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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">smjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Спортивная медицина: наука и практика</journal-title><trans-title-group xml:lang="en"><trans-title>Sports medicine: research and practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2223-2524</issn><issn pub-type="epub">2587-9014</issn><publisher><publisher-name>NEICON</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47529/2223-2524.2022.1.1</article-id><article-id custom-type="elpub" pub-id-type="custom">smjournal-382</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>РЕАБИЛИТАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REHABILITATION</subject></subj-group></article-categories><title-group><article-title>Эффективность физических нагрузок в кардиореабилитации</article-title><trans-title-group xml:lang="en"><trans-title>The effectiveness of physical activity in cardiorehabilitation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5260-8304</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлев</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovlev</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яковлев Максим Юрьевич, к.м.н., руководитель центра организации медицинской реабилитации</p><p>121099, Москва, ул. Новый Арбат, 32</p></bio><bio xml:lang="en"><p>Maxim Yu. Yakovlev, Ph.D. (Medicine), Head of National Medical Research Center of Rehabilitation and Balneology of the Ministry of Health of the Russian Federation</p><p>32, Novy Arbat str., Moscow, 121099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4435-2273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>О. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>O. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедева Ольга Даниловна, д.м.н., главный научный сотрудник, профессор кафедры физической терапии и медицинской реабилитации</p><p>121099, Москва, ул. Новый Арбат, 32</p></bio><bio xml:lang="en"><p>Olga D. Lebedeva, M.D., D.Sc. (Medicine), Leading Researcher, Professor of the Department of Physiotherapy and Reflexology</p><p>32, Novy Arbat str., Moscow, 121099</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Владимирский</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Vladimirsky</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимирский Владимир Евгеньевич, д.м.н., профессор</p><p>614068, Россия, Пермь, ул. Плеханова, 36</p></bio><bio xml:lang="en"><p>Vladimir E. Vladimirsky, D.Sс. (Medicine), Professor</p><p>36, Plexanov str., Perm, 614068</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4199-1931</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Владимирский</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vladimirsky</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владимирский Евгений Владимирович, д.м.н., заведующий кафедрой факультетской терапии №1</p><p>614068, Россия, Пермь, ул. Плеханова, 36</p></bio><bio xml:lang="en"><p>Evgeniy V. Vladimirsky, D.Sс. (Medicine), Head of the Department of Faculty Therapy No. 1</p><p>36, Plexanov str., Perm, 614068</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лунина</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lunina</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лунина Анна Николаевна, ассистент</p><p>614068, Россия, Пермь, ул. Плеханова, 36</p></bio><bio xml:lang="en"><p>Anna N. Lunina, Assistant</p><p>36, Plexanov str., Perm, 614068</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр реабилитации и курортологии» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Institution “National Medical Research Center of Rehabilitation and Balneology” of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Пермский государственный медицинский университет имени академика Е.А. Вагнера» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Perm State Medical University named after Academician E. A. Wagner</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>30</day><month>04</month><year>2022</year></pub-date><volume>12</volume><issue>1</issue><fpage>37</fpage><lpage>46</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Яковлев М.