // Med. Sci. Sports Exerc. 2013. Vol.45, №1. P. 186-205. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation><mixed-citation xml:lang="en">Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, Raglin J, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med. Sci. Sports Exerc. 2013;45(1):186-205. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and the treatment of the overtraining syndrome // Eur. J. Sport Sci. 2006. Vol.6, №1. P. 1-14. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation><mixed-citation xml:lang="en">Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and the treatment of the overtraining syndrome. Eur. J. Sport Sci. 2006;6(1):1-14. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Макарова Г.А., Волков С.Н., Холявко Ю.А., Локтев С.А. Синдром перетренированности у спортсменов (обзор отечественной и зарубежной литературы). 1 часть // Физическая культура, спорт – наука и практика. 2014. №3. С. 29-37.</mixed-citation><mixed-citation xml:lang="en">Makarova GA, Volkov SN, Kholyavko YuA, Loktev SA. Overtraining syndrome in athletes (review of national and foreign literature) Part 1. Physical culture, sport – science and practice. 2014;3:29-37. Russian.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kreher JB, Schwartz JB. Overtraining syndrome: a practical guide//Sports Health. 2012. Vol.4, №2. P. 128-38. DOI: 10.1177/1941738111434406.</mixed-citation><mixed-citation xml:lang="en">Kreher JB, Schwartz JB. Overtraining syndrome: a practical guide. Sports Health. 2012;4(2):128-38. DOI: 10.1177/1941738111434406.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Petibois C, Cazorla G, Poortmans JR, Déléris G. Biochemical aspects of overtraining in endurance sports: a review // Sports Med. 2002. Vol.32, №13. P. 867-78. DOI: 10.2165/00007256-200232130-00005.</mixed-citation><mixed-citation xml:lang="en">Petibois C, Cazorla G, Poortmans JR, Déléris G. Biochemical aspects of overtraining in endurance sports: a review. Sports Med. 2002;32(13):867-78. DOI: 10.2165/00007256-200232130-00005.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Bosquet L, Leger L, Legros P. Blood lactate response to overtraining in male endurance athletes // Eur. J. Appl. Physiol. 2001. Vol.84, №1-2. P. 107-14. DOI: 10.1007/s004210000343.</mixed-citation><mixed-citation xml:lang="en">Bosquet L, Leger L, Legros P. Blood lactate response to overtraining in male endurance athletes. Eur. J. Appl. Physiol. 2001;84(1-2):107-14. DOI: 10.1007/s004210000343.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Snyder AC, Jeukendrup AE, Hesselink MK, Kuipers H, Foster C. A physiological/psychological indicator of over-reaching during intensive training // Int. J. Sports Med. 1993. Vol.14, №1. P. 29-32. DOI: 10.1055/s-2007-1021141.</mixed-citation><mixed-citation xml:lang="en">Snyder AC, Jeukendrup AE, Hesselink MK, Kuipers H, Foster C. A physiological/psychological indicator of over-reaching during intensive training. Int. J. Sports Med. 1993;14(1):29-32. DOI: 10.1055/s-2007-1021141.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and treatment of the overtraining syndrome // Eur. J. Sport Sci. 2006. Vol.6, №1. P. 1-14. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation><mixed-citation xml:lang="en">Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and treatment of the overtraining syndrome. Eur. J. Sport Sci. 2006;6(1):1-14. DOI: 10.1249/MSS.0b013e318279a10a.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Newsholme EA. Biochemical mechanisms to explain immunosuppression in well-trained and overtrained athletes // Int. J. Sports Med. 1994. Vol.15, №3. P. 142-7. DOI: 10.1055/s-2007-1021129.</mixed-citation><mixed-citation xml:lang="en">Newsholme EA. Biochemical mechanisms to explain immunosuppression in well-trained and overtrained athletes. Int. J. Sports Med. 1994;15(3):142-7. DOI: 10.1055/s-2007-1021129.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Blomstrand E, Hassmen P, Ek S, Ekblom B, Newsholme EA. Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise // Acta Physiol. Scand. 1997. Vol.159, №1. P. 41-9. DOI: 10.1046/j.1365-201X.1997.547327000.x.</mixed-citation><mixed-citation xml:lang="en">Blomstrand E, Hassmen P, Ek S, Ekblom B, Newsholme EA. Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise. Acta Physiol. Scand. 1997;159(1):41-9. DOI: 10.1046/j.1365-201X.1997.547327000.x.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hiscock N, Pedersen BK. Exercise-induced immunodepression – plasma glutamine is not the link // J. Appl. Physiol. 2002. Vol.93. P. 813-22. DOI: 10.1152/japplphysiol.00048.2002.</mixed-citation><mixed-citation xml:lang="en">Hiscock N, Pedersen BK. Exercise-induced immunodepression – plasma glutamine is not the link. J. Appl. Physiol. 2002;93:813- 22. DOI: 10.1152/japplphysiol.00048.2002.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Parry-Billings M, Budgett R, Koutedakis Y, Blomstrand E, Brooks S, Williams C, Calder PC, Pilling S, BaigrieR, Newsholme EA. Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system // Med. Sci. Sports Exerc. 1992. Vol.24, №12. P. 1353-8. DOI: 10.1249/00005768-199212000-00008.</mixed-citation><mixed-citation xml:lang="en">Parry-Billings M, Budgett R, Koutedakis Y, Blomstrand E, Brooks S, Williams C, Calder PC, Pilling S, Baigrie R, Newsholme EA. Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system. Med. Sci. Sports Exerc. 1992;24(12):1353-8. DOI: 10.1249/00005768-199212000-00008.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pyne DB, McDonald WA, Gleeson M, Flanagan A, Clancy RL, Fricker PA. Mucosal immunity, respiratory illness, and competitive performance in elite swimmers // Med. Sci. Sports Exerc. 2000. Vol.33, №3. P. 348-53.</mixed-citation><mixed-citation xml:lang="en">Pyne DB, McDonald WA, Gleeson M, Flanagan A, Clancy RL, Fricker PA. Mucosal immunity, respiratory illness, and competitive performance in elite swimmers. Med. Sci. Sports Exerc. 2000;33(3):348-53.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Calder PC, Newsholme EA. Polyunsatturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production // Clin. Sci. 1992. Vol.82, №6. P. 695-700.</mixed-citation><mixed-citation xml:lang="en">Calder PC, Newsholme EA. Polyunsatturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin. Sci. 1992;82(6):695-700.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Aïssa-Benhaddad A, Bouix D, Khaled S, Micallef JP, Mercier J, Bringer J, Brun JF. Early hemorheologic aspects of overtraining in elite athletes // Clin. Hemorheol. Microcirc. 1999. Vol.20, №2. P. 117-25.</mixed-citation><mixed-citation xml:lang="en">Aïssa-Benhaddad A, Bouix D, Khaled S, Micallef JP, Mercier J, Bringer J, Brun JF. Early hemorheologic aspects of overtraining in elite athletes. Clin. Hemorheol. Microcirc. 1999; 20(2):117-25.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann M, Gastmann U, Lormes W. Influence of intensified training on neuroendocrine axes regulation: possible impact of tissue markers like leptin, inhibin B, vitamin D // «3rd Colloque Biologie de l’exercice musculaire». 2001. P. 51.</mixed-citation><mixed-citation xml:lang="en">Lehmann M, Gastmann U, Lormes W. Influence of intensified training on neuroendocrine axes regulation: possible impact of tissue markers like leptin, inhibin B, vitamin D. «3rd Colloque Biologie de l’exercice musculaire». 2001:51.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ishigaki T, Koyama K, Tsujita J, Tanaka N, Hori S, Oku Y. Plasma leptin levels of elite endurance runners after heavy endurance training // J. Physiol. Anthropol. Appl. Human Sci. 2005. Vol.24, №6. P. 573-8. DOI: 10.2114/jpa.24.573.</mixed-citation><mixed-citation xml:lang="en">Ishigaki T, Koyama K, Tsujita J, Tanaka N, Hori S, Oku Y. Plasma leptin levels of elite endurance runners after heavy endurance training. J. Physiol. Anthropol. Appl. Human Sci. 2005;24(6):573-8. DOI: 10.2114/jpa.24.573.