<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">smjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Спортивная медицина: наука и практика</journal-title><trans-title-group xml:lang="en"><trans-title>Sports medicine: research and practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2524</issn><issn pub-type="epub">2587-9014</issn><publisher><publisher-name>NEICON</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47529/2223-2524.2021.4.3</article-id><article-id custom-type="elpub" pub-id-type="custom">smjournal-343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВРАЧЕБНЫЙ КОНТРОЛЬ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MEDICAL CONTROL</subject></subj-group></article-categories><title-group><article-title>Приобретенное удлинение интервала QT у спортсменов</article-title><trans-title-group xml:lang="en"><trans-title>Acquired long QT interval in athletes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юнисова</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Yunisova</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юнисова Алина Саидовна, аспирант кафедры спортивной медицины</p><p>105122, Россия, Москва, Сиреневый бульвар, 4</p></bio><bio xml:lang="en"><p>Alina S. Yunisova — M.D., Graduate student of the Department of Sports Medicine</p><p>4, Sirenevyi blvd., Moscow, 105122, Russia</p></bio><email xlink:type="simple">yunisova.alina@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смоленский</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smolensky</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смоленский Андрей Вадимович, д.м.н., профессор, заведующий кафедрой спортивной медицины</p><p>105122, Россия, Москва, Сиреневый бульвар, 4</p></bio><bio xml:lang="en"><p>Andrey V. Smolensky — M.D., D.Sc. (Medicine), Head of the Department of Sports Medicine</p><p>4, Sirenevyi blvd., Moscow, 105122 Russia</p></bio><email xlink:type="simple">smolensky52@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский государственный университет физической культуры, спорта, молодежи и туризма»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian State University of Physical Culture, Sports, Youth and Tourism</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>05</month><year>2022</year></pub-date><volume>11</volume><issue>4</issue><fpage>17</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юнисова А.С., Смоленский А.В., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Юнисова А.С., Смоленский А.В.</copyright-holder><copyright-holder xml:lang="en">Yunisova A.S., Smolensky A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.smjournal.ru/jour/article/view/343">https://www.smjournal.ru/jour/article/view/343</self-uri><abstract><p>Синдром удлиненного синдрома QT (LQTS) — часто встречаемое нарушение состояния, приводящее к драматичным для пациентов исходам, главным из которых является внезапная сердечная смерть. В данном обзоре представлены подробные данные о диагностике, распространенности, классификации, этиологии. Многообразие причин, приводящих к LQTS, создает сложности в дифференциальной диагностике этого состояния, и в итоге LQTS часто остается за пределами внимания врачей, осуществляющих контроль состояния здоровья спортсменов. Особое внимание уделено приобретенным формам LQTS, в частности лекарственно­индуцированной форме. Изложены результаты исследований, направленных на изучение распространенности LQTS и влияние лекарственных препаратов на интервал QT. Подробно рассмотрено влияние на интервал QT нестероидных противовоспалительных средств, поскольку они часто используются спортсменами. Цель данного обзора — расширить понимание этиологии LQTS и обосновать необходимость тщательного ЭКГ­скрининга и фармакологического контроля у спортсменов.