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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">smjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Спортивная медицина: наука и практика</journal-title><trans-title-group xml:lang="en"><trans-title>Sports medicine: research and practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2524</issn><issn pub-type="epub">2587-9014</issn><publisher><publisher-name>NEICON</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47529/2223-2524.2020.3.27</article-id><article-id custom-type="elpub" pub-id-type="custom">smjournal-216</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФИЗИОЛОГИЯ И БИОХИМИЯ СПОРТА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SPORTS PHYSIOLOGY AND BIOCHEMISTRY</subject></subj-group></article-categories><title-group><article-title>Значение физической активности в регуляции противовирусного иммунитета</article-title><trans-title-group xml:lang="en"><trans-title>The importance of physical activity in the regulation of anti-viral immunity</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1178-7534</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ханферьян</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khanferyan</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ханферьян Роман Авакович, профессор, доктор медицинских наук, профессор кафедры иммунологии и аллергологии</p><p>117198, Москва, ул. Миклухо-Маклая, 6. </p></bio><bio xml:lang="en"><p>Roman A. Khanferyan*, D.M.Sci., Professor of the Department of Immunology and Allergology</p><p>6, Miklouho-Maclay str., Moscow, Russia, 117198</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0939-6411</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радыш</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Radysh</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Радыш Иван Васильевич, доктор медицинских наук, зав. кафедрой управления сестринской деятельности медицинского института </p><p>117198, Москва, ул. Миклухо-Маклая, 6. </p></bio><bio xml:lang="en"><p>Ivan V. Radysh, D.M.Sci., Head. Department of Nursing, Medical Institute</p><p>6, Miklouho-Maclay str., Moscow, Russia, 117198</p></bio><email xlink:type="simple">radysh-iv@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суровцев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Surovtsev</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суровцев Виктор Васильевич, зам. директора медицинского института по инновационной работе</p><p>117198, Москва, ул. Миклухо-Маклая, 6. </p></bio><bio xml:lang="en"><p>Viktor V. Surovtsev, Deputy Director of the Medical I, </p><p>6, Miklouho-Maclay str., Moscow, Russia, 117198</p><p> </p></bio><email xlink:type="simple">surovtsev-vv@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2279-648X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростелева</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Korosteleva</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коростелева Маргарита Михайловна, кандидат медицинских наук, старший научный сотрудник </p><p>109240, Москва, Устьинский проезд, 2/14</p></bio><bio xml:lang="en"><p>Margarita M. Korosteleva, Senior Researcher </p><p>35, Lyusinovskaya str., Moscow, Russia, 115093</p></bio><email xlink:type="simple">korostel@bk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0363-9462</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алешина</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleshina</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алешина Ирина Владимировна, научный сотрудник 109240, Москва, Устьинский пр., 2/14</p></bio><bio xml:lang="en"><p>Irina V. Aleshina, researcher </p><p>2/14, Ustyinsky pr., Moscow, Russia, 109240</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАНУ «Всероссийский научно-исследовательский институт молочной промышленности»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>All-Russian Research Institute of the Dairy Industry</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Research Center for Nutrition and Biotechnology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>06</day><month>12</month><year>2020</year></pub-date><volume>10</volume><issue>3</issue><fpage>27</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ханферьян Р.А., Радыш И.А., Суровцев В.В., Коростелева М.М., Алешина И.В., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Ханферьян Р.А., Радыш И.А., Суровцев В.В., Коростелева М.М., Алешина И.В.</copyright-holder><copyright-holder xml:lang="en">Khanferyan R.A., Radysh I.V., Surovtsev V.V., Korosteleva M.M., Aleshina I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.smjournal.ru/jour/article/view/216">https://www.smjournal.ru/jour/article/view/216</self-uri><abstract><p>Обзор литературы посвящен современным данным о влиянии и роли физической активности различной интенсивности в профилактике инфицирования различными респираторными вирусами, гриппом и коронавирусом SARS-CoV-2. Обсуждаются различия по влиянию физической активности различной интенсивности на состояние противовирусного иммунитета, клеточный и цитокиновый ответ при инфицировании респираторными вирусами, влияние физической активности на эффективность вакцинации и роль регулярной физической активности умеренной интенсивности в профилактике инфицирования вирусами у больных с ожирением, избыточной массой тела, диабетом и другими метаболическими нарушениями. Приводятся литературные данные о роли физической активности в профилактике SARS-CoV-2 вирусной инфекции, а также в условиях самоизоляции и карантина.</p></abstract><trans-abstract xml:lang="en"><p>The paper reviews the current data on the effect and role of varying intensity physical activity in the prevention of various respiratory virus infections, including influenza virus and SARS-CoV-2 coronavirus. The paper discusses the effect of varying intensity physical activity on antiviral immunity, cellular and cytokine responses to respiratory virus infections, physical activity influence on vaccination effectiveness and the role of regular moderate intensity physical activity in the prevention of viral infection in patients with obesity, overweight, diabetes and other metabolic disorders. The paper analyzes physical activity role in the prevention of SARS-CoV-2 infection, as well as in the conditions of self-isolation and quarantine.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>физическая активность</kwd><kwd>противовирусный иммунитет</kwd><kwd>цитокины</kwd><kwd>коронавирус</kwd><kwd>физическая активность и профилактика осложнений</kwd></kwd-group><kwd-group xml:lang="en"><kwd>physical activity</kwd><kwd>antiviral immunity</kwd><kwd>cytokines</kwd><kwd>coronavirus</kwd><kwd>physical activity and prevention of complications</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Публикация подготовлена при поддержке программы РУДН «5-100».</funding-statement><funding-statement xml:lang="en">The publication was prepared with the support of the RUDN University “5-100” Program</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Wentz L.M. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201–217. https://doi.org/10.1016/j.jshs.2018.09.009</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Wentz L.M. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201–217. https://doi.org/10.1016/j.jshs.2018.09.009</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кулененков О.С. Фармакология спорта в таблицах и схемах. 2–е изд. М.: Спорт; 2015. 176 с.</mixed-citation><mixed-citation xml:lang="en">Kulenenkov O.S. Pharmacology of sports in tables and diagrams. 2nd ed. Moscow: Sport; 2015. 