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Noland RC, Baker JT, Boudreau SR, Kobe RW, Tanner CJ, Hickner RC, McCammon MR, Houmard JA. Effect of intense training on plasma leptin in male and female swimmers // Med. Sci. Sports Exerc. 2001. Vol.33, №2. P. 227-31. DOI: 10.1097/00005768-200102000-00009.</mixed-citation><mixed-citation xml:lang="en">Noland RC, Baker JT, Boudreau SR, Kobe RW, Tanner CJ, Hickner RC, McCammon MR, Houmard JA. Effect of intense training on plasma leptin in male and female swimmers. Med. Sci. Sports Exerc. 2001;33(2):227-31. DOI: 10.1097/00005768-200102000-00009.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise // Br. J. Sports Med. 2010. Vol.44, №9. P. 620-30. DOI: 10.1136/bjsm.2008.046151.</mixed-citation><mixed-citation xml:lang="en">Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br. J. Sports Med. 2010;44(9):620-30. DOI: 10.1136/bjsm.2008.046151.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Cleare AJ, O’Keane V, Miell J. Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion // Clin. Endocrinol. 2001. Vol.55, №1. P. 113-9. DOI: 10.1046/j.1365-2265.2001.01341.x.</mixed-citation><mixed-citation xml:lang="en">Cleare AJ, O’Keane V, Miell J. Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Clin. Endocrinol. 2001;55(1):113-9. DOI: 10.1046/j.1365-2265.2001.01341.x.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">McKenzie DC. Markers of excessive exercise // Can. J. Appl. Physiol. 1999. Vol.24, №1. P. 66-73. DOI: 10.1139/h99-007.</mixed-citation><mixed-citation xml:lang="en">McKenzie DC. Markers of excessive exercise. Can. J. Appl. Physiol. 1999;24(1):66-73. DOI: 10.1139/h99-007.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Saxton JM, Donnelly AE, Roper HP. Indices of free-radicalmediated damage following maximum voluntary eccentric and concentric muscular work // Eur. J. Appl. Physiol. Occup. Physiol. 1994. Vol.68, №3. P. 189-93. DOI: 10.1007/BF00376765.</mixed-citation><mixed-citation xml:lang="en">Saxton JM, Donnelly AE, Roper HP. Indices of freeradical-mediated damage following maximum voluntary eccentric and concentric muscular work. Eur. J. Appl. Physiol. Occup. Physiol. 1994;68(3):189-93. DOI: 10.1007/BF00376765.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Tiidus PM. Radical species in inflammation and overtraining // Can. J. Physiol. Pharmacol. 1998. Vol.76, №5. P. 533-8.</mixed-citation><mixed-citation xml:lang="en">Tiidus PM. Radical species in inflammation and overtraining. Can. J. Physiol. Pharmacol. 1998;76(5):533-8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, Mitrakou A, Mastorakos G, Papassotiriou I, Taxildaris K, Kouretas D. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis // Free Radic. Biol. Med. 2007. Vol.43, №6. P. 901-10. DOI: 10.1016/j.freeradbiomed.2007.05.022.</mixed-citation><mixed-citation xml:lang="en">Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, Mitrakou A, Mastorakos G, PapassotiriouI, Taxildaris K, Kouretas D. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radic. Biol. Med. 2007;43(6):901-10. DOI: 10.1016/j.freeradbiomed.2007.05.022.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts // Proc. Natl. Acad. Sci. U.S.A. 2003. Vol.100, №13. P. 7996-8001. DOI: 10.1073/pnas.1332551100.</mixed-citation><mixed-citation xml:lang="en">Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc. Natl. Acad. Sci. U.S.A. 2003;100(13):7996-8001. DOI: 10.1073/pnas.1332551100.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Halson SL, Jeukendrup AE. Does overtraining exist? An analysis of overreaching and overtraining research // Sports Med. 2004. Vol.34, №14. P. 967-81. DOI: 10.2165/00007256-200434140-00003.</mixed-citation><mixed-citation xml:lang="en">Halson SL, Jeukendrup AE. Does overtraining exist? An analysis of overreaching and overtraining research. Sports Med. 2004;34(14):967-81. DOI: 10.2165/00007256-200434140-00003.