</p></abstract><trans-abstract xml:lang="en"><p>Long QT syndrome (LQTS) is a common disorder that leads to dramatic patient outcomes, chief among which is sudden cardiac death. This review provides detailed data on the diagnosis, prevalence, classification, etiology. The variety of causes leading to LQTS creates difficulties in the differential diagnosis of this condition and, as a result, LQTS often remains outside the attention of physicians who monitor the health of athletes. Particular attention is paid to the acquired forms of LQTS, particularly, the drug-induced form. The results of studies aimed at studying the prevalence of LQTS and the effect of drugs on the QT interval are presented. The influence of non-steroidal anti-inflammatory drugs on the QT interval is discussed in detail because they are often used by athletes. The purpose of this review is to expand understanding of the etiology of LQTS and justify the need for careful ECG screening and pharmacological monitoring in athletes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>интервал QT</kwd><kwd>внезапная сердечная смерть</kwd><kwd>лекарственно­индуцированный LQTS</kwd><kwd>спортсмены</kwd></kwd-group><kwd-group xml:lang="en"><kwd>QT interval</kwd><kwd>sudden cardiac death</kwd><kwd>drug-induced LQTS</kwd><kwd>athletes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ackerman M.J., Priori S.G., Willems S., Berul C., Brugada R., Calkins H., et al. HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies: Tis document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace. 2011;13(8):1077–1109. https://doi.org/10.1093/europace/eur245</mixed-citation><mixed-citation xml:lang="en">Ackerman M.J., Priori S.G., Willems S., Berul C., Brugada R., Calkins H., et al. HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace. 2011;13(8):1077–1109. https://doi.org/10.1093/ europace/eur245</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ackerman M.J. Long QT syndrome and sports participation: oil and water or an acceptable and manageable combination? JACC Clin. Electrophysiol. 2015;1(1–2):71–73. https://doi.org/10.1016/j.jacep.2015.03.009</mixed-citation><mixed-citation xml:lang="en">Ackerman M.J. Long QT syndrome and sports participation: oil and water or an acceptable and manageable combination? JACC Clin. Electrophysiol. 2015;1(1–2):71–73. https://doi.org/10.1016/j.jacep.2015.03.009</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Adler A., vander Werf C., Postema P.G., Rosso R., Bhuiyan Z.A., Kalman J.M., et al. Tephenomenon of ‘QT stunning’: Te abnormal QT prolongation provoked by standing persists even as the heart rate returns to normal in patients with long QT syndrome. Heart Rhythm. 2012;9(6):901–908. https://doi.org/10.1016/j.hrthm.2012.01.026</mixed-citation><mixed-citation xml:lang="en">Adler A., vander Werf C., Postema P.G., Rosso R., Bhuiyan Z.A., Kalman J.M., et al. Thephenomenon of ‘QT stunning’: The abnormal QT prolongation provoked by standing persists even as the heart rate returns to normal in patients with long QT syndrome. Heart Rhythm. 2012;9(6):901–908. https://doi.org/10.1016/j.hrthm.2012.01.026</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bazett H.C. An analysis of time­relations of electrocardiograms. Heart. 1920;7:353–370.</mixed-citation><mixed-citation xml:lang="en">Bazett H.C. An analysis of time-relations of electrocardiograms. Heart. 1920;7:353–370.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Border W.L., Benson D.W. Sudden infant death syndrome and long QT syndrome: the zealots versus the naysayers. Heart Rhythm. 2007;4(2):167–169. https://doi.org/10.1016/j.hrthm.2006.12.019</mixed-citation><mixed-citation xml:lang="en">Border W.L., Benson D.W. Sudden infant death syndrome and long QT syndrome: the zealots versus the naysayers. Heart Rhythm. 