Ю., Лебедева О.Д., Владимирский В.Е., Владимирский Е.В., Лунина А.Н., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Яковлев М.Ю., Лебедева О.Д., Владимирский В.Е., Владимирский Е.В., Лунина А.Н.</copyright-holder><copyright-holder xml:lang="en">Yakovlev M.Y., Lebedeva O.D., Vladimirsky V.E., Vladimirsky E.V., Lunina A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.smjournal.ru/jour/article/view/382">https://www.smjournal.ru/jour/article/view/382</self-uri><abstract><p>В обзоре показано, что молекулярные механизмы, инициируемые физическими нагрузками, лежат в основе многофакторного влияния последних на функцию сердечно-сосудистой системы и течение кардиальных заболеваний. Физические упражнения являются важным компонентом терапевтического лечения пациентов с сердечно-сосудистыми заболеваниями, что подтверждают результаты метаанализа, включавшего 63 исследования, которые были связаны с различными формами аэробных упражнений разной интенсивности (от 50 до 95 % VO2) в течение от 1 до 47 месяцев, и показавшего, что кардиореабилитация на основе физических упражнений улучшает сердечно-сосудистую функцию. Знание молекулярных основ влияния физических нагрузок дает возможность использовать биохимические маркеры для оценки эффективности реабилитационных программ.</p></abstract><trans-abstract xml:lang="en"><p>The review shows that the molecular mechanisms initiated by physical exertion underlie the multifactorial influence of the latter on the function of the cardiovascular system and the course of cardiac diseases. Exercise is an important component of the therapeutic treatment in patients with cardiovascular diseases, which is confirmed by the results of a meta­analysis that included 63 studies that were associated with various forms of aerobic exercise of different intensity (from 50 to 95 % VO2) for 1 to 47 months, which showed that exercise-based CR improves cardiovascular function. Knowledge of the molecular basis of the impact of physical activity makes it possible to use biochemical markers to assess the effectiveness of rehabilitation programs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиореабилитация</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>физические нагрузки</kwd><kwd>молекулярные механизмы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiorehabilitation</kwd><kwd>cardiovascular diseases</kwd><kwd>physical activity</kwd><kwd>molecular mechanisms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas R.J., King M., Lui K., Oldridge N., Pina I.L., Spertus J. AACVPR/ACC/AHA 2007 Performance Measures on Cardiac Rehabilitation for Referral to and Delivery of Cardiac Rehabilitation/Secondary Prevention Services. J. Cardiopulm. Rehabil. Prev 2007;27(5):260–290. https://doi.org/10.1097/01.hcr.0000291295.24776.7b</mixed-citation><mixed-citation xml:lang="en">Thomas R.J., King M., Lui K., Oldridge N., Pina I.L., Spertus J. AACVPR/ACC/AHA 2007 Performance Measures on Cardiac Rehabilitation for Referral to and Delivery of Cardiac Rehabilitation/Secondary Prevention Services. J. Cardiopulm. Rehabil. Prev 2007;27(5):260–290. https://doi.org/10.1097/01.hcr.0000291295.24776.7b</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Piepoli M.F., Corra U., Benzer W., Bjarnason-Wehrens B., Dendale P., Gaitaetal D., et al. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur. J. Cardiovasc. 2010;17(1):1–17. https://doi.org/10.1097/hjr.0b013e3283313592</mixed-citation><mixed-citation xml:lang="en">Piepoli M.F., Corra U., Benzer W., Bjarnason-Wehrens B., Dendale P., Gaitaetal D., et al. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur. J. Cardiovasc. 2010;17(1):1–17. https://doi.org/10.1097/hjr.0b013e3283313592</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Исмайлов И.С., Мамедьярова И.А., Баранов А.В., Мустафаев Р.Д., Лебедева О.Д., Ачилов А.А. Сочетанное применение кинезо- и лазеротерапии в коррекции нарушений регионарной гемодинамики при дилатационной кардиомиопатии. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2020;97(5):13–21. https://doi.org/10.17116/kurort20209705113</mixed-citation><mixed-citation xml:lang="en">Ismaylov I. S., Mamedyarova I. A., Baranov A.V., Mustafaev R. D., Lebedeva O. D., Achilov A. A. Combined use of kineso- and laser therapy in the correction of regional hemodynamic disorders in dilated cardiomyopathy. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury. 2020;97(5):13–21 (In Russ.). https://doi.org/10.17116/kurort20209705113</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Corbalan R., Bassand J.P., Illingworth L., Kayani G., Pieper K.S., Ambrosio G., et al. Analysis of outcomes in ischemic vs nonischemic cardiomyopathy in patients with atrial fibrillation: a report from the garfield-af registry. JAMA Cardiology. 2019;4(6):526–548. https://doi.org/10.1001/jamacardio.2018.4729</mixed-citation><mixed-citation xml:lang="en">Corbalan R., Bassand J.P., Illingworth L., Kayani G., Pieper K.S., Ambrosio G., et al. Analysis of outcomes in ischemic vs nonischemic cardiomyopathy in patients with atrial fibrillation: a report from the garfield-af registry. JAMA Cardiology. 2019;4(6):526–548. https://doi.org/10.1001/jamacardio.2018.4729</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Haas S., Cate H.T., Accetta G., Bassand J.P., Kayani G., Kakkar A.K., et al. Quality of vitamin k antagonist control and 1-year outcomes in patients with atrial fibrillation: a global perspective from the garfield-af registry. PLoSONE. 2016;11(10):e0164076. https://doi.org/10.1371/journal.pone.0164076</mixed-citation><mixed-citation xml:lang="en">Haas S., Cate H.T., Accetta G., Bassand J.P., Kayani G., Kakkar A.K., et al. Quality of vitamin k antagonist control and 1-year outcomes in patients with atrial fibrillation: a global perspective from the garfield-af registry. PLoSONE. 2016;11(10):e0164076. https://doi.org/10.1371/journal.pone.0164076</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sawhney J.P., Kothiwale V.A., Bisne V., Durgaprasad R., Vanajakshamma V., Jadhav P., et al. Risk Profiles And One-Year Outcomes Of Patients With Newly Diagnosed Atrial Fibrillation In India: Insights From The Garfield-Af Registry. Indian Heart J. 2018;70(6):828–835. https://doi.org/10.1016/j.ihj.2018.09.001</mixed-citation><mixed-citation xml:lang="en">Sawhney J.P., Kothiwale V.A., Bisne V., Durgaprasad R., Vanajakshamma V., Jadhav P., et al. Risk Profiles And One-Year Outcomes Of Patients With Newly Diagnosed Atrial Fibrillation In India: Insights From The Garfield-Af Registry. Indian Heart J. 2018;70(6):828–835. https://doi.org/10.1016/j.ihj.2018.09.001</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дмитриев В.К., Радзиевский С.А., Фисенко Л.А., Алексеев В.В., Лебедева О.Д. Церебрально-вегетативные аспекты лабильной гипертонии. Кардиология. 1988;(12):20–23.</mixed-citation><mixed-citation xml:lang="en">Dmitriev V.K., Radzievsky S.A., Fisenko L.A., Alekseev V.V., Lebedeva O.D. Cerebral and autonomic aspects of labile hypertension. Kardiologiia = Cardiology. 1988;(12):20–23 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Дмитриев В.К., Радзиевский С.А., Фисенко Л.А., Лебедева О.Д. Церебрально-вегетативные соотношения у больных гипертонической болезнью ранних стадий в процессе рефлексотерапии. Кардиология.1990;(1):35–38.</mixed-citation><mixed-citation xml:lang="en">Dmitriev V.K., Radzievsky S.A., Fisenko L.A., Lebedeva O.D. Cerebral-vegetative relations in patients with early-stage hypertension in the process of reflexotherapy. Kardiologiia = Cardiology. 1990;(1):35–38 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Никифорова Т.И., Лебедева О.Д., Рыков С.В., Белов А.С. Современные комплексные технологии реабилитации и профилактики у больных артериальной гипертензией. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2013;90(6):52–58.</mixed-citation><mixed-citation xml:lang="en">Nikiforova T.I., Lebedeva O.D., Rykov S.V., Belov A.S. Modern complex technologies of rehabilitation and prevention in patients with arterial hypertension. Voprosy kurortologii, fizioterapii i lechebnoi fizicheskoi kul’tury. 2013;90(6):52–58 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ehrman J.K., Gordon P.M., Visich P.S., Keteyian S.J. Clinical exercise phisiology. 