176 p. (in Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Baetjer A. The effect of muscular fatigue upon resistance. Physiol Rev. 1932;12(3):453–468. https://doi.org/10.1152/physrev.1932.12.3.453</mixed-citation><mixed-citation xml:lang="en">Baetjer A. The effect of muscular fatigue upon resistance. Physiol Rev. 1932;12(3):453–468. https://doi.org/10.1152/physrev.1932.12.3.453</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Horstmann D.M. Acute poliomyelitis: relation of physical activity at the time of onset to the course of the disease. JAMA. 1950;142(4):236–241. https://doi.org/10.1001/jama.1950.02910220016004</mixed-citation><mixed-citation xml:lang="en">Horstmann D.M. Acute poliomyelitis: relation of physical activity at the time of onset to the course of the disease. JAMA. 1950;142(4):236–241. https://doi.org/10.1001/jama.1950.02910220016004</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Levinson S.O., Milzer A., Lewin P. Effect of fatigue, chilling and mechanical trauma on resistance to experimental poliomyelitis. Am J Hygiene 1945;42(2):204–213. https://doi.org/10.1093/oxfordjournals.aje.a119037</mixed-citation><mixed-citation xml:lang="en">Levinson S.O., Milzer A., Lewin P. Effect of fatigue, chilling and mechanical trauma on resistance to experimental poliomyelitis. Am J Hygiene 1945;42(2):204–213. https://doi.org/10.1093/oxfordjournals.aje.a119037</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Weinstein L. Poliomyelitis: a persistent problem. N Engl J Med 1973;288(7):370–372. https://doi.org/10.1056/nejm197302152880714</mixed-citation><mixed-citation xml:lang="en">Weinstein L. Poliomyelitis: a persistent problem. N Engl J Med 1973;288(7):370–372. https://doi.org/10.1056/nejm197302152880714</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Reyes M.P., Lerner A.M. Interferon and neutralizing antibody in sera of exercised mice with Coxsackievirus B–3 myocarditis. Exp Bio Med 1976;151(2):333–338. https://doi.org/10.3181/00379727-151-39204</mixed-citation><mixed-citation xml:lang="en">Reyes M.P., Lerner A.M. Interferon and neutralizing antibody in sera of exercised mice with Coxsackievirus B–3 myocarditis. Exp Bio Med 1976;151(2):333–338.  https://doi.org/10.3181/00379727-151-39204</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ilbäck N.G., Friman G., Beisel W.R., Johnson A.J., Berendt R.F. Modifying effects of exercise on clinical course and biochemical response of the myocardium in influenza and tularemia in mice. Infect Immun 1984;45(2):498–504. https://doi.org/10.1128/iai.45.2.498–504.1984</mixed-citation><mixed-citation xml:lang="en">Ilbäck N.G., Friman G., Beisel W.R., Johnson A.J., Berendt R.F. Modifying effects of exercise on clinical course and biochemical response of the myocardium in influenza and tularemia in mice. Infect Immun 1984;45(2):498–504. https://doi.org/10.1128/iai.45.2.498–504.1984</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Davis J.M., Murphy E.A., McClellan J.L., Carmichael M.D., Gangemi J.D. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol 2008;295(2):R505–R509. https://doi.org/10.1152/ajpregu.90319.2008</mixed-citation><mixed-citation xml:lang="en">Davis J.M., Murphy E.A., McClellan J.L., Carmichael M.D., Gangemi J.D. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol 2008;295(2):R505–R509. https://doi.org/10.1152/ajpregu.90319.2008</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.A., Davis J.M., Carmichael M.D., Gangemi J.D., Ghaffar A., Mayer E.P. Exercise stress increases susceptibility to influenza infection. Brain Behav Immun 2008;22(8):1152–155. https://doi.org/10.1016/j.bbi.2008.06.004</mixed-citation><mixed-citation xml:lang="en">Murphy E.A., Davis J.M., Carmichael M.D., Gangemi J.D., Ghaffar A., Mayer E.P. Exercise stress increases susceptibility to influenza infection. Brain Behav Immun 2008;22(8):1152–155. https://doi.org/10.1016/j.bbi.2008.06.004</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Carson J.A., Van Rooijen N., et al. Benefits of oat beta–glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 2008;294(5):R1593–R1599. https://doi.org/10.1152/ajpregu.00562.2007</mixed-citation><mixed-citation xml:lang="en">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Carson J.A., Van Rooijen N., et al. Benefits of oat beta–glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 2008;294(5):R1593–R1599. https://doi.org/10.1152/ajpregu.00562.2007</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Shi Y., Shi H., Nieman D.C., Hu Q., Yang L., Liu T., et al. Lactic acid accumulation during exhaustive exercise impairs release of neutrophil extracellular traps in mice. Front Physiol. 2019;10:709. https://doi.org/10.3389/fphys.2019.00709</mixed-citation><mixed-citation xml:lang="en">Shi Y., Shi H., Nieman D.C., Hu Q., Yang L., Liu T., et al. Lactic acid accumulation during exhaustive exercise impairs release of neutrophil extracellular traps in mice. Front Physiol. 2019;10:709. https://doi.org/10.3389/fphys.2019.00709</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Chao C.C., Strgar F., Tsang M., Peterson P.K. Effects of swimming exercise on the pathogenesis of acute murine Toxoplasma gondii Me49 infection. Clin Immunol Immunopathol. 1992;62(2):220–226. https://doi.org/10.1016/0090-1229(92)90075-y</mixed-citation><mixed-citation xml:lang="en">Chao C.C., Strgar F., Tsang M., Peterson P.K. Effects of swimming exercise on the pathogenesis of acute murine Toxoplasma gondii Me49 infection. Clin Immunol Immunopathol. 1992;62(2):220–226. https://doi.org/10.1016/0090-1229(92)90075-y</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Davis J.M., Kohut M.L., Colbert L.H., Jackson D.A., Ghaffar A., Mayer E.P. Exercise, alveolar macrophage function, and susceptibility to respiratory infection. J Appl Physiol. 1997;83(5):1461–1466. https://doi.org/10.1152/jappl.1997.83.5.1461</mixed-citation><mixed-citation xml:lang="en">Davis J.M., Kohut M.L., Colbert L.H., Jackson D.A., Ghaffar A., Mayer E.P. Exercise, alveolar macrophage function, and susceptibility to respiratory infection. J Appl Physiol. 1997;83(5):1461–1466. https://doi.org/10.1152/jappl.1997.83.5.1461</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ceddia M.A., Voss E.W., Woods J.A. Intracellular mechanisms responsible for exerciseinduced suppression of macrophage antigen presentation. J Appl Physiol. 2000;88(2):804–810.https://doi.org/10.1152/jappl.2000.88.2.804</mixed-citation><mixed-citation xml:lang="en">Ceddia M.A., Voss E.W., Woods J.A. Intracellular mechanisms responsible for exerciseinduced suppression of macrophage antigen presentation. J Appl Physiol. 2000;88(2):804–810. https://doi.org/10.1152/jappl.2000.88.2.804</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Woods J.A., Ceddia M.A., Kozak C., Wolters B.W. Effects of exercise on the macrophage MHC II response to inflammation. Int J Sports Med. 1997;18(6):483–488. https://doi.org/10.1055/s-2007-972668</mixed-citation><mixed-citation xml:lang="en">Woods J.A., Ceddia M.A., Kozak C., Wolters B.W. Effects of exercise on the macrophage MHC II response to inflammation. Int J Sports Med. 1997;18(6):483–488. https://doi.org/10.1055/s-2007-972668</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Frellstedt L., Waldschmidt I., Gosset P., Desmet C., Pirottin D., Bureau F., et al. Training modifies innate immune responses in blood monocytes and in pulmonary alveolar macrophages. Am J Respir Cell Mol Biol. 2014;51(1):135–142. https://doi.org/10.1165/rcmb.2013-0341oc</mixed-citation><mixed-citation xml:lang="en">Frellstedt L., Waldschmidt I., Gosset P., Desmet C., Pirottin D., Bureau F., et al. Training modifies innate immune responses in blood monocytes and in pulmonary alveolar macrophages. Am J Respir Cell Mol Biol. 2014;51(1):135–142. https://doi.org/10.1165/rcmb.2013-0341oc</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Boehm G.W., Moynihan J.A. Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection. J Appl Physiol. 2001;90(2):678–84. https://doi.org/10.1152/jappl.2001.90.2.678</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Boehm G.W., Moynihan J.A. Prolonged exercise suppresses antigen-specific cytokine response to upper respiratory infection. J Appl Physiol. 2001;90(2):678–84.  https://doi.org/10.1152/jappl.2001.90.2.678</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ceddia M.A., Woods J.A. Exercise suppresses macrophage antigen presentation. J Appl Physiol. 1999;87(6):2253–2258. https://doi.org/10.1152/jappl.1999.87.6.2253</mixed-citation><mixed-citation xml:lang="en">Ceddia M.A., Woods J.A. Exercise suppresses macrophage antigen presentation. J Appl Physiol. 1999;87(6):2253–2258.  https://doi.org/10.1152/jappl.1999.87.6.2253</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Baron R.C., Hatch M.H., Kleeman K., MacCormack J.N. Aseptic meningitis among members of a high school football team. JAMA. 1982;248(14):1724–1727. https://doi.org/10.1001/jama.1982.03330140034028</mixed-citation><mixed-citation xml:lang="en">Baron R.C., Hatch M.H., Kleeman K., MacCormack J.N. Aseptic meningitis among members of a high school football team. JAMA. 1982;248(14):1724–1727. https://doi.org/10.1001/jama.1982.03330140034028</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts J.A. Loss of form in young athletes due to viral infection. BMJ. 1985;290(6465):357–358. https://doi.org/10.1136/bmj.290.6465.357</mixed-citation><mixed-citation xml:lang="en">Roberts J.A. Loss of form in young athletes due to viral infection. BMJ. 1985;290(6465):357–358. https://doi.org/10.1136/bmj.290.6465.357</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts J.A. Viral illnesses and sports performance. Sports Med 1986;3(4):298–303. https://doi.org/10.2165/00007256-198603040-00006</mixed-citation><mixed-citation xml:lang="en">Roberts J.A. Viral illnesses and sports performance. Sports Med 1986;3(4):298–303. https://doi.org/10.2165/00007256-198603040-00006</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sharp J.C.M. Viruses and the athlete. Br J Sports Med 1989;23(1):47–48. https://doi.org/10.1136/bjsm.23.1.47</mixed-citation><mixed-citation xml:lang="en">Sharp J.C.M. Viruses and the athlete. Br J Sports Med 1989;23(1):47–48. https://doi.org/10.1136/bjsm.23.1.47</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Folsom R.W., Littlefield-Chabaud M.A., French D.D., Pourciau S.S., Mistric L., Horohov D.W. Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J. 2001;33(7):664–669. https://doi.org/10.2746/042516401776249417</mixed-citation><mixed-citation xml:lang="en">Folsom R.W., Littlefield-Chabaud M.A., French D.D., Pourciau S.S., Mistric L., Horohov D.W. Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J. 2001;33(7):664–669. https://doi.org/10.2746/042516401776249417</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Parker S., Brukner P., Rosier M. Chronic fatigue syndrome and the athlete. Sports Med Train Rehab. 1996;6(4):269–278. https://doi.org/10.1080/15438629609512057</mixed-citation><mixed-citation xml:lang="en">Parker S., Brukner P., Rosier M. Chronic fatigue syndrome and the athlete. Sports Med Train Rehab. 1996;6(4):269–278. https://doi.org/10.1080/15438629609512057</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez J.L., Cooper M.J., Myers C.A., Cummings J.F., Vest K.G., Russell K.L., et al. Respiratory infections in the U.S. military: recent experience and control. Clin Microbiol Rev 2015;28(3):743–800. https://doi.org/10.1128/cmr.00039–14</mixed-citation><mixed-citation xml:lang="en">Sanchez J.L., Cooper M.J., Myers C.A., Cummings J.F., Vest K.G., Russell K.L., et al. Respiratory infections in the U.S. military: recent experience and control. Clin Microbiol Rev 2015;28(3):743–800. https://doi.org/10.1128/cmr.00039–14</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266 (5604):730–732. https://doi.org/10.1038/266730a0</mixed-citation><mixed-citation xml:lang="en">Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977;266 (5604):730–732. https://doi.org/10.1038/266730a0</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Рылова М.Л. Методы исследования хронического действия вредных факторов в эксперименте. Л.: Медицина; 1964. 148 с.</mixed-citation><mixed-citation xml:lang="en">Rylova M.L. Research methods of the chronic action of harmful factors in the experiment. Leningrad: Medicine; 1964. 148 р. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Каркищенко Н.Н., Уйба В.В., Каркищенко В.Н., Шустов Е.Б. Очерки спортивной фармакологии. Т. 1. Векторы экстраполяции. М., СПб.: Айсинг; 2013. 288 с.</mixed-citation><mixed-citation xml:lang="en">Karkischenko N.N., Uyba V.V., Karkishchenko V.N., Shustov E.B. Essays on sports pharmacology. Vol. 1. Extrapolation vectors. Moscow, St. Petersburg: Aising; 2013. 288 р. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Dawson C., Horvath S. Swimming in small laboratory animals. Med Sci Sports. 1970;2(2):51–78. https://doi.org/10.1249/00005768-197000220-00002</mixed-citation><mixed-citation xml:lang="en">Dawson C., Horvath S. Swimming in small laboratory animals. Med Sci Sports. 1970;2(2):51–78. https://doi.org/10.1249/00005768-197000220-00002</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814–1820. https://doi.org/10.1056/nejmoa1211721</mixed-citation><mixed-citation xml:lang="en">Zaki A.M., van Boheemen S., Bestebroer T.M., Osterhaus A.D., Fouchier R.A. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367(19):1814–1820. https://doi.org/10.1056/nejmoa1211721</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmer P., Schenk A., Kieven M., Holthaus M., Lehmann J., Lövenich L., Bloch W. Exercise induced alterations in NK-cell cytotoxicity-methodological issues and future perspectives. Exerc Immunol Rev. 2017; 23: 66–81.</mixed-citation><mixed-citation xml:lang="en">Zimmer P., Schenk A., Kieven M., Holthaus M., Lehmann J., Lövenich L., Bloch W. Exercise induced alterations in NK-cell cytotoxicity-methodological issues and future perspectives. Exerc Immunol Rev. 2017; 23: 66–81.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Davis J.M., Murphy E.A., McClellan J.L., Carmichael M.D., Gangemi J.D. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol. 2008;295(2):R505–R509. https://doi.org/10.1152/ajpregu.90319.2008</mixed-citation><mixed-citation xml:lang="en">Davis J.M., Murphy E.A., McClellan J.L., Carmichael M.D., Gangemi J.D. Quercetin reduces susceptibility to influenza infection following stressful exercise. Am J Physiol Regul Integr Comp Physiol. 2008;295(2):R505–R509. https://doi.org/10.1152/ajpregu.90319.2008</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.A., Davis J.M., Carmichael M.D., Gangemi J.D., Ghaffar A., Mayer E.P. Exercise stress increases susceptibility to influenza infection. Brain Behav Immun. 2008;22(8):1152–1155. https://doi.org/10.1016/j.bbi.2008.06.004</mixed-citation><mixed-citation xml:lang="en">Murphy E.A., Davis J.M., Carmichael M.D., Gangemi J.D., Ghaffar A., Mayer E.P. Exercise stress increases susceptibility to influenza infection. Brain Behav Immun. 2008;22(8):1152–1155. https://doi.org/10.1016/j.bbi.2008.06.004</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Carson J.A., Van Rooijen N., et al. Benefits of oat beta–glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 2008;294(5):R1593–R1599. https://doi.org/10.1152/ajpregu.00562.2007</mixed-citation><mixed-citation xml:lang="en">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Carson J.A., Van Rooijen N., et al. Benefits of oat beta–glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 2008;294(5):R1593–R1599. https://doi.org/10.1152/ajpregu.00562.2007</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Shi Y., Shi H., Nieman D.C., Hu Q., Yang L., Liu T., et al. Lactic acid accumulation during exhaustive exercise impairs release of neutrophil extracellular traps in mice. Front Physiol. 2019;10:709. https://doi.org/ 10.3389/fphys.2019.00709</mixed-citation><mixed-citation xml:lang="en">Shi Y., Shi H., Nieman D.C., Hu Q., Yang L., Liu T., et al. Lactic acid accumulation during exhaustive exercise impairs release of neutrophil extracellular traps in mice. Front Physiol. 2019;10:709. https://doi.org/ 10.3389/fphys.2019.00709</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Chao C.C., Strgar F., Tsang M., Peterson P.K. Effects of swimming exercise on the pathogenesis of acute murine Toxoplasma gondii Me49 infection. Clin Immunol Immunopathol. 1992;62(2):220–226. https://doi.org/10.1016/0090-1229(92)90075-y</mixed-citation><mixed-citation xml:lang="en">Chao C.C., Strgar F., Tsang M., Peterson P.K. Effects of swimming exercise on the pathogenesis of acute murine Toxoplasma gondii Me49 infection. Clin Immunol Immunopathol. 1992;62(2):220–226. https://doi.org/10.1016/0090-1229(92)90075-y</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Davis J.M., Kohut M.L., Colbert L.H., Jackson D.A., Ghaffar A., Mayer E.P. Exercise, alveolar macrophage function, and susceptibility to respiratory infection. J Appl Physiol. 1997;83(5):1461–1466. https://doi.org/10.1152/jappl.1997.83.5.1461</mixed-citation><mixed-citation xml:lang="en">Davis J.M., Kohut M.L., Colbert L.H., Jackson D.A., Ghaffar A., Mayer E.P. Exercise, alveolar macrophage function, and susceptibility to respiratory infection. J Appl Physiol. 1997;83(5):1461–1466. https://doi.org/10.1152/jappl.1997.83.5.1461</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ceddia M.A., Voss E.W. Jr, Woods J.A. Intracellular mechanisms responsible for exerciseinduced suppression of macrophage antigen presentation. J Appl Physiol. 2000;88(2):804–810. https://doi.org/10.1152/jappl.2000.88.2.804</mixed-citation><mixed-citation xml:lang="en">Ceddia M.A., Voss E.W. Jr, Woods J.A. Intracellular mechanisms responsible for exerciseinduced suppression of macrophage antigen presentation. J Appl Physiol. 2000;88(2):804–810. https://doi.org/10.1152/jappl.2000.88.2.804</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Woods JA, Ceddia MA, Kozak C, Wolters BW. Effects of exercise on the macrophage MHC II response to inflammation. Int J Sports Med 1997;18:483–488.