2007;4(2):167–169. https://doi.org/10.1016/j.hrthm.2006.12.019</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Klivinyi C., Bornemann-Cimenti H. Pain medication and long QT syndrome. Korean J. Pain. 2018;31(1):3–9. https://doi.org/10.3344/kjp.2018.31.1.3</mixed-citation><mixed-citation xml:lang="en">Klivinyi C., Bornemann-Cimenti H. Pain medication and long QT syndrome. Korean J. Pain. 2018;31(1):3–9. https://doi.org/10.3344/kjp.2018.31.1.3</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Corrado D., Basso C., Pavei A., Michieli. P., Schiavon M., Tiene G. Trends in sudden cardiovascular death in young competitive athletes afer implementation of a preparticipation screening program. JAMA. 2006; 296(13):1593–1601. https://doi.org/10.1001/jama.296.13.1593</mixed-citation><mixed-citation xml:lang="en">Corrado D., Basso C., Pavei A., Michieli P., Schiavon M., Thiene G. Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. JAMA. 2006; 296(13):1593–1601. https://doi.org/10.1001/jama.296.13.1593</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Corrado D., Pelliccia A., Bjornstad H.H., Vanhees L., Biffi A., Borjesson M., et al. Cardiovascular pre­participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Eur. Heart J. 2005;26(5): 516–524. https://doi.org/10.1093/eurheartj/ehi108</mixed-citation><mixed-citation xml:lang="en">Corrado D., Pelliccia A., Bjornstad H.H., Vanhees L., Biffi A., Borjesson M., et al. Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Eur. Heart J. 2005;26(5): 516–524. https://doi.org/10.1093/eurheartj/ehi108</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Corrado D., Basso C., Schiavon M., Tiene G. Screening for hypertrophic cardiomyopathy in young athletes. N. Eng. J. Med. 1998;339(6):364–369. https://doi.org/10.1056/NEJM199808063390602</mixed-citation><mixed-citation xml:lang="en">Corrado D., Basso C., Schiavon M., Thiene G. Screening for hypertrophic cardiomyopathy in young athletes. N. Eng. J. Med. 1998;339(6):364–369. https://doi.org/10.1056/NEJM199808063390602</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pelliccia A., Sharma S., Gati S., Bäck M., Börjesson M., Caselli S., et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur. Heart J. 2021;42(1):17–96. https://doi.org/10.1093/eurheartj/ehaa605</mixed-citation><mixed-citation xml:lang="en">Pelliccia A., Sharma S., Gati S., Bäck M., Börjesson M., Caselli S., et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur. Heart J. 2021;42(1):17–96. https://doi.org/10.1093/eurheartj/ehaa605</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Digby G.C., Perez Riera A.R., Barbosa Barros R., Simpson C.S., Redfearn D.P., Methot M., et al. Acquired Long QT Interval: A Case Series of Multifactorial QT Prolongation. Clin. Cardiol. 2011;34(9):577–582. https://doi.org/10.1002/clc.20945</mixed-citation><mixed-citation xml:lang="en">Digby G.C., Perez Riera A.R., Barbosa Barros R., Simpson C.S., Redfearn D.P., Methot M., et al. Acquired Long QT Interval: A Case Series of Multifactorial QT Prolongation. Clin. Cardiol. 2011;34(9):577–582. https://doi.org/10.1002/clc.20945</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mantovani G. Pseudohypoparathyroidism: Diagnosis and Treatment. J. Clin. Endocrinol. Metab. 2011;96(10):3020–3030. https://doi.org/10.1210/jc.2011­1048</mixed-citation><mixed-citation xml:lang="en">Mantovani G. Pseudohypoparathyroidism: Diagnosis and Treatment. J. Clin. Endocrinol. Metab. 2011;96(10):3020–3030. https://doi.org/10.1210/jc.2011-1048</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer T., Ruppert V., Karatolios K., Maisch B. Hereditary long QT syndrome due to autoimmune hypoparathyroidism in autoimmune polyendocrinopathy­candidiasis­ectodermal dystrophy syndrome. J. Electrocardiol. 2007;40(6):504–509. https://doi.org/10.1016/j.jelectrocard.2006.12.013</mixed-citation><mixed-citation xml:lang="en">Meyer T., Ruppert V., Karatolios K., Maisch B. Hereditary long QT syndrome due to autoimmune hypoparathyroidism in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome. J. Electrocardiol. 2007;40(6):504–509. https://doi.org/10.1016/j.jelectrocard.2006.12.013</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Michels G., Kochanek M., Pfster R. Life­threatening cardiac arrhythmias due to drug­induced QT prolongation. Med. Klin. Intensivmed. Notfmed. 