1st ed. Champaign, IL: Human Kinetics; 2003.</mixed-citation><mixed-citation xml:lang="en">Ehrman J.K., Gordon P.M., Visich P.S., Keteyian S.J. Clinical exercise phisiology. 1st ed. Champaign, IL: Human Kinetics; 2003.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Jardins T. Cardiopulmonary anatomy &amp; physiology essentials for respiratory care. 4th ed. Clifton Park, NY: Thomson Delmar Learning; 2002.</mixed-citation><mixed-citation xml:lang="en">Jardins T. Cardiopulmonary anatomy &amp; physiology essentials for respiratory care. 4th ed. Clifton Park, NY: Thomson Delmar Learning; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mancini D.M., Henson D., La Manca J., Donchez L., Levine S. Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Circulation. 1995;91(2):320–329. https://doi.org/10.1161/01.cir.91.2.320</mixed-citation><mixed-citation xml:lang="en">Mancini D.M., Henson D., La Manca J., Donchez L., Levine S. Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Circulation. 1995;91(2):320–329. https://doi.org/10.1161/01.cir.91.2.320</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Stanford K.I., Goodyear L.J. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv. Physio.l Educ. 2014;38(4):308–314. https://doi.org/10.1152/advan.00080.2014</mixed-citation><mixed-citation xml:lang="en">Stanford K.I., Goodyear L.J. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv. Physio.l Educ. 2014;38(4):308–314. https://doi.org/10.1152/advan.00080.2014</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nystoriak M.A., Bhatnagar A. Cardiovascular Effects and Benefits of Exercise. Front. Cardiovasc. Med. 2018;5:135. https://doi.org/10.3389/fcvm.2018.00135</mixed-citation><mixed-citation xml:lang="en">Nystoriak M.A., Bhatnagar A. Cardiovascular Effects and Benefits of Exercise. Front. Cardiovasc. Med. 2018;5:135. https://doi.org/10.3389/fcvm.2018.00135</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Egan B., Zierath J.R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17(2):162–184. https://doi.org/10.1016/j.cmet.2012.12.012</mixed-citation><mixed-citation xml:lang="en">Egan B., Zierath J.R. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metab. 2013;17(2):162–184. https://doi.org/10.1016/j.cmet.2012.12.012</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Slentz C.A., Bateman L.A., Willis L.H., Granville E.O., Piner L.W., Samsa G.P., et al. Effects of exercise training alone vs. a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial. Diabetologia. 2016;59(10):2088–2098. https://doi.org/10.1007/s00125-016-4051-z</mixed-citation><mixed-citation xml:lang="en">Slentz C.A., Bateman L.A., Willis L.H., Granville E.O., Piner L.W., Samsa G.P., et al. Effects of exercise training alone vs. a combined exercise and nutritional lifestyle intervention on glucose homeostasis in prediabetic individuals: a randomised controlled trial. Diabetologia. 2016;59(10):2088–2098. https://doi.org/10.1007/s00125-016-4051-z</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Conn V.S., Koopman R.J., Ruppar T.M., Phillips L.J., Mehr D.R., Hafdahl A.R. Insulin sensitivity following exercise interventions: systematic review and meta-analysis of outcomes among healthy adults. J. Prim. Care Community Health. 2014;5(3):211–222. https://doi.org/10.1177/2150131913520328</mixed-citation><mixed-citation xml:lang="en">Conn V.S., Koopman R.J., Ruppar T.M., Phillips L.J., Mehr D.R., Hafdahl A.R. Insulin sensitivity following exercise interventions: systematic review and meta-analysis of outcomes among healthy adults. J. Prim. Care Community Health. 2014;5(3):211–222. https://doi.org/10.1177/2150131913520328</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lin X., Zhang X., Guo J., Roberts C.K., McKenzie S., Wu W.C., et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. J. Am. Heart Assoc. 