</mixed-citation><mixed-citation xml:lang="en">Woods JA, Ceddia MA, Kozak C, Wolters BW. Effects of exercise on the macrophage MHC II response to inflammation. Int J Sports Med 1997;18:483–488.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Van Rooijen N., Ghaffar A., et al. Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. Am J Physiol Regul Integr Comp Physiol. 2004;287(6):R1354–R1358. https://doi.org/10.1152/ajpregu.00274.2004</mixed-citation><mixed-citation xml:lang="en">Murphy E.A., Davis J.M., Brown A.S., Carmichael M.D., Van Rooijen N., Ghaffar A., et al. Role of lung macrophages on susceptibility to respiratory infection following short-term moderate exercise training. Am J Physiol Regul Integr Comp Physiol. 2004;287(6):R1354–R1358. https://doi.org/10.1152/ajpregu.00274.2004</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Frellstedt L, Waldschmidt I, Gosset P, Desmet C, Pirottin D, Bureau F, et al. Training modifies innate immune responses in blood monocytes and in pulmonary alveolar macrophages. Am J Respir Cell Mol Biol. 2014;51(1):135–142. https://doi.org/10.1165/rcmb.2013-0341oc</mixed-citation><mixed-citation xml:lang="en">Frellstedt L, Waldschmidt I, Gosset P, Desmet C, Pirottin D, Bureau F, et al. Training modifies innate immune responses in blood monocytes and in pulmonary alveolar macrophages. Am J Respir Cell Mol Biol. 2014;51(1):135–142. https://doi.org/10.1165/rcmb.2013-0341oc</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Boehm G.W., Moynihan J.A. Prolonged exercise suppresses antigen–specific cytokine response to upper respiratory infection. J Appl Physiol. 2001;90(2):678–684. https://doi.org/10.1152/jappl.2001.90.2.678</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Boehm G.W., Moynihan J.A. Prolonged exercise suppresses antigen–specific cytokine response to upper respiratory infection. J Appl Physiol. 2001;90(2):678–684. https://doi.org/10.1152/jappl.2001.90.2.678</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Ceddia M.A., Woods J.A. Exercise suppresses macrophage antigen presentation. J Appl Physiol. 1999;87(6):2253–2258. https://doi.org/10.1152/jappl.1999.87.6.2253</mixed-citation><mixed-citation xml:lang="en">Ceddia M.A., Woods J.A. Exercise suppresses macrophage antigen presentation. J Appl Physiol. 1999;87(6):2253–2258. https://doi.org/10.1152/jappl.1999.87.6.2253</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Horstmann D.M. Acute poliomyelitis: relation of physical activity at the time of onset to the course of the disease. JAMA. 1950;142(4):236–241. https://doi.org/10.1001/jama.1950.02910220016004</mixed-citation><mixed-citation xml:lang="en">Horstmann D.M. Acute poliomyelitis: relation of physical activity at the time of onset to the course of the disease. JAMA. 1950;142(4):236–241. https://doi.org/10.1001/jama.1950.02910220016004</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Weinstein L. Poliomyelitis: a persistent problem. N Engl J Med. 1973;288(7):370–371. https://doi.org/10.1056/nejm197302152880714</mixed-citation><mixed-citation xml:lang="en">Weinstein L. Poliomyelitis: a persistent problem. N Engl J Med. 1973;288(7):370–371. https://doi.org/10.1056/nejm197302152880714</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Levinson S.O., Milzer A., Lewin P. Effect of fatigue, chilling and mechanical trauma on resistance to experimental poliomyelitis. Am J Hygiene 1945;42(2):204–213. https://doi.org/10.1093/oxfordjournals.aje.a119037</mixed-citation><mixed-citation xml:lang="en">Levinson S.O., Milzer A., Lewin P. Effect of fatigue, chilling and mechanical trauma on resistance to experimental poliomyelitis. Am J Hygiene 1945;42(2):204–213. https://doi.org/10.1093/oxfordjournals.aje.a119037</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips M., Robinowitz M., Higgins J.R., Boran K.J., Reed T., Virmani R. Sudden cardiac death in Air Force recruits. A 20–year review. JAMA. 1986;256(19):2696–2699. https://doi.org/10.1001/jama.1986.03380190066026</mixed-citation><mixed-citation xml:lang="en">Phillips M., Robinowitz M., Higgins J.R., Boran K.J., Reed T., Virmani R. Sudden cardiac death in Air Force recruits. A 20–year review. JAMA. 1986;256(19):2696–2699. https://doi.org/10.1001/jama.1986.03380190066026</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Drory Y., Kramer M.R., Lev B. Exertional sudden death in soldiers. Med Sci Sports Exerc. 1991;23(2):147–151. https://doi.org/10.1249/00005768-199102000-00001</mixed-citation><mixed-citation xml:lang="en">Drory Y., Kramer M.R., Lev B. Exertional sudden death in soldiers. Med Sci Sports Exerc. 1991;23(2):147–151. https://doi.org/10.1249/00005768-199102000-00001</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C. COVID–19: A tocsin to our aging, unfit, corpulent, and immunodeficient society. J. Sport Health Sci. 2020;9(4):293–301. https://doi.org/10.1016/j.jshs.2020.05.001</mixed-citation><mixed-citation xml:lang="en">Nieman D.C. COVID–19: A tocsin to our aging, unfit, corpulent, and immunodeficient society. J. Sport Health Sci. 2020;9(4):293–301. https://doi.org/10.1016/j.jshs.2020.05.001</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Baron R.C., Hatch M.H., Kleeman K., MacCormack J.N. Aseptic meningitis among members of a high school football team. JAMA. 1982;248(14):1724–1727. https://doi.org/10.1001/jama.248.14.1724</mixed-citation><mixed-citation xml:lang="en">Baron R.C., Hatch M.H., Kleeman K., MacCormack J.N. Aseptic meningitis among members of a high school football team. JAMA. 1982;248(14):1724–1727. https://doi.org/10.1001/jama.248.14.1724</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Krikler D.N., Zilberg B. Activity and hepatitis. Lancet. 1966;288(7472):1046–1047. https://doi.org/10.1016/s0140-6736(66)92026-5</mixed-citation><mixed-citation xml:lang="en">Krikler D.N., Zilberg B. Activity and hepatitis. Lancet. 1966;288(7472):1046–1047. https://doi.org/10.1016/s0140-6736(66)92026-5</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts J.A. Loss of form in young athletes due to viral infection. BMJ. 1985;290(6465):357–358. https://doi.org/10.1136/bmj.290.6465.357</mixed-citation><mixed-citation xml:lang="en">Roberts J.A. Loss of form in young athletes due to viral infection. BMJ. 1985;290(6465):357–358. https://doi.org/10.1136/bmj.290.6465.357</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Roberts J.A. Viral illnesses and sports performance. Sports Med 1986;3(4):296–303. https://doi.org/10.2165/00007256-198603040-00006</mixed-citation><mixed-citation xml:lang="en">Roberts J.A. Viral illnesses and sports performance. Sports Med 1986;3(4):296–303. https://doi.org/10.2165/00007256-198603040-00006</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Sharp J.C. Viruses and the athlete. Br J Sports Med. 1989;23(1):47–48. https://doi.org/10.1136/bjsm.23.1.47</mixed-citation><mixed-citation xml:lang="en">Sharp J.C. Viruses and the athlete. Br J Sports Med. 1989;23(1):47–48. https://doi.org/10.1136/bjsm.23.1.47</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Folsom R.W., LittlefieldChabaud M.A., French D.D., Pourciau S.S., Mistric L., Horohov D.W. Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J. 2001;33(7):664–669. https://doi.org/10.2746/042516401776249417</mixed-citation><mixed-citation xml:lang="en">Folsom R.W., LittlefieldChabaud M.A., French D.D., Pourciau S.S., Mistric L., Horohov D.W. Exercise alters the immune response to equine influenza virus and increases susceptibility to infection. Equine Vet J. 2001;33(7):664–669. https://doi.org/10.2746/042516401776249417</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Parker S., Brukner P., Rosier M. Chronic fatigue syndrome and the athlete. Sports Med Train Rehab. 1996;6(4):269–278. https://doi.org/10.1080/15438629609512057</mixed-citation><mixed-citation xml:lang="en">Parker S., Brukner P., Rosier M. Chronic fatigue syndrome and the athlete. Sports Med Train Rehab. 1996;6(4):269–278. https://doi.org/10.1080/15438629609512057</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Sanchez J.L., Cooper M.J., Myers C.A., Cummings J.F., Vest K.G., Russell K.L., et al. Respiratory infections in the U.S. military: recent experience and control. Clin Microbiol Rev. 2015;28(3):743– 800. https://doi.org/10.1128/cmr.00039-14</mixed-citation><mixed-citation xml:lang="en">Sanchez J.L., Cooper M.J., Myers C.A., Cummings J.F., Vest K.G., Russell K.L., et al. Respiratory infections in the U.S. military: recent experience and control. Clin Microbiol Rev. 2015;28(3):743– 800. https://doi.org/10.1128/cmr.00039-14</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Lila M.A., Gillitt N.D. Immunometabolism: a multi–omics approach to interpreting the influence of exercise and diet on the immune system. Annu Rev Food Sci Technol. 