smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICON10.47529/2223-2524.2021.4.7smjournal-345Research ArticleФАРМАКОЛОГИЧЕСКАЯ ПОДДЕРЖКАSPORTS PHARMACOLOGYПроблема безопасности курсового приема симпатомиметиков из группы алифатических аминов (геранамин, октодрин, АМП цитрат)The problem of the course reception of sympatomimetics from the group of aliphatic amines safety (geranamine, octodrine, AMP citrate)ЯковлевО. А.YakovlevO. A.

Яковлев Олег Александрович, научный сотрудник

195043, Россия, Санкт-Петербург, ул. Лесопарковая, 4

Oleg A. Yakovlev, researcher

4, Lesoparkovaya str., St. Petersburg, 195043, Russia

gniiivm_15@mail.ruВахвияйненМ. С.VakhviyaynenM. S.

Вахвияйнен Мария Сергеевна, младший научный сотрудник

195043, Россия, Санкт-Петербург, ул. Лесопарковая, 4 

Mariya S. Vakhviyaynen, junior researcher

4, Lesoparkovaya str., St. Petersburg, 195043, Russia

gniiivm_15@mail.ruЮдинМ. А.JudinM. A.

Юдин Михаил Анатольевич, д. м. н., доцент

195043, Россия, Санкт-Петербург, ул. Лесопарковая, 4

Mihail A. Judin, Ph.D. (Medicine), Associate Professor

4, Lesoparkovaya str., St. Petersburg, 195043, Russia

gniiivm_15@mail.ruАнохинА. Г.AnokhinA. G.

Анохин Александр Геннадьевич, к. м. н.

195043, Россия, Санкт-Петербург, ул. Лесопарковая, 4 

Aleksandr G. Anokhin, M.D., Ph.D. (Medicine)

4, Lesoparkovaya str., St. Petersburg, 195043, Russia

gniiivm_15@mail.ruКоноваловА. В.KonovalovA. V.

Коновалов Алексей Владимирович, научный сотрудник

195043, Россия, Санкт-Петербург, ул. Лесопарковая, 4

Aleksei V. Konovalov, researcher

4, Lesoparkovaya str., St. Petersburg, 195043, Russia

gniiivm_15@mail.ruФГБУ «Государственный научно-исследовательский испытательный институт военной медицины» Министерства обороны Российской ФедерацииРоссияState Scientific Research Test Institute of the Military MedicineRussian Federation2021060520221146977Copyright © Яковлев О.А., Вахвияйнен М.С., Юдин М.А., Анохин А.Г., Коновалов А.В., 20222022Яковлев О.А., Вахвияйнен М.С., Юдин М.А., Анохин А.Г., Коновалов А.В.Yakovlev O.A., Vakhviyaynen M.S., Judin M.A., Anokhin A.G., Konovalov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/345

Спортивное питание, используемое с целью снижения веса или повышения работоспособности, может содержать в себе психостимулирующие алифатические амины. Наиболее встречающиеся из них представлены ДМАА, октодрином и АМП цитратом. По вышеперечисленным соединениям отсутствуют токсикометрические данные, что препятствует их доклиническому и клиническому изучению и формированию оптимальных схем приема или алгоритмов терапии передозировки. Мы определили, что все вышеуказанные препараты обладают низкой степенью кумуляции (<20 %). Исходя из свойств данного класса препаратов, курс не должен превышать 7 суток во избежание осложнений и развития зависимости.

Sport nutrition used to reduce weight or improve performance may contain psychostimulant aliphatic amines. The most common of them are DMAA, octodrine and AMP citrate. There are no toxicometric data for above compounds, which prevents their preclinical and clinical study and the formation of optimal dosing regimens or algorithms for overdose therapy. We determined that all of the above drugs have a low degree of cumulation of <20%. Based on the properties of this class of drug, the course should not exceed 7 days in order to avoid complications and the development of addiction.