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Carter JR, Ray CA. Sympathetic neural adaptations to exercise training in humans // Auton. Neurosci. 2015. Vol. 188. P. 36-43. DOI: 10.1016/j.autneu.2014.10.020.</mixed-citation><mixed-citation xml:lang="en">Carter JR, Ray CA. Sympathetic neural adaptations to exercise training in humans. Auton. Neurosci. 2015;188:36-43. DOI: 10.1016/j.autneu.2014.10.020.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Christensen NJ, Galbo H. Sympathetic nervous activity during exercise // Ann. Rev. Physiol. 1983. Vol.45. P. 139-53. DOI: 10.1146/annurev.ph.45.030183.001035.</mixed-citation><mixed-citation xml:lang="en">Christensen NJ, Galbo H. Sympathetic nervous activity during exercise. Ann. Rev. Physiol. 1983;45:139-53. DOI: 10.1146/annurev.ph.45.030183.001035.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kaji Y, Ariyoshi K, Tsuda Y, Kanaya S, Fujino T, Kuwabara H. Quantitative correlation between cardiovascular and plasma epinephrine response to mental stress // Eur. J. Appl. Physiol. 1989. Vol.59, №3. P. 221-6. DOI: 10.1007/BF02386191.</mixed-citation><mixed-citation xml:lang="en">Kaji Y, Ariyoshi K, Tsuda Y, Kanaya S, Fujino T, Kuwabara H. Quantitative correlation between cardiovascular and plasma epinephrine response to mental stress. Eur. J. Appl. Physiol. 1989;59(3):221-6. DOI: 10.1007/BF02386191.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Hynynen A, Uusitalo A, Konttinen N, Rusko H. Heart rate variability during night sleep and after awakening in overtrained athletes // Med. Sci. Sports Exerc. 2006. Vol.38, №2. P. 313-7. DOI: 10.1249/01.mss.0000184631.27641.b5.</mixed-citation><mixed-citation xml:lang="en">Hynynen A, Uusitalo A, Konttinen N, Rusko H. Heart rate variability during night sleep and after awakening in overtrained athletes. Med. Sci. Sports Exerc. 2006;38(2):313-7. DOI: 10.1249/01.mss.0000184631.27641.b5.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pichot V, Roche F, Gaspoz JM, Enjolras F, Antoniadis A, Minini P, Costes F, Busso T, Lacour JR, Barthélémy JC. Relation between heart rate variability and training load in middle distance runners // Med. Sci. Sports Exerc. 2000. Vol.32, №10. P. 1729-36.</mixed-citation><mixed-citation xml:lang="en">Pichot V, Roche F, Gaspoz JM, Enjolras F, Antoniadis A, Minini P, Costes F, Busso T, Lacour JR, Barthélémy JC. Relation between heart rate variability and training load in middle distance runners. Med. Sci. Sports Exerc.2000;32(10):1729-36.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Kindermann W. Overtraining – expression of a disturbed autonomic regulation // Dtsch. Z. Sportmed. 1986. Vol.37. P. 238-45. DOI: 10.2165/00007256-199520040-00004.</mixed-citation><mixed-citation xml:lang="en">Kindermann W. Overtraining – expression of a disturbed autonomic regulation. Dtsch. Z. Sport. med. 1986;37:238-45. DOI: 10.2165/00007256-199520040-00004.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hooper SL, Mackinnon LT, Gordon RD, Bachmann AW. Hormonal responses of elite swimmers to overtraining // Med. Sci. Sports Exerc. 1993. Vol.25, №6. P. 741-7. DOI: 10.1249/00005768-199306000-00015.</mixed-citation><mixed-citation xml:lang="en">Hooper SL, Mackinnon LT, Gordon RD, Bachmann AW. Hormonal responses of elite swimmers to overtraining. Med. Sci. Sports Exerc. 1993;25(6):741-7. DOI: 10.1249/00005768-199306000-00015.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Lehmann M, Gastmann U, Petersen KG, Bachl N, Seidel A, Khalaf AN, Fischer S, Keul J. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle- and longdistance runners // Br. J. Sports Med. 1992. Vol.26, №4. P. 233-42. DOI: 10.1136/bjsm.26.4.233.</mixed-citation><mixed-citation xml:lang="en">Lehmann M, Gastmann U, Petersen KG, Bachl N, Seidel A, Khalaf AN, Fischer S, Keul J. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle- and long-distance runners. Br. J. Sports Med. 1992;26(4):233-42. DOI: 10.1136/bjsm.26.4.233.