2019;10(1):341–363. https://doi.org/10.1146/annurev-food-032818-121316</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Lila M.A., Gillitt N.D. Immunometabolism: a multi–omics approach to interpreting the influence of exercise and diet on the immune system. Annu Rev Food Sci Technol. 2019;10(1):341–363. https://doi.org/10.1146/annurev-food-032818-121316</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C. Immune response to heavy exertion. J Appl Physiol. 1997;82(5):1385–1394. https://doi.org/10.1152/jappl.1997.82.5.1385</mixed-citation><mixed-citation xml:lang="en">Nieman D.C. Immune response to heavy exertion.  J Appl Physiol. 1997;82(5):1385–1394. https://doi.org/10.1152/jappl.1997.82.5.1385</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Simpson R.J., Campbell J.P., Gleeson M., Krüger K., Nieman D.C., Pyne D.B., et al. Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev, 2020;26:8–22.</mixed-citation><mixed-citation xml:lang="en">Simpson R.J., Campbell J.P., Gleeson M., Krüger K., Nieman D.C., Pyne D.B., et al. Can exercise affect immune function to increase susceptibility to infection? Exerc Immunol Rev, 2020;26:8–22.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Groen A.J., Pugachev A., Simonson A.J., Polley K., James K., et al. Proteomics based detection of immune dysfunction in an elite adventure athlete trekking across the Antarctica. Proteomes. 2020;8(1):4. https://doi.org/10.3390/proteomes8010004</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Groen A.J., Pugachev A., Simonson A.J., Polley K., James K., et al. Proteomics based detection of immune dysfunction in an elite adventure athlete trekking across the Antarctica. Proteomes. 2020;8(1):4. https://doi.org/10.3390/proteomes8010004</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Wentz L.M. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201–217. https://doi.org/10.1016/j.jshs.2018.09.009</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Wentz L.M. The compelling link between physical activity and the body’s defense system. J Sport Health Sci. 2019;8(3):201–217. https://doi.org/10.1016/j.jshs.2018.09.009</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Раджабкадиев Р.М., Ригер Н.А., Никитюк Д.Б., Галстян А.Г., Петров А.Н., Евсюкова А.О., Ханферьян Р.А. Cопоставление уровня иммунорегуляторных цитокинов и некоторых антропометрических показателей высококвалифицированных спортсменов. Медицинская иммунология. 2018;20(1):53–60. https://doi.org/10.15789/1563-0625-2018-1-53-60</mixed-citation><mixed-citation xml:lang="en">Radzhabkadiev R.M., Riger N.A., Nikityuk D.B., Galstyan A.G., Petrov A.N., Evsyukova A.O., Khanferyan R.A. Comparison of the level of immunoregulatory cytokines and some anthropometric indicators of highly qualified athletes. Meditsinskaya immunologiya = Medical immunology. 2018;20(1):53–60.  https://doi.org/10.15789/1563-0625-2018-1-53-60 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Евстратова В.С., Никитюк Д.Б., Ригер Н.А., Федянина Н.В., Ханферьян Р.А. Оценка секреции in vitro иммунорегуляторных цитокинов дендритными клетками спортсменов-горнолыжников. Бюлл. экспер. биол. и мед., 2016;162(7):72–74.</mixed-citation><mixed-citation xml:lang="en">Evstratova V.S., Nikityuk D.B., Riger N.A., Fedyanina N.V., Khanferyan R.A. Evaluation of in vitro secretion of immunoregulatory cytokines by dendritic cells of athletes-skiers. Byulleten&amp;apos; eksperimental&amp;apos;noy biologii i meditsiny = Bull. Exp. Biol. and Med., 2016;162(7):72–74 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips M., Robinowitz M., Higgins J.R., Boran K.J., Reed T., Virmani R. Sudden cardiac death in Air Force recruits. A 20-year review. JAMA. 1986;256(19):2696–2699. https://doi.org/10.1001/jama.1986.03380190066026</mixed-citation><mixed-citation xml:lang="en">Phillips M., Robinowitz M., Higgins J.R., Boran K.J., Reed T., Virmani R. Sudden cardiac death in Air Force recruits. A 20-year review. JAMA. 1986;256(19):2696–2699. https://doi.org/10.1001/jama.1986.03380190066026</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Drory Y., Kramer M.R., Lev B. Exertional sudden death in soldiers. Med Sci Sports Exerc 1991;23(2):147–151. https://doi.org/10.1249/00005768-199102000-00001</mixed-citation><mixed-citation xml:lang="en">Drory Y., Kramer M.R., Lev B. Exertional sudden death in soldiers. Med Sci Sports Exerc 1991;23(2):147–151. https://doi.org/10.1249/00005768-199102000-00001</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Henson D.A., Austin M.D., Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987–992. https://doi.org/10.1136/bjsm.2010.077875</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Henson D.A., Austin M.D., Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987–992. https://doi.org/10.1136/bjsm.2010.077875</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Arntson B.A., Lee W., Rozeboom K., Yoon K.J., Cunnick J.E., et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004; 22 (17-18):2298–2306. https://doi.org/10.1016/j.vaccine.2003.11.023</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Arntson B.A., Lee W., Rozeboom K., Yoon K.J., Cunnick J.E., et al. Moderate exercise improves antibody response to influenza immunization in older adults. Vaccine. 2004; 22 (17-18):2298–2306. https://doi.org/10.1016/j.vaccine.2003.11.023</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Duggal N.A., Niemiro G., Harridge S.D.R., Simpson R.J., Lord J.M. Can physical activity ameliorate immunosenescence and thereby reduce age–related multi-morbidity. Nat Rev Immunol. 2019;19(9):563–572. https://doi.org/10.1038/s41577-019-0177-9</mixed-citation><mixed-citation xml:lang="en">Duggal N.A., Niemiro G., Harridge S.D.R., Simpson R.J., Lord J.M. Can physical activity ameliorate immunosenescence and thereby reduce age–related multi-morbidity. Nat Rev Immunol. 2019;19(9):563–572. https://doi.org/10.1038/s41577-019-0177-9</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Duggal N.A., Pollock R.D., Lazarus N.R., Harridge S., Lord J.M. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17(2):e12750. https://doi.org/10.1111/acel.12750</mixed-citation><mixed-citation xml:lang="en">Duggal N.A., Pollock R.D., Lazarus N.R., Harridge S., Lord J.M. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17(2):e12750. https://doi.org/10.1111/acel.12750</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Lavin K.M., Perkins R.K., Jemiolo B., Raue U., Trappe S.W., Trappe T.A. Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. J Appl Physiol. 1985;1281):87–99. https://doi.org/10.1152/japplphysiol.00495.2019</mixed-citation><mixed-citation xml:lang="en">Lavin K.M., Perkins R.K., Jemiolo B., Raue U., Trappe S.W., Trappe T.A. Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. J Appl Physiol. 1985;1281):87–99. https://doi.org/10.1152/japplphysiol.00495.2019</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Ledo A., Schub D., Ziller C., Enders M., Stenger T., Gärtner B.C. Elite athletes on regular training show more pronounced induction of vaccine-specific T-cells and antibodies after tetravalent influenza vaccination than controls. Brain Behav Immun. 2020;83:135–145. https://doi.org/10.1016/j.bbi.2019.09.024</mixed-citation><mixed-citation xml:lang="en">Ledo A., Schub D., Ziller C., Enders M., Stenger T., Gärtner B.C. Elite athletes on regular training show more pronounced induction of vaccine-specific T-cells and antibodies after tetravalent influenza vaccination than controls. Brain Behav Immun. 2020;83:135–145. https://doi.org/10.1016/j.bbi.2019.09.024</mixed-citation></citation-alternatives></ref><ref id="cit74"><label>74</label><citation-alternatives><mixed-citation xml:lang="ru">Warren K.J., Olson M.M., Thompson N.J., Cahill M.L., Wyatt T.A., Yoon K.J., et al. Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms. PLoS One. 2015;10(6):e0129713. https://doi.org/10.1371/journal.pone.0129713</mixed-citation><mixed-citation xml:lang="en">Warren K.J., Olson M.M., Thompson N.J., Cahill M.L., Wyatt T.A., Yoon K.J., et al. Exercise improves host response to influenza viral infection in obese and non-obese mice through different mechanisms. PLoS One. 2015;10(6):e0129713. https://doi.org/10.1371/journal.pone.0129713</mixed-citation></citation-alternatives></ref><ref id="cit75"><label>75</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Sim Y.J., Yu S., Yoon K.J., Loiacono C.M. Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection. J Infect Dis. 2009:200(9):1434–1442. https://doi.org/10.1086/606014</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Sim Y.J., Yu S., Yoon K.J., Loiacono C.M. Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection. J Infect Dis. 2009:200(9):1434–1442. https://doi.org/10.1086/606014</mixed-citation></citation-alternatives></ref><ref id="cit76"><label>76</label><citation-alternatives><mixed-citation xml:lang="ru">Durigon S.T., MacKenzie B., Carneiro Oliveira–Junior M., Santos-Dias A., De Angelis K., Malfitano C., et al. Aerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice. J Innate Immun. 2018;10(4):279–290. https://doi.org/10.1159/000488953</mixed-citation><mixed-citation xml:lang="en">Durigon S.T., MacKenzie B., Carneiro Oliveira–Junior M., Santos-Dias A., De Angelis K., Malfitano C., et al. Aerobic exercise protects from Pseudomonas aeruginosa-induced pneumonia in elderly mice. J Innate Immun. 2018;10(4):279–290. https://doi.org/10.1159/000488953</mixed-citation></citation-alternatives></ref><ref id="cit77"><label>77</label><citation-alternatives><mixed-citation xml:lang="ru">Shi Y., Liu T., Nieman D.C., Cui Y., Li F., Yang L., et al. Aerobic exercise attenuates acute lung injury through NET inhibition. Front Immunol. 2020;11:409. https://doi.org/10.3389/fimmu.2020.00409</mixed-citation><mixed-citation xml:lang="en">Shi Y., Liu T., Nieman D.C., Cui Y., Li F., Yang L., et al. Aerobic exercise attenuates acute lung injury through NET inhibition. Front Immunol. 2020;11:409. https://doi.org/10.3389/fimmu.2020.00409</mixed-citation></citation-alternatives></ref><ref id="cit78"><label>78</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta P., Bigley A.B., Markofski M., Laughlin M., LaVoy E.C. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018;71:81–92. https://doi.org/10.1016/j.bbi.2018.04.007</mixed-citation><mixed-citation xml:lang="en">Gupta P., Bigley A.B., Markofski M., Laughlin M., LaVoy E.C. Autologous serum collected 1 h post-exercise enhances natural killer cell cytotoxicity. Brain Behav Immun. 2018;71:81–92.  https://doi.org/10.1016/j.bbi.2018.04.007</mixed-citation></citation-alternatives></ref><ref id="cit79"><label>79</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Henson D.A., Austin M.D., Brown V.A. Immune response to a 30-minute walk. Med Sci Sports Exerc. 2005;37(1):57–62. https://doi.org/10.1249/01.mss.0000149808.38194.21</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Henson D.A., Austin M.D., Brown V.A. Immune response to a 30-minute walk. Med Sci Sports Exerc. 2005;37(1):57–62. https://doi.org/10.1249/01.mss.0000149808.38194.21</mixed-citation></citation-alternatives></ref><ref id="cit80"><label>80</label><citation-alternatives><mixed-citation xml:lang="ru">Sellami M., Gasmi M., Denham J., Hayes L.D., Stratton D., Padulo J., et al. Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Front Immunol. 2018;9:2187. https://doi.org/10.3389/fimmu.2018.02187</mixed-citation><mixed-citation xml:lang="en">Sellami M., Gasmi M., Denham J., Hayes L.D.,  Stratton D., Padulo J., et al. Effects of acute and chronic exercise on immunological parameters in the elderly aged: can physical activity counteract the effects of aging? Front Immunol. 2018;9:2187. https://doi.org/10.3389/fimmu.2018.02187</mixed-citation></citation-alternatives></ref><ref id="cit81"><label>81</label><citation-alternatives><mixed-citation xml:lang="ru">Agha N.H., Mehta S.K., Rooney B.V., Laughlin M.S., Markofski M.M., Pierson D.L., et al. Exercise as a countermeasure for latent viral reactivation during long duration space flight. FASEB J. 2020;34(2):2869–2881. https://doi.org/10.1096/fj.201902327r</mixed-citation><mixed-citation xml:lang="en">Agha N.H., Mehta S.K., Rooney B.V., Laughlin M.S., Markofski M.M., Pierson D.L., et al. Exercise as a countermeasure for latent viral reactivation during long duration space flight. FASEB J. 2020;34(2):2869–2881. https://doi.org/10.1096/fj.201902327r</mixed-citation></citation-alternatives></ref><ref id="cit82"><label>82</label><citation-alternatives><mixed-citation xml:lang="ru">Bigley A.B., Rezvani K., Chew C., Sekine T., Pistillo M., Crucian B., et al. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav Immun. 2014;39:160–171. https://doi.org/10.1016/j.bbi.2013.10.030</mixed-citation><mixed-citation xml:lang="en">Bigley A.B., Rezvani K., Chew C., Sekine T., Pistillo M., Crucian B., et al. Acute exercise preferentially redeploys NK-cells with a highly-differentiated phenotype and augments cytotoxicity against lymphoma and multiple myeloma target cells. Brain Behav Immun. 2014;39:160–171. https://doi.org/10.1016/j.bbi.2013.10.030</mixed-citation></citation-alternatives></ref><ref id="cit83"><label>83</label><citation-alternatives><mixed-citation xml:lang="ru">Simpson R.J., Bigley A.B., Agha N., Hanley P.J., Bollard C.M. Mobilizing immune cells with exercise for cancer immunotherapy. Exerc Sport Sci Rev. 2017;45(3):163–172. https://doi.org/10.1249/jes.0000000000000114</mixed-citation><mixed-citation xml:lang="en">Simpson R.J., Bigley A.B., Agha N., Hanley P.J., Bollard C.M. Mobilizing immune cells with exercise for cancer immunotherapy. Exerc Sport Sci Rev. 2017;45(3):163–172. https://doi.org/10.1249/jes.0000000000000114</mixed-citation></citation-alternatives></ref><ref id="cit84"><label>84</label><citation-alternatives><mixed-citation xml:lang="ru">Turner J.E., Spielmann G., Wadley A.J., Aldred S., Simpson R.J., Campbell J.P. Exercise-induced B cell mobilization: preliminary evidence for an influx of immature cells into the bloodstream. Physiol Behav. 2016;164:376–382. https://doi.org/10.1016/j.physbeh.2016.06.023</mixed-citation><mixed-citation xml:lang="en">Turner J.E., Spielmann G., Wadley A.J., Aldred S., Simpson R.J., Campbell J.P. Exercise-induced B cell mobilization: preliminary evidence for an influx of immature cells into the bloodstream. Physiol Behav. 2016;164:376–382. https://doi.org/10.1016/j.physbeh.2016.06.023</mixed-citation></citation-alternatives></ref><ref id="cit85"><label>85</label><citation-alternatives><mixed-citation xml:lang="ru">Campbell J.P., Riddell N.E., Burns V.E., Turner M., van Zanten J.J., Drayson M.T., et al. Acute exercise mobilizes CD8+ T lymphocytes exhibiting an effector-memory phenotype. Brain Behav Immun. 2009;23(6):767–775. https://doi.org/10.1016/j.bbi.2009.02.011</mixed-citation><mixed-citation xml:lang="en">Campbell J.P., Riddell N.E., Burns V.E., Turner M., van Zanten J.J., Drayson M.T., et al. Acute exercise mobilizes CD8+ T lymphocytes exhibiting an effector-memory phenotype. Brain Behav Immun. 2009;23(6):767–775. https://doi.org/10.1016/j.bbi.2009.02.011</mixed-citation></citation-alternatives></ref><ref id="cit86"><label>86</label><citation-alternatives><mixed-citation xml:lang="ru">Lavin K.M., Perkins R.K., Jemiolo B., Raue U., Trappe S.W., Trappe T.A. Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. J Appl Physiol. 2020;128(1):87–99. https://doi.org/10.1152/japplphysiol.00495.2019</mixed-citation><mixed-citation xml:lang="en">Lavin K.M., Perkins R.K., Jemiolo B., Raue U., Trappe S.W., Trappe T.A. Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation. J Appl Physiol. 2020;128(1):87–99. https://doi.org/10.1152/japplphysiol.00495.2019</mixed-citation></citation-alternatives></ref><ref id="cit87"><label>87</label><citation-alternatives><mixed-citation xml:lang="ru">Kohut M.L., Cooper M.M., Nickolaus M.S., Russell D.R., Cunnick J.E. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002;57(9):M557–M562. https://doi.org/10.1093/gerona/57.9.m557</mixed-citation><mixed-citation xml:lang="en">Kohut M.L., Cooper M.M., Nickolaus M.S., Russell D.R., Cunnick J.E. Exercise and psychosocial factors modulate immunity to influenza vaccine in elderly individuals. J Gerontol A Biol Sci Med Sci. 2002;57(9):M557–M562. https://doi.org/10.1093/gerona/57.9.m557</mixed-citation></citation-alternatives></ref><ref id="cit88"><label>88</label><citation-alternatives><mixed-citation xml:lang="ru">Duggal N.A., Pollock R.D., Lazarus N.R., Harridge S., Lord J.M. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17(2):e12750. https://doi.org/10.1111/acel.12750</mixed-citation><mixed-citation xml:lang="en">Duggal N.A., Pollock R.D., Lazarus N.R., Harridge S., Lord J.M. Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood. Aging Cell. 2018;17(2):e12750. https://doi.org/10.1111/acel.12750</mixed-citation></citation-alternatives></ref><ref id="cit89"><label>89</label><citation-alternatives><mixed-citation xml:lang="ru">Shanely R.A., Nieman D.C., Henson D.A., Jin F., Knab A.M., Sha W. Inflammation and oxidative stress are lower in physically fit and active adults. Scand J Med Sci Sports. 