ДМААгераньоктодринАМП цитратБАДспортивное питаниекумуляциясимпатомиметикипсихостимуляторыDMAAgeraniumoctodrineAMP citratedietary supplementsport nutritioncumulationsympathomimeticspsychostimulantsReferencesCohen P.A. DMAA as a dietary supplement ingredient. Arch. Intern. Med. 2012;172(13):1038–1039. 10.1001/archinternmed.2012.1677Cohen P.A. DMAA as a dietary supplement ingredient. Arch. Intern. Med. 2012;172(13):1038–1039. https://doi.org/10.1001/archinternmed.2012.1677Forrester M. Exposures to 1,3­dimethylamylamine­containing products reported to Texas poison centers. Hum. Exp. Toxicol. 2013;32(1):18–23. https://doi.org/10.1177/0960327112454895Forrester M. Exposures to 1,3­dimethylamylamine­containing products reported to Texas poison centers. Hum. Exp. Toxicol. 2013;32(1):18–23. https://doi.org/10.1177/0960327112454895Планида Е.В. Проблемные вопросы использования в спорте запрещенных субстанций. Ученые записки Белорусского государственного университета физической культуры. 2019;22:241–247.Planida E.V. Problems of prohibited substances use in sport. Uchenye zapiski Belorusskogo gosudarstvennogo universiteta fzicheskoi kul’tury [Scientifc notes of the Belarusian State University of Physical Culture]. 2019;22:241–247 (In Russ.).Gee P., Jackson S., Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N. Z. Med. J. 2010;123(1327):124–127.Gee P., Jackson S., Easton J. Another bitter pill: a case of toxicity from DMAA party pills. N. Z. Med. J. 2010;123(1327):124–127.Salinger L., Daniels B., Sangalli B., Bayer M. Recreational use of a body­building supplement resulting in severe cardiotoxicity. Clinical Toxicology. 2011;49:573–574.Salinger L., Daniels B., Sangalli B., Bayer M. Recreational use of a body­building supplement resulting in severe cardiotoxicity. Clinical Toxicology. 2011;49:573–574.McCarthy C.G., Farney T.M., Canale R.E., Alleman R.J. Jr., Bloomer R.J. A fnished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr. Metab. Insights. 2012;5:23–31. https://doi.org/10.4137/NMI.S8567McCarthy C.G., Farney T.M., Canale R.E., Alleman R.J. Jr., Bloomer R.J. A fnished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr. Metab. Insights. 2012;5:23–31. https://doi.org/10.4137/NMI.S8567Bloomer R.J., Harvey I.C., Farney T.M., Bell Z.W., Canale R.E. Effects of 1,3­dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. Phys. Sportsmed. 2011;39(3):111–120. https://doi.org/10.3810/psm.2011.09.1927Bloomer R.J., Harvey I.C., Farney T.M., Bell Z.W., Canale R.E. Effects of 1,3­dimethylamylamine and caffeine alone or in combination on heart rate and blood pressure in healthy men and women. Phys. Sportsmed. 2011;39(3):111–120. https://doi.org/10.3810/psm.2011.09.1927Rickli A., Hoener M.C., Liechti M.E. Pharmacological profles of compounds in preworkout supplements (“boosters”). Eur. J. Pharmacol. 2019;859:172515. https://doi.org/10.1016/j.ejphar.2019.172515Rickli A., Hoener M.C., Liechti M.E. Pharmacological profles of compounds in preworkout supplements (“boosters”). Eur. J. Pharmacol. 2019;859:172515. https://doi.org/10.1016/j.ejphar.2019.172515Nurminen M.L., Niittynen L., Korpela R., Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur. J. Clin. Nutr. 1999;53(11):831–839. https://doi.org/10.1038/sj.ejcn.1600899Nurminen M.L., Niittynen L., Korpela R., Vapaatalo H. Coffee, caffeine and blood pressure: a critical review. Eur. J. Clin. Nutr. 1999;53(11):831–839. https://doi.org/10.1038/sj.ejcn.1600899Dolan S.B., Gatch M.B. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015;146:97–102. https://doi.org/10.1016/j.drugalcdep.2014.11.006Dolan S.B., Gatch M.B. Abuse liability of the dietary supplement dimethylamylamine. Drug Alcohol Depend. 2015;146:97–102. https://doi.org/10.1016/j.drugalcdep.2014.11.00611.Павлова О.