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Banfi G, Marinelli M, Roi GS, Agape V. Usefulness of free testosterone/cortisol ratio during a season of elite speed skating athletes // Int. J. Sports Med. 1993. Vol.14, №7. P. 373-9. DOI: 10.1055/s-2007-1021195.</mixed-citation><mixed-citation xml:lang="en">Banfi G, Marinelli M, Roi GS, Agape V. Usefulness of free testosterone/cortisol ratio during a season of elite speed skating athletes. Int. J. Sports Med. 1993;14(7):373-9. DOI: 10.1055/s-2007-1021195.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Banfi G, Dolci A. Free testosterone/cortisol ratio in soccer: usefulness of a categorization of values // J. Sports Med. Phys. Fitness. 2006. Vol.46, №4. P. 611-6.</mixed-citation><mixed-citation xml:lang="en">Banfi G, Dolci A. Free testosterone/cortisol ratio in soccer: usefulness of a categorization of values J. Sports Med. Phys. Fitness. 2006;46(4):611-6.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Vervoorn C, Vermulst LJ, Boelens-Quist AM, Koppeschaar HP, Erich WB, Thijssen JH, de Vries WR. Seasonal changes in performance and free testosterone: cortisol ratio of elite female rowers // Eur. J. Appl. Physiol. Occup. Physiol. 1992. Vol.64, №1. P. 14-21. DOI: 10.1007/BF00376433.</mixed-citation><mixed-citation xml:lang="en">Vervoorn C, Vermulst LJ, Boelens-Quist AM, Koppeschaar HP, Erich WB, Thijssen JH, de Vries WR. Seasonal changes in performance and free testosterone: cortisol ratio of elite female rowers. Eur. J. Appl. Physiol. Occup. Physiol. 1992;64(1):14-21. DOI: 10.1007/BF00376433.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ribeiro LF, Lima MC, Gobatto CA. Changes in physiological and stroking parameters during interval swims at the slope of the d-t relationship // J. Sci. Med. Sport. 2010. Vol.13, №1. P. 141-5. DOI: 10.1016/j.jsams.2008.10.001.</mixed-citation><mixed-citation xml:lang="en">Ribeiro LF, Lima MC, Gobatto CA. Changes in physiological and stroking parameters during interval swims at the slope of the d-t relationship J. Sci. Med. Sport. 2010;13(1):141-5. DOI: 10.1016/j.jsams.2008.10.001.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA. Physiological responses to successive days of intense training in competitive swimmers // Med. Sci. Sports Exerc. 1988. Vol.20, №3. P. 255-9. DOI: 10.1249/00005768-198806000-00007.</mixed-citation><mixed-citation xml:lang="en">Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA. Physiological responses to successive days of intense training in competitive swimmers. Med. Sci. Sports Exerc. 1988;20(3):255-9. DOI: 10.1249/00005768-198806000-00007.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Meeusen R, Piacentini MF, Busschaert B, Buyse L, De Schutter G, Stray-Gundersen J. Hormonal responses in athletes: the use of a two bout exercise protocol to detect subtle differences in (over)training status // Eur. J. Appl. Physiol. 2004. Vol.91, №2-3. P. 140-6. DOI: 10.1007/s00421-003-0940-1.</mixed-citation><mixed-citation xml:lang="en">Meeusen R, Piacentini MF, Busschaert B, Buyse L, De Schutter G, Stray-Gundersen J. Hormonal responses in athletes: the use of a two bout exercise protocol to detect subtle differences in (over)training status. Eur. J. Appl. Physiol. 2004;91(2-3):140-6. DOI: 10.1007/s00421-003-0940-1.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Cadegiani FA, Kater CE.Hormonal aspects of overtraining syndrome: a systematic review // BMC Sports Sci. Med. Rehabil. 2017. Vol.9, №14. P. 1-15. DOI 10.1186/s13102-017-0079-8.</mixed-citation><mixed-citation xml:lang="en">Cadegiani FA, Kater CE. Hormonal aspects of overtraining syndrome: a systematic review. BMC Sports Sci. Med. Rehabil. 2017;9(14):1-15. DOI 10.1186/s13102-017-0079-8.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Fry RW, Morton AR, Keast D. Overtraining in athletes. An update // Sports Med. 1991. Vol.12, №1. P. 32-65. DOI: 10.2165/00007256-199112010-00004.