2013;23(2):215–223. https://doi.org/10.1111/j.1600-0838.2011.01373.x</mixed-citation><mixed-citation xml:lang="en">Shanely R.A., Nieman D.C., Henson D.A., Jin F., Knab A.M., Sha W. Inflammation and oxidative stress are lower in physically fit and active adults. Scand J Med Sci Sports. 2013;23(2):215–223. https://doi.org/10.1111/j.1600-0838.2011.01373.x</mixed-citation></citation-alternatives></ref><ref id="cit90"><label>90</label><citation-alternatives><mixed-citation xml:lang="ru">Wedell-Neergaard A.S., Krogh-Madsen R., Peter¬sen G.L., Hansen A.M., Pedersen B.K., Lund R., et al. Cardiorespiratory fitness and the metabolic syndrome: roles of inflammation and abdominal obesity. PLoS One. 2018;13(3):e0194991. https://doi.org/10.1371/journal.pone.0194991</mixed-citation><mixed-citation xml:lang="en">Wedell-Neergaard A.S., Krogh-Madsen R., Peter¬sen G.L., Hansen A.M., Pedersen B.K., Lund R., et al. Cardiorespiratory fitness and the metabolic syndrome: roles of inflammation and abdominal obesity. PLoS One. 2018;13(3):e0194991. https://doi.org/10.1371/journal.pone.0194991</mixed-citation></citation-alternatives></ref><ref id="cit91"><label>91</label><citation-alternatives><mixed-citation xml:lang="ru">Ригер Н.А., Евстратова В.С., Апрятин С.А., Гмошинский И.В., Ханферьян Р.А. Значение соотношения концентраций лептина и грелина как биомаркера при индуцированной диетой гиперлипидемии у самок мышей C57Black/6J. Медицинская иммунология. 2018;20(3):341–352. https://doi.org/10.15789/1563-0625-2018-3-341-352</mixed-citation><mixed-citation xml:lang="en">Riger N.A., Evstratova V.S., Apryatin S.A., Gmoshinsky I.V., Khanferyan R.A. Significance of the ratio of leptin and ghrelin concentrations as a biomarker for diet-induced hyperlipidemia in female C57Black / 6J mice. Meditsinskaya immunologiya = Medical immunology. 2018;20(3):341–352 (In Russ.). https://doi.org/10.15789/1563-0625-2018-3-341-352</mixed-citation></citation-alternatives></ref><ref id="cit92"><label>92</label><citation-alternatives><mixed-citation xml:lang="ru">Charland K.M., Buckeridge D.L., Hoen A.G., Berry J.G., Elixhauser A., Melton F., et al. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013;7(5):718–728. https://doi.org/10.1111/irv.12019</mixed-citation><mixed-citation xml:lang="en">Charland K.M., Buckeridge D.L., Hoen A.G., Berry J.G., Elixhauser A., Melton F., et al. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013;7(5):718–728. https://doi.org/10.1111/irv.12019</mixed-citation></citation-alternatives></ref><ref id="cit93"><label>93</label><citation-alternatives><mixed-citation xml:lang="ru">Wong C.M., Chan W.M., Yang L., Chan K.P., Lai H.K., Thach T.Q., et al. Effect of lifestyle factors on risk of mortality associated with influenza in elderly people. Hong Kong Med J. 2014;20(6):S16–S19.</mixed-citation><mixed-citation xml:lang="en">Wong C.M., Chan W.M., Yang L., Chan K.P., Lai H.K., Thach T.Q., et al. Effect of lifestyle factors on risk of mortality associated with influenza in elderly people. Hong Kong Med J. 2014;20(6):S16–S19.</mixed-citation></citation-alternatives></ref><ref id="cit94"><label>94</label><citation-alternatives><mixed-citation xml:lang="ru">Nieman D.C., Henson D.A., Austin M.D., Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987–992. https://doi.org/10.1136/bjsm.2010.077875</mixed-citation><mixed-citation xml:lang="en">Nieman D.C., Henson D.A., Austin M.D., Sha W. Upper respiratory tract infection is reduced in physically fit and active adults. Br J Sports Med. 2011;45(12):987–992. https://doi.org/10.1136/bjsm.2010.077875</mixed-citation></citation-alternatives></ref><ref id="cit95"><label>95</label><citation-alternatives><mixed-citation xml:lang="ru">Baik I., Curhan G.C., Rimm E.B., Bendich A., Willett W.C., Fawzi W.W. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med. 2000;160(20):3082–3088. https://doi.org/10.1001/archinte.160.20.3082</mixed-citation><mixed-citation xml:lang="en">Baik I., Curhan G.C., Rimm E.B., Bendich A., Willett W.C., Fawzi W.W. A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women. Arch Intern Med. 2000;160(20):3082–3088. https://doi.org/10.1001/archinte.160.20.3082</mixed-citation></citation-alternatives></ref><ref id="cit96"><label>96</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue Y., Koizumi A., Wada Y., Iso H., Watanabe Y., Date C., et al. Risk and protective factors related to mortality from pneumonia among middle-aged and elderly community residents: the JACC Study. J Epidemiol. 2007;17(6):194–202. https://doi.org/10.2188/jea.17.194</mixed-citation><mixed-citation xml:lang="en">Inoue Y., Koizumi A., Wada Y., Iso H., Watanabe Y., Date C., et al. Risk and protective factors related to mortality from pneumonia among middle-aged and elderly community residents: the JACC Study. J Epidemiol. 2007;17(6):194–202. https://doi.org/10.2188/jea.17.194</mixed-citation></citation-alternatives></ref><ref id="cit97"><label>97</label><citation-alternatives><mixed-citation xml:lang="ru">Wong C.M., Lai H.K., Ou C.Q., Ho S.Y., Chan K.P., Thach T.Q., et al. Is exercise protective against influenza-associated mortality? PLoS One. 2008;3(5):e2108. https://doi.org/10.1371/journal.pone.0002108</mixed-citation><mixed-citation xml:lang="en">Wong C.M., Lai H.K., Ou C.Q., Ho S.Y., Chan K.P., Thach T.Q., et al. Is exercise protective against influenza-associated mortality? PLoS One. 2008;3(5):e2108. https://doi.org/10.1371/journal.pone.0002108</mixed-citation></citation-alternatives></ref><ref id="cit98"><label>98</label><citation-alternatives><mixed-citation xml:lang="ru">Neuman M.I., Willett W.C., Curhan G.C. Physical activity and the risk of community-acquired pneumonia in US women. Am J Med. 2010;123(3):281.e7–281.e11. https://doi.org/10.1016/j.amjmed.2009.07.028</mixed-citation><mixed-citation xml:lang="en">Neuman M.I., Willett W.C., Curhan G.C. Physical activity and the risk of community-acquired pneumonia in US women. Am J Med. 2010;123(3):281.e7–281.e11. https://doi.org/10.1016/j.amjmed.2009.07.028</mixed-citation></citation-alternatives></ref><ref id="cit99"><label>99</label><citation-alternatives><mixed-citation xml:lang="ru">Williams P.T. Dose-response relationship between exercise and respiratory disease mortality. Med Sci Sports Exerc. 2014;46(4):711–717. https://doi.org/10.1249/mss.0000000000000142</mixed-citation><mixed-citation xml:lang="en">Williams P.T. Dose-response relationship between exercise and respiratory disease mortality. Med Sci Sports Exerc. 2014;46(4):711–717. https://doi.org/10.1249/mss.0000000000000142</mixed-citation></citation-alternatives></ref><ref id="cit100"><label>100</label><citation-alternatives><mixed-citation xml:lang="ru">Wu S., Ma C., Yang Z., Yang P., Chu Y., Zhang H., et al. Hygiene behaviors associated with influenza-like illness among adults in Beijing, China: a large, population-based survey. PLoS One. 2016;11(2):e0148448. https://doi.org/10.1371/journal.pone.0148448</mixed-citation><mixed-citation xml:lang="en">Wu S., Ma C., Yang Z., Yang P., Chu Y., Zhang H., et al. Hygiene behaviors associated with influenza-like illness among adults in Beijing, China: a large, population-based survey. PLoS One. 2016;11(2):e0148448. https://doi.org/10.1371/journal.pone.0148448</mixed-citation></citation-alternatives></ref><ref id="cit101"><label>101</label><citation-alternatives><mixed-citation xml:lang="ru">Ukawa S., Zhao W., Yatsuya H., Yamagishi K., Tanabe N., Iso H., Tamakoshi A. Associations of daily walking time with pneumonia mortality among elderly individuals with or without a medical history of myocardial infarction or stroke: findings from the Japan Collaborative Cohort Study. J Epidemiol. 2019;29(6):233–237. https://doi.org/10.2188/jea.je20170341</mixed-citation><mixed-citation xml:lang="en">Ukawa S., Zhao W., Yatsuya H., Yamagishi K., Tanabe N., Iso H., Tamakoshi A. Associations of daily walking time with pneumonia mortality among elderly individuals with or without a medical history of myocardial infarction or stroke: findings from the Japan Collaborative Cohort Study. J Epidemiol. 