Ю. Влияние применения и отмены 1,3­диметиламина (ДМАА) на поведение крыс. В: Проблемы медицины и биологии: материалы международной научнопрактической конференции молодых ученых и студентов. Ч. 2. Кемерово: КемГМУ; 2020. с. 89–90.Pavlova О.Yu. Effect of 1,3­dimethylamine (DMAA) administration and withdrawal on rat behavior. In: Problems of medicine and biology: Materials of the international scientifc­practical conference of young scientists and students. Part 2. Kemerovo: Kemerovo State Medical University; 2020. c. 89–90 (In Russ.).Fontana R.J. Severe Acute Hepatitis Attributed to the Herbal and Dietary Supplement OxyELITE Pro. Clin. Liver Dis. (Hoboken). 2019;14(2):45–48. https://doi.org/10.1002/cld.809Fontana R.J. Severe Acute Hepatitis Attributed to the Herbal and Dietary Supplement OxyELITE Pro. Clin. Liver Dis. (Hoboken). 2019;14(2):45–48. https://doi.org/10.1002/cld.809Foley S., Butlin E., Shields W., Lacey B. Experience with OxyELITE pro and acute liver injury in active duty service members. Dig. Dis. Sci. 2014;59(12):3117–3121. https://doi.org/10.1007/s10620­014­3221­4Foley S., Butlin E., Shields W., Lacey B. Experience with OxyELITE pro and acute liver injury in active duty service members. Dig. Dis. Sci. 2014;59(12):3117–3121. https://doi.org/10.1007/s10620­014­3221­4Heidemann L.A., Navarro V.J., Ahmad J., Hayashi P.H., Stolz A., Kleiner D. E., et al. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series. Dig. Dis. Sci. 2016;61(9):2741–2748. https://doi.org/10.1007/s10620­016­4181­7Heidemann L.A., Navarro V.J., Ahmad J., Hayashi P.H., Stolz A., Kleiner D. E., et al. Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series. Dig. Dis. Sci. 2016;61(9):2741–2748. https://doi.org/10.1007/s10620­016­4181­7Kuo C.L., Wang R.B., Shen L.J., Lien L.L., Lien E.J. G­protein coupled receptors: SAR analyses of neurotransmitters and antagonists. J. Clin. Pharm. Ter. 2004;29 (3):279–298. https://doi.org/10.1111/j.1365­2710.2004.00563.xKuo C.L., Wang R.B., Shen L.J., Lien L.L., Lien E.J. Gprotein coupled receptors: SAR analyses of neurotransmitters and antagonists. J. Clin. Pharm. Ter. 2004;29 (3):279–298. https://doi.org/10.1111/j.1365­2710.2004.00563.xSchlessinger A., Geier E., Fan H., Irwin J.J., Shoichet B.K., Giacomini K. M., et al. Structure­based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc. Natl. Acad. Sci. U S A. 2011;108(38):15810–15815. https://doi.org/10.1073/pnas.1106030108Schlessinger A., Geier E., Fan H., Irwin J. J., Shoichet B.K., Giacomini K. M., et al. Structure­based discovery of prescription drugs that interact with the norepinephrine transporter, NET. Proc. Natl. Acad. Sci. U S A. 2011;108(38):15810–15815. https://doi.org/10.1073/pnas.110603010817.Микшта А.Ю., Эрдниев Л.П., Власов А.А., Леготин И.В., Ермолаева И.А., Комиссаренко С.А., и др. Возможности сохранения работоспособности при отравлениях фосфоророрганическими соединениями. Вестник войск РХБ защиты. 2019;3(4):311–318.Mikshta A. Yu., Erdniev L.P., Vlasov A.A., Legotin I.V. Ermolaeva I.A., et al. Possibilities of maintaining efciency in case of poisoning with organophosphorus compounds. Vestnik voisk RKhB zashchity = Journal of NBC Protection corps. 2019;3(4):311–318 (In Russ.).Catalani V., Prilutskaya M., Al-Imam A., Marrinan S., Elgharably Y., Zloh M., et al. Octodrine: New Questions and Challenges in Sport Supplements. Brain Sci. 2018;8(2):34. https://doi.org/10.3390/brainsci8020034Catalani V., Prilutskaya M., Al-Imam A., Marrinan S., Elgharably Y., Zloh M., et al. Octodrine: New Questions and Challenges in Sport Supplements. Brain Sci. 2018;8(2):34. https://doi.org/10.3390/brainsci8020034Cohen P.A., Travis J.C., Venhuis B.J. A synthetic stimulant never tested in humans, 1,3­dimethylbutylamine (DMBA), is identifed in multiple dietary supplements. Drug Test. Anal. 2015;7(1):83–87. https://doi.org/10.1002/dta.1735Cohen P.A., Travis J.C., Venhuis B.J. A synthetic stimulant never tested