2016;111(4):302–309. https://doi.org/10.1007/s00063­015­0071­6</mixed-citation><mixed-citation xml:lang="en">Michels G., Kochanek M., Pfister R. Life-threatening cardiac arrhythmias due to drug-induced QT prolongation. Med. Klin. Intensivmed. Notfmed. 2016;111(4):302–309. https://doi.org/10.1007/s00063-015-0071-6</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Mitchell J.H., Haskell W.L., Raven P.B. Classifcation of sports. J. Am. Coll Cardiol. 1994; 24(4):864–866. https://doi.org/10.1016/0735­1097(94)90841­9</mixed-citation><mixed-citation xml:lang="en">Mitchell J.H., Haskell W.L., Raven P.B. Classification of sports. J. Am. Coll Cardiol. 1994;24(4):864–866. https://doi.org/10.1016/0735-1097(94)90841-9</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Molokhia M., Pathak A., Lapeyre-Mestre M., Caturla L., Montastruc J L., L’Association Française des Centres Régionaux de Pharmacovigilance (CRPV), ase ascertainment and estimated incidence of drug­induced long­QT syndrome: Study in Southwest France. Br. J. Clin Pharmacol. 2008;66(3):386–395. https://doi.org/10.1111/j.1365­2125.2008.03229.x</mixed-citation><mixed-citation xml:lang="en">Molokhia M., Pathak A., Lapeyre-Mestre M., Caturla L., Montastruc J. L. L’Association Française des Centres Régionaux de Pharmacovigilance (CRPV), McKeigue P. Case ascertainment and estimated incidence of drug-induced long-QT syndrome: Study in Southwest France. Br. J. Clin Pharmacol. 2008;66(3):386–395. https://doi.org/10.1111/j.1365-2125.2008.03229.x</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Moss A.J. Long QT syndrome. JAMA. 2003;289(16):2041–2044. https://doi.org/10.1001/jama.289.16.2041</mixed-citation><mixed-citation xml:lang="en">Moss A.J. Long QT syndrome. JAMA. 2003;289(16):2041–2044. https://doi.org/10.1001/jama.289.16.2041</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Moss A.J., Schwartz P.J., Crampton R.S., Tzivoni D., Locati E.H., MacCluer J., et al. Te long QT syndrome. Prospective longitudinal study of 328 families. Circulation. 1991;84(3):1136–1144. https://doi.org/10.1161/01.cir.84.3.1136</mixed-citation><mixed-citation xml:lang="en">Moss A.J., Schwartz P.J., Crampton R.S., Tzivoni D., Locati E.H., MacCluer J., et al. The long QT syndrome. Prospective longitudinal study of 328 families. Circulation. 1991;84(3):1136–1144. https://doi.org/10.1161/01.cir.84.3.1136</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Napolitano C., Priori S.G., Schwartz P.J., Bloise R., Ronchetti E., Nastoli J., et al. Genetic testing in the long QT syndrome: development and validation of an efcient approach to genotyping in clinical practice. JAMA. 2005;294(23):2975–2980. https://doi.org/10.1001/jama.294.23.2975</mixed-citation><mixed-citation xml:lang="en">Napolitano C., Priori S.G., Schwartz P.J., Bloise R., Ronchetti E., Nastoli J., et al. Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA. 2005;294(23):2975–2980. https://doi.org/10.1001/jama.294.23.2975</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Newman D.B., Fidahussein S.S., Kashiwagi D.T., Kennel K.A., Kashani K.B., Zhen Wang, et al. Reversible cardiac dysfunction asso­ciated with hypocalcemia: a systematic review and metaanalysis of individual patient data. Heart Fail. Rev. 2014;19(2):199–205. https://doi.org/10.1007/s10741­013­9371­1</mixed-citation><mixed-citation xml:lang="en">Newman D.B., Fidahussein S.S., Kashiwagi D.T., Kennel K.A., Kashani K.B., Zhen Wang, et al. Reversible cardiac dysfunction asso-ciated with hypocalcemia: a systematic review and meta-analysis of individual patient data. Heart Fail. Rev. 2014;19(2):199–205. https://doi.org/10.1007/s10741-013-9371-1</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Pathak A., Boveda S., Defaye P., Mansourati J., Mallaret M., Tebault L., et al. Celecoxib­associated torsade de pointes. Ann Pharmacother. 