2019;29(6):233–237. https://doi.org/10.2188/jea.je20170341</mixed-citation></citation-alternatives></ref><ref id="cit102"><label>102</label><citation-alternatives><mixed-citation xml:lang="ru">Hamer M., O’Donovan G., Stamatakis E. Lifestyle risk factors, obesity and infectious disease mortality in the general population: linkage study of 97,844 adults from England and Scotland. Prev Med. 2019;123:65–70. https://doi.org/10.1016/j.ypmed.2019.03.002</mixed-citation><mixed-citation xml:lang="en">Hamer M., O’Donovan G., Stamatakis E. Lifestyle risk factors, obesity and infectious disease mortality in the general population: linkage study of 97,844 adults from England and Scotland. Prev Med. 2019;123:65–70. https://doi.org/10.1016/j.ypmed.2019.03.002</mixed-citation></citation-alternatives></ref><ref id="cit103"><label>103</label><citation-alternatives><mixed-citation xml:lang="ru">Charland K.M., Buckeridge D.L., Hoen A.G., Berry J.G., Elixhauser A., Melton F., et al. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013;7(5):718–728. https://doi.org/10.1111/irv.12019</mixed-citation><mixed-citation xml:lang="en">Charland K.M., Buckeridge D.L., Hoen A.G., Berry J.G., Elixhauser A., Melton F., et al. Relationship between community prevalence of obesity and associated behavioral factors and community rates of influenza-related hospitalizations in the United States. Influenza Other Respir Viruses. 2013;7(5):718–728. https://doi.org/10.1111/irv.12019</mixed-citation></citation-alternatives></ref><ref id="cit104"><label>104</label><citation-alternatives><mixed-citation xml:lang="ru">Lowder T., Padgett D.A., Woods J.A. Moderate exercise protects micefrom death due to influenza virus. Brain Behav Immun. 2005; 19(5):377–380. https://doi.org/10.1016/j.bbi.2005.04.002</mixed-citation><mixed-citation xml:lang="en">Lowder T., Padgett D.A., Woods J.A. Moderate exercise protects micefrom death due to influenza virus. Brain Behav Immun. 2005; 19(5):377–380. https://doi.org/10.1016/j.bbi.2005.04.002</mixed-citation></citation-alternatives></ref><ref id="cit105"><label>105</label><citation-alternatives><mixed-citation xml:lang="ru">Paulsen J., Askim Å., Mohus R.M., Mehl A., Dewan A., Solligård E., et al. Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15–year follow-up of 64 027 individuals in the HUNT Study. Int J Epidemiol. 2017;46(5):1573–1581. https://doi.org/10.1093/ije/dyx091</mixed-citation><mixed-citation xml:lang="en">Paulsen J., Askim Å., Mohus R.M., Mehl A., Dewan A., Solligård E., et al. Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15–year follow-up of 64 027 individuals in the HUNT Study. Int J Epidemiol. 2017;46(5):1573–1581. https://doi.org/10.1093/ije/dyx091</mixed-citation></citation-alternatives></ref><ref id="cit106"><label>106</label><citation-alternatives><mixed-citation xml:lang="ru">Powell K.E., King A.C., Buchner D.M., Campbell W.W., DiPietro L., Erickson K.I., et al. The scientific foundation for the physical activity guidelines for Americans, 2nd edition. J Phys Act Health. 2019;16(1):1–11. https://doi.org/10.1123/ jpah.2018-0618</mixed-citation><mixed-citation xml:lang="en">Powell K.E., King A.C., Buchner D.M., Campbell W.W., DiPietro L., Erickson K.I., et al. The scientific foundation for the physical activity guidelines for Americans, 2nd edition. J Phys Act Health. 2019;16(1):1–11. https://doi.org/10.1123/ jpah.2018-0618</mixed-citation></citation-alternatives></ref><ref id="cit107"><label>107</label><citation-alternatives><mixed-citation xml:lang="ru">Jordan R.E., Adab P., Cheng K.K. Covid-19: risk factors for severe disease and death. BMJ. 2020;368:m1198. https://doi.org/10.1136/bmj.m1198</mixed-citation><mixed-citation xml:lang="en">Jordan R.E., Adab P., Cheng K.K. Covid-19: risk factors for severe disease and death. BMJ. 2020;368:m1198. https://doi.org/10.1136/bmj.m1198</mixed-citation></citation-alternatives></ref><ref id="cit108"><label>108</label><citation-alternatives><mixed-citation xml:lang="ru">Смирнов В.С., Тотолян А.А. Врожденный иммунитет при коронавирусной инфекции. Инфекция и иммунитет. 2020;10(2):259–268. https://doi.org/10.15789/2220-7619-III-1440</mixed-citation><mixed-citation xml:lang="en">Smirnov V.S., Totolyan A.A. Congenital immunity in coronavirus infection. Infektsiya i immunitet = Infection and immunity. 2020;10(2):259-268 (In Russ.). https://doi.org/10.15789/2220-7619-III-1440</mixed-citation></citation-alternatives></ref><ref id="cit109"><label>109</label><citation-alternatives><mixed-citation xml:lang="ru">Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/s0140-6736(20)30183-5</mixed-citation><mixed-citation xml:lang="en">Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. https://doi.org/10.1016/s0140-6736(20)30183-5</mixed-citation></citation-alternatives></ref><ref id="cit110"><label>110</label><citation-alternatives><mixed-citation xml:lang="ru">Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319–1325. https://doi.org/10.1016/s0140-6736(03)13077-2</mixed-citation><mixed-citation xml:lang="en">Peiris J.S., Lai S.T., Poon L.L., Guan Y., Yam L.Y., Lim W., et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319–1325. https://doi.org/10.1016/s0140-6736(03)13077-2</mixed-citation></citation-alternatives></ref><ref id="cit111"><label>111</label><citation-alternatives><mixed-citation xml:lang="ru">Chien J.Y., Hsueh P.R., Cheng W.C., Yu C.J., Yang P.C. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology. 2006;11(6):715–722. https://doi.org/10.1111/j.1440-1843.2006.00942.x</mixed-citation><mixed-citation xml:lang="en">Chien J.Y., Hsueh P.R., Cheng W.C., Yu C.J., Yang P.C. Temporal changes in cytokine/chemokine profiles and pulmonary involvement in severe acute respiratory syndrome. Respirology. 2006;11(6):715–722. https://doi.org/10.1111/j.1440-1843.2006.00942.x</mixed-citation></citation-alternatives></ref><ref id="cit112"><label>112</label><citation-alternatives><mixed-citation xml:lang="ru">Wong C.K., Lam C.W., Wu A.K., Ip W.K., Lee N.L., Chan I.H., et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004;136(1):95–103. https://doi.org/10.1111/j.1365-2249.2004.02415.x</mixed-citation><mixed-citation xml:lang="en">Wong C.K., Lam C.W., Wu A.K., Ip W.K., Lee N.L., Chan I.H., et al. Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol. 2004;136(1):95–103. https://doi.org/10.1111/j.1365-2249.2004.02415.x</mixed-citation></citation-alternatives></ref><ref id="cit113"><label>113</label><citation-alternatives><mixed-citation xml:lang="ru">Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans. 2017;45(4):905–911. https://doi.org/10.1042/bst20160466</mixed-citation><mixed-citation xml:lang="en">Hojman P. Exercise protects from cancer through regulation of immune function and inflammation. Biochem Soc Trans. 2017;45(4):905–911. https://doi.org/10.1042/bst20160466</mixed-citation></citation-alternatives></ref><ref id="cit114"><label>114</label><citation-alternatives><mixed-citation xml:lang="ru">Grande A., Keogh J., Silva V., Scott A.M. Exercise versus no exercisefor the occurrence, severity, and duration of acute respiratory infections. Cochrane Database Syst Rev. 2020;4(4):CD010596. https://doi.org/10.1002/14651858.cd010596.pub3</mixed-citation><mixed-citation xml:lang="en">Grande A., Keogh J., Silva V., Scott A.M. Exercise versus no exercisefor the occurrence, severity, and duration of acute respiratory infections. Cochrane Database Syst Rev. 2020;4(4):CD010596. https://doi.org/10.1002/14651858.cd010596.pub3</mixed-citation></citation-alternatives></ref><ref id="cit115"><label>115</label><citation-alternatives><mixed-citation xml:lang="ru">Pascoe A.R., Fiatarone Singh M.A., Edwards K.M. The effects of exercise on vaccination responses: a review of chronic and acute exercise interventions in humans. Brain Behav Immun. 2014;39:33–41. https://doi.org/10.1016/j.bbi.2013.10.003</mixed-citation><mixed-citation xml:lang="en">Pascoe A.R., Fiatarone Singh M.A., Edwards K.M. The effects of exercise on vaccination responses: a review of chronic and acute exercise interventions in humans. Brain Behav Immun. 2014;39:33–41. https://doi.org/10.1016/j.bbi.2013.10.003</mixed-citation></citation-alternatives></ref><ref id="cit116"><label>116</label><citation-alternatives><mixed-citation xml:lang="ru">Sallis J.F., Adlakha D., Oyeyemi A., Salvo D. An international physical activity and public health research agenda to inform coronavirus disease-19 policies and practices. J Sport Health Sci. 2020;9(4):328–334. https://doi.org/10.1016/j.jshs.2020.05.005</mixed-citation><mixed-citation xml:lang="en">Sallis J.F., Adlakha D., Oyeyemi A., Salvo D. An international physical activity and public health research agenda to inform coronavirus disease-19 policies and practices. J Sport Health Sci. 2020;9(4):328–334. https://doi.org/10.1016/j.jshs.2020.05.005</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