in humans, 1,3­dimethylbutylamine (DMBA), is identifed in multiple dietary supplements. Drug Test. Anal. 2015;7(1):83–87. https://doi.org/10.1002/dta.1735Wang S.Y., Song Y., Xu M., He Q.H., Han Q.D., Zhang Y.Y. Internalization and distribution of three alpha1­adrenoceptor subtypes in HEK293A cells before and afer agonist stimulation. Acta Pharmacol. Sin. 2007;28(3):359–366. https://doi.org/10.1111/j.1745­7254.2007.00509.xWang S.Y., Song Y., Xu M., He Q.H., Han Q.D., Zhang Y.Y. Internalization and distribution of three alpha1­adrenoceptor subtypes in HEK293A cells before and afer agonist stimulation. Acta Pharmacol. Sin. 2007;28(3):359–366. https://doi.org/10.1111/j.1745­7254.2007.00509.xVincent J., Dachman W., Blaschke T.F., Hoffman B.B. Pharmacological tolerance to alpha 1­adrenergic receptor antagonism mediated by terazosin in humans. J. Clin. Invest. 1992;90(5):1763–1768. https://doi.org/10.1172/JCI116050Vincent J., Dachman W., Blaschke T.F., Hoffman B.B. Pharmacological tolerance to alpha 1­adrenergic receptor antagonism mediated by terazosin in humans. J. Clin. Invest. 1992;90(5):1763–1768. https://doi.org/10.1172/JCI116050Graf P., Hallén H., Juto J. E. Four­week use of oxymetazoline nasal spray (Nezeril) once daily at night induces rebound swelling and nasal hyperreactivity. Acta Otolaryngol. 1995;115(1):71–75. https://doi.org/10.3109/00016489509133350Graf P., Hallén H., Juto J.E. Four­week use of oxymetazoline nasal spray (Nezeril) once daily at night induces rebound swelling and nasal hyperreactivity. Acta Otolaryngol. 1995;115(1):71–75. https://doi.org/10.3109/00016489509133350Graf P., Hallén H. [Daily administration of nose drops can cause chronic nasal congestion]. Lakartidningen. 1996;93(4):259–262.Graf P., Hallén H. [Daily administration of nose drops can cause chronic nasal congestion]. Lakartidningen. 1996;93(4):259–262.Mortuaire G., de Gabory L., François M., Massé G., Bloch F., Brion N., et al. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur. Ann. Otorhinolaryngol. Head Neck Dis. 2013;130(3):137–144. https://doi.org/10.1016/j.anorl.2012.09.005Mortuaire G., de Gabory L., François M., Massé G., Bloch F., Brion N., et al. Rebound congestion and rhinitis medicamentosa: nasal decongestants in clinical practice. Critical review of the literature by a medical panel. Eur. Ann. Otorhinolaryngol. Head Neck Dis. 2013;130(3):137–144. https://doi.org/10.1016/j.anorl.2012.09.005Graf P. Long­term use of oxy­ and xylometazoline nasal sprays induces rebound swelling, tolerance, and nasal hyperreactivity. Rhinology. 1996;34(1):9–13.Graf P. Long­term use of oxy­ and xylometazoline nasal sprays induces rebound swelling, tolerance, and nasal hyperreactivity. Rhinology. 1996;34(1):9–13.Schilling B.K., Hammond K.G., Bloomer R.J., Presley C.S., Yates C.R. Physiological and pharmacokinetic effects of oral 1,3­dimethylamylamine administration in men. BMC Pharmacol. Toxicol. 2013;14:52. https://doi.org/10.1186/2050­6511­14­52Schilling B.K., Hammond K.G., Bloomer R.J., Presley C.S., Yates C.R. Physiological and pharmacokinetic effects of oral 1,3­dimethylamylamine administration in men. BMC Pharmacol. Toxicol. 2013;14:52. https://doi.org/10.1186/2050­6511­14­52Миронов А., ред. Руководство по проведению доклинических исследований лекарственных средств. Часть первая Москва: Гриф и К; 2012.Mironov A., ed. Guidelines for preclinical assessment of drug. Vol 1, Moscow: Grif i K Publ.; 2012 (In Russ.).Толоконцев Н., Филов В. Основы промышленной токсикологии (руководство). Ленинград: Медицина; 1976.Tolokoncev N., Filov V. Basics of industrial toxicology (Guide). Leningrad: Meditsina; 1976 (In Russ.).Гуськова Т. Токсикология лекарственных средств. Москва: МВД; 2003Gus`kova T. Drugs toxicology. Moscow: MVD Publ.; 2003 (In Russ.).

The authors declare that there are no conflicts of interest present.