2002;36(7–8):1290–1291. https://doi.org/10.1345/aph.1A429</mixed-citation><mixed-citation xml:lang="en">Pathak A., Boveda S., Defaye P., Mansourati J., Mallaret M., Thebault L., et al. Celecoxib-associated torsade de pointes. Ann Pharmacother. 2002;36(7–8):1290–1291. https://doi.org/10.1345/aph.1A429</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Pelliccia A., Fagard R., Bjørnstad H.H., Anastassakis A., Arbustini E., Assanelli D., et al. Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur. Heart J. 2005;26(14):1422–1445. https://doi.org/10.1093/eurheartj/ehi325</mixed-citation><mixed-citation xml:lang="en">Pelliccia A., Fagard R., Bjørnstad H.H., Anastassakis A., Arbustini E., Assanelli D., et al. Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur. Heart J. 2005;26(14):1422–1445. https://doi.org/10.1093/eurheartj/ehi325</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Priori S.G., Blomström-Lundqvist C., Mazzanti A., Blom N., Borggrefe M., Camm J., et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur. Heart J. 2015;36(41):2793–2867. https://doi.org/10.1093/eurheartj/ehv316</mixed-citation><mixed-citation xml:lang="en">Priori S.G., Blomström-Lundqvist C., Mazzanti A., Blom N., Borggrefe M., Camm J., et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur. Heart J. 2015;36(41):2793–2867. https://doi.org/10.1093/eurheartj/ehv316</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Priori S.G., Schwartz P.J., Napolitano C., Bloise R., Ronchetti E., Grillo M., et al. Risk Stratifcation in the Long­QT Syndrome. N. Engl. J. Med. 2003;348(19):1866–1874. https://doi.org/10.1056/nejmoa022147</mixed-citation><mixed-citation xml:lang="en">Priori S.G., Schwartz P.J., Napolitano C., Bloise R., Ronchetti E., Grillo M., et al. Risk Stratification in the Long-QT Syndrome. N. Engl. J. Med. 2003;348(19):1866–1874. https://doi.org/10.1056/nejmoa022147</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Priori S.G., Wilde A.A., Horie M., Cho Y., Behr E.R., Berul C., et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):e85–e108. https://doi.org/10.1016/j.hrthm.2013.07.021</mixed-citation><mixed-citation xml:lang="en">Priori S.G., Wilde A.A., Horie M., Cho Y., Behr E.R., Berul C., et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):e85–e108. https://doi.org/10.1016/j.hrthm.2013.07.021</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Kim J.A., Chelu M.G. Inherited Arrhythmia Syndromes. Tex Heart Inst J. 2021 Sep 1;48(4):e207482. https://doi.org/10.14503/THIJ­20­7482.</mixed-citation><mixed-citation xml:lang="en">Kim J.A., Chelu M.G. Inherited Arrhythmia Syndromes. Tex Heart Inst J. 2021 Sep 1;48(4):e207482. https://doi.org/10.14503/THIJ-20-7482.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Nakano Y., Shimizu W. Genetics of long­QT syndrome. J. Hum. Genet. 2016;61(1):51–55. https://doi.org/10.1038/jhg.2015.74</mixed-citation><mixed-citation xml:lang="en">Nakano Y., Shimizu W. Genetics of long-QT syndrome. J. Hum. Genet. 2016;61(1):51–55. https://doi.org/10.1038/jhg.2015.74</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Rajab A., Straub V., McCann L.J., Seelow D., Varon R., Barresi R., et al. Fatal cardiac arrhythmia and long­QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF­CAVIN mutations. PLoS Genet. 2010;6(3):e1000874. https://doi.org/10.1371/journal.pgen.1000874</mixed-citation><mixed-citation xml:lang="en">Rajab A., Straub V., McCann L.J., Seelow D., Varon R., Barresi R., et al. Fatal cardiac arrhythmia and long-QT syndrome in a new form of congenital generalized lipodystrophy with muscle rippling (CGL4) due to PTRF-CAVIN mutations. PLoS Genet. 2010;6(3):e1000874. https://doi.org/10.1371/journal.pgen.1000874</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Roden D.M. Predicting drug­induced QT prolongation and torsades de pointes. J. Physiol. 2016;594(9):2459–68. https://doi.org/10.1113/JP270526</mixed-citation><mixed-citation xml:lang="en">Roden D.M. Predicting drug-induced QT prolongation and torsades de pointes. J. Physiol. 