</mixed-citation><mixed-citation xml:lang="en">Fry RW, Morton AR, Keast D. Overtraining in athletes. An update. Sports Med. 1991;12(1):32-65. DOI: 10.2165/00007256-199112010-00004.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Fry AC, Kraemer WJ, Van-Borselen F, Lynch JM, Marsit JL, Roy EP, Triplett NT, Knuttgen HG. Performance decrements with high-intensity resistance exercise overtraining // Med. Sci. Sports Exerc. 1994. Vol.26, №9. P. 1165-73. DOI: 10.1249/00005768-199409000-00015.</mixed-citation><mixed-citation xml:lang="en">Fry AC, Kraemer WJ, Van-Borselen F, Lynch JM, Marsit JL, Roy EP, Triplett NT, Knuttgen HG. Performance decrements with high-intensity resistance exercise overtraining. Med. Sci. Sports Exerc. 1994;26(9):1165-73. DOI: 10.1249/00005768-199409000-00015.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Robson PJ. Elucidating the unexplained underperformance syndrome in endurance athletes: the interleukin-6 hypothesis // Sports Med. 2003. Vol.33, №10. P. 771-81. DOI: 10.2165/00007256-200333100-00004.</mixed-citation><mixed-citation xml:lang="en">Robson PJ. Elucidating the unexplained underperformance syndrome in endurance athletes: the interleukin-6 hypothesis. Sports Med. 2003;33(10):771-81. DOI: 10.2165/00007256-200333100-00004.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? // Med. Sci. Sports Exerc. 2000. Vol.32, №2. P. 317-31. DOI: 10.1097/00005768-200002000-00011.</mixed-citation><mixed-citation xml:lang="en">Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Med. Sci. Sports Exerc.2000;32(2):317-31. DOI: 10.1097/00005768-200002000-00011.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Smith LL. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? // Sports Med. 2003. Vol.33, №5. P. 347-64. DOI: 10.1097/JSM.0b013e31827ee6d5.</mixed-citation><mixed-citation xml:lang="en">Smith LL. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med. 2003;33(5):347-64. DOI: 10.1097/JSM.0b013e31827ee6d5.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Smith DJ, Roberts D. Effects of high volume and/or intense exercise on selected blood chemistry parameters // Clin. Biochem. 1994. Vol.27, №6. P. 435-40. DOI: 10.1016/0009-9120(94)00055-Z.</mixed-citation><mixed-citation xml:lang="en">Smith DJ, Roberts D. Effects of high volume and/or intense exercise on selected blood chemistry parameters. Clin. Biochem. 1994;27(6):435-40. DOI: 10.1016/0009-9120(94)00055-Z.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Hu M, Lin W. Effects of exercise training on red blood cell production: implications for anemia // Acta Haematol. 2012. Vol.127, №3. P. 156-64. DOI: 10.1159/000335620.</mixed-citation><mixed-citation xml:lang="en">Hu M, Lin W. Effects of exercise training on red blood cell production: implications for anemia. Acta Haematol. 2012;127(3):156-64. DOI: 10.1159/000335620.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Casoni I, Borsetto C, Cavicchi A, Martinelli S, Conconi F. Reduced hemoglobin concentration and red cell hemoglobinization in Italian marathon and ultramarathon runners // Int. J. Sports Med. 1985. Vol.6, №3. P. 176-9. DOI: 10.1055/s-2008-1025835.</mixed-citation><mixed-citation xml:lang="en">Casoni I, Borsetto C, Cavicchi A, Martinelli S, Conconi F. Reduced hemoglobin concentration and red cell hemoglobinization in Italian marathon and ultramarathon runners. Int. J. Sports Med. 1985;6(3):176-9. DOI: 10.1055/s-2008-1025835.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Friman G, Illbäck NG. Acute infection: metabolic responses, effect on performance, interaction with exercise, and myo-carditis // Int. J. Sports Med. 1998. Vol.19, №3. P. 172-82. DOI: 10.1055/s-2007-971990.</mixed-citation><mixed-citation xml:lang="en">Friman G, Illbäck NG. Acute infection: metabolic responses, effect on performance, interaction with exercise, and myocarditis. Int. J. Sports Med. 1998;19(3):172-82. DOI: 10.1055/s-2007-971990.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