2016;594(9):2459–68. https://doi.org/10.1113/JP270526</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Basavarajaiah S., Wilson M., Whyte G., Shah A., Behr E., Sharma S. Prevalence and signifcance of an isolated long QT interval in elite athletes. Eur. Heart J. 2007;28(23):2944–2949. https://doi.org/10.1093/eurheartj/ehm404</mixed-citation><mixed-citation xml:lang="en">Basavarajaiah S., Wilson M., Whyte G., Shah A., Behr E., Sharma S. Prevalence and significance of an isolated long QT interval in elite athletes. Eur. Heart J. 2007;28(23):2944–2949. https://doi.org/10.1093/eurheartj/ehm404</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz P.J., Woosley R.L. Predicting the Unpredictable: Drug­Induced QT Prolongation and Torsades de Pointes. J. Am. Coll. Cardiol. 2016;67(13):1639–1650. https://doi.org/10.1016/j.jacc.2015.12.063</mixed-citation><mixed-citation xml:lang="en">Schwartz P.J., Woosley R.L. Predicting the Unpredictable: Drug-Induced QT Prolongation and Torsades de Pointes. J. Am. Coll. Cardiol. 2016;67(13):1639–1650. https://doi.org/10.1016/j.jacc.2015.12.063</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz P.J., Moss A.J., Vincent G.M., Crampton R.S. Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993;88(2):782–784. https://doi.org/10.1161/01.cir.88.2.782</mixed-citation><mixed-citation xml:lang="en">Schwartz P.J., Moss A.J., Vincent G.M., Crampton R.S. Diagnostic criteria for the long QT syndrome. An update. Circulation. 1993;88(2):782–784. https://doi.org/10.1161/01.cir.88.2.782</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz P.J.,Crotti L.QTc behavior during exercise and genetic testing for the long­QT syndrome. Circulation. 2011;124(20):2181–2184. https://doi.org/10.1161/CIRCULATIONAHA.111.062182</mixed-citation><mixed-citation xml:lang="en">Schwartz P.J., Crotti L. QTc behavior during exercise and genetic testing for the long-QT syndrome. Circulation. 2011;124(20):2181–2184. https://doi.org/10.1161/CIRCULATIONAHA.111.062182</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma S., Whyte G., Elliott P., Padula M., Kaushal R., Mahon N., McKenna W.J. Electrocardiographic changes in 1000 highly trained junior elite athletes. Br. J. Sports Med. 1999;33(5):319–324. https://doi.org/10.1136/bjsm.33.5.319</mixed-citation><mixed-citation xml:lang="en">Sharma S., Whyte G., Elliott P., Padula M., Kaushal R., Mahon N., McKenna W.J. Electrocardiographic changes in 1000 highly trained junior elite athletes. Br. J. Sports Med. 1999;33(5):319–324. https://doi.org/10.1136/bjsm.33.5.319</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Straus M., Sturkenboom M.C., Bleumink G.S., Dieleman J.P., van der Lei J., de Graeﬀ P.A., et al. Non­cardiac QTcprolonging drugs and the risk of sudden cardiac death. Eur. Heart J. 2005;26(19):2007–2012. https://doi.org/10.1093/eurheartj/ehi312</mixed-citation><mixed-citation xml:lang="en">Straus M., Sturkenboom M.C., Bleumink G.S., Dieleman J.P., van der Lei J., de Graeff P.A., et al. Non-cardiac QTcprolonging drugs and the risk of sudden cardiac death. Eur. Heart J. 2005;26(19):2007–2012. https://doi.org/10.1093/eurheartj/ehi312</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Maury P., Delasnerie H., Beneyto M., Rollin A. Autonomic cardiac innervation: impact on the evolution of arrhythmias in inherited cardiac arrhythmia syndromes. Herzschrittmacherther Elektrophysiol. 2021 Sep;32(3):308–314. English. https://doi.org/10.1007/s00399­021­00774­3 Epub 2021 Jun 29.</mixed-citation><mixed-citation xml:lang="en">Maury P., Delasnerie H., Beneyto M., Rollin A. Autonomic cardiac innervation: impact on the evolution of arrhythmias in inherited cardiac arrhythmia syndromes. Herzschrittmacherther Elektrophysiol. 2021 Sep;32(3):308–314. English. https://doi.org/10.1007/s00399-021-00774-3 Epub 2021 Jun 29.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Turan S. Current nomenclature of pseudohypoparathyroidism: inactivating parathyroid hormone / parathyroid hormonerelated protein signaling disorder. J. Clin. Res. Pediatr. Endocrinol. 2017;9(2):58–68. https://doi.org/10.4274/jcrpe.2017.s006</mixed-citation><mixed-citation xml:lang="en">Turan S. Current nomenclature of pseudohypoparathyroidism: inactivating parathyroid hormone / parathyroid hormonerelated protein signaling disorder. J. Clin. Res. Pediatr. Endocrinol. 2017;9(2):58–68. https://doi.org/10.4274/jcrpe.2017.s006</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Underbjerg L., Sikjaer T., Mosekilde L., Rejnmark L. Pseudohypoparathyroidism — epidemiology, mortality and risk of complications. Clin. Endocrinol (Oxf.). 2016;84(6):904–911. https://doi.org/10.1111/cen.12948</mixed-citation><mixed-citation xml:lang="en">Underbjerg L., Sikjaer T., Mosekilde L., Rejnmark L. Pseudohypoparathyroidism — epidemiology, mortality and risk of complications. Clin. Endocrinol (Oxf.). 2016;84(6):904–911. https://doi.org/10.1111/cen.12948</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Vatta M., Ackerman M.J., Ye B., Makielski J.C., Ughanze E.E., Taylor E.W., et al. Mutant caveolin­3 induces persistent late sodium current and is associated with long­QT syndrome. Circulation. 2006;114(20):2104–2112. https://doi.org/10.1161/CIRCULATIONAHA.106.635268</mixed-citation><mixed-citation xml:lang="en">Vatta M., Ackerman M.J., Ye B., Makielski J.C., Ughanze E.E., Taylor E.W., et al. Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation. 2006;114(20):2104–2112. https://doi.org/10.1161/CIRCULATIONAHA.106.635268</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Viskin S., Postema P.G., Bhuiyan Z.A., Rosso R., Kalman J.M., Vohra J.K., et al. Te response of the QT interval to the brief tachycardia provoked by standing: A bedside test for diagnosing long QT syndrome. J. Am. Coll. Cardiol. 2010;55(18):1955–1961. https://doi.org/10.1016/j.jacc.2009.12.015</mixed-citation><mixed-citation xml:lang="en">Viskin S., Postema P.G., Bhuiyan Z.A., Rosso R., Kalman J.M., Vohra J.K., et al. The response of the QT interval to the brief tachycardia provoked by standing: A bedside test for diagnosing long QT syndrome. J. Am. Coll. Cardiol. 2010;55(18):1955–1961. https://doi.org/10.1016/j.jacc.2009.12.015</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">World Anti­Doping Agency. Prohibited List, Yanuary 2016 [Internet]. Available at: https://www.fa.com/sites/default/fles/wada­2016­prohibited­list­en_0.pdf (accessed April 24, 2016).</mixed-citation><mixed-citation xml:lang="en">World Anti-Doping Agency. Prohibited List, Yanuary 2016 [Internet]. Available at: https://www.fia.com/sites/default/files/wada-2016-prohibited-list-en_0.pdf (accessed April 24, 2016).</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Wedekind H., Burde D., Zumhagen S., Debus V., Burkhardtsmaier G., Mönnig G., Breithardt G., Schulze-Bahr E. QT interval prolongation and risk for cardiac events in genotyped LQTS­index children. Eur. J. Pediatr. 2009;168(9):1107–1115. https://doi.org/10.1007/s00431­008­0896­6</mixed-citation><mixed-citation xml:lang="en">Wedekind H., Burde D., Zumhagen S., Debus V., Burkhardtsmaier G., Mönnig G., Breithardt G, Schulze-Bahr E. QT interval prolongation and risk for cardiac events in genotyped LQTS-index children. Eur. J. Pediatr. 2009;168(9):1107–1115. https://doi.org/10.1007/s00431-008-0896-6</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Zipes D.P., Ackerman M.J., Estes N.A. 3rd, Grant A.O., Myerburg R.J., Van Hare G. Task Force 7: arrhythmias. J. Am. Coll. Cardiol. 2005;45(8):1354–1363. https://doi.org/10.1016/j.jacc.2005.02.014</mixed-citation><mixed-citation xml:lang="en">Zipes D.P., Ackerman M.J., Estes N.A. 3rd, Grant A.O., Myerburg R.J., Van Hare G. Task Force 7: arrhythmias. J. Am. Coll. Cardiol. 2005;45(8):1354–1363. https://doi.org/10.1016/j.jacc.2005.02.014</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