2015;4(7):e002014. https://doi.org/10.1161/JAHA.115.002014</mixed-citation><mixed-citation xml:lang="en">Lin X., Zhang X., Guo J., Roberts C.K., McKenzie S., Wu W.C., et al. Effects of exercise training on cardiorespiratory fitness and biomarkers of cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials. J. Am. Heart Assoc. 2015;4(7):e002014. https://doi.org/10.1161/JAHA.115.002014</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Petridou A., Nikolaidis M.G., Matsakas A., Schulz T., Michna H., Mougios V. Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue. Eur. J. Appl. Physiol. 2005;94(1-2):84–92. https://doi.org/10.1007/s00421-004-1294-z</mixed-citation><mixed-citation xml:lang="en">Petridou A., Nikolaidis M.G., Matsakas A., Schulz T., Michna H., Mougios V. Effect of exercise training on the fatty acid composition of lipid classes in rat liver, skeletal muscle, and adipose tissue. Eur. J. Appl. Physiol. 2005;94(1-2):84–92. https://doi.org/10.1007/s00421-004-1294-z</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fiuza-Luces C., Garatachea N., Berger N.A., Lucia A. Exercise is the real polypill. Physiology. 2013;28(5):330–358. https://doi.org/10.1152/physiol.00019.2013</mixed-citation><mixed-citation xml:lang="en">Fiuza-Luces C., Garatachea N., Berger N.A., Lucia A. Exercise is the real polypill. Physiology. 2013;28(5):330–358. https://doi.org/10.1152/physiol.00019.2013</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Che L., Li D. The effects of exercise on cardiovascular biomarkers: new Insights, recent data, and applications. Adv. Exp. Med. Biol. 2017;999:43–53. https://doi.org/10.1007/978-981-104307-9_3</mixed-citation><mixed-citation xml:lang="en">Che L., Li D. The effects of exercise on cardiovascular biomarkers: new Insights, recent data, and applications. Adv. Exp. Med. Biol. 2017;999:43–53. https://doi.org/10.1007/978-981-10-43079_3</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fontana L. Interventions to promote cardiometabolic health and slow cardiovascular ageing. Nat. Rev. Cardiol. 2018;15(9):566–577. https://doi.org/10.1038/s41569-018-0026-8</mixed-citation><mixed-citation xml:lang="en">Fontana L. Interventions to promote cardiometabolic health and slow cardiovascular ageing. Nat. Rev. Cardiol. 2018;15(9):566–577. https://doi.org/10.1038/s41569-018-0026-8</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Swift D.L., Johannsen N.M., Lavie C.J., Earnest C.P., Church T.S. The role of exercise and physical activity in weight loss and maintenance. Progr. Cardiovasc. Dis. 2014;56(4):441–447. https://doi.org/10.1016/j.pcad.2013.09.012</mixed-citation><mixed-citation xml:lang="en">Swift D.L., Johannsen N.M., Lavie C.J., Earnest C.P., Church T.S. The role of exercise and physical activity in weight loss and maintenance. Progr. Cardiovasc. Dis. 2014;56(4):441–447. https://doi.org/10.1016/j.pcad.2013.09.012</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Duscha B.D., Slentz C.A., Johnson J.L., Houmard J.A., Bensimhon D.R., Knetzger K.J., et al. Effects of exercise training amount and intensity on peak oxygen consumption in middleage men and women at risk for cardiovascular disease. Chest. 2005;128(4):2788–2793. https://doi.org/10.1378/chest.128.4.2788</mixed-citation><mixed-citation xml:lang="en">Duscha B.D., Slentz C.A., Johnson J.L., Houmard J.A., Bensimhon D.R., Knetzger K.J., et al. Effects of exercise training amount and intensity on peak oxygen consumption in middleage men and women at risk for cardiovascular disease. Chest. 2005;128(4):2788–2793. https://doi.org/10.1378/chest.128.4.2788</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Vega R.B., Konhilas J.P, Kelly D.P., Leinwand L.A. Molecular mechanisms underlying cardiac adaptation to exercise. Cell Metab. 2017;25(5):1012–1026. https://doi.org/10.1016/j.cmet.2017.04.025</mixed-citation><mixed-citation xml:lang="en">Vega R.B., Konhilas J.P, Kelly D.P., Leinwand L.A. Molecular mechanisms underlying cardiac adaptation to exercise. Cell Metab. 2017;25(5):1012–1026. https://doi.org/10.1016/j.cmet.2017.04.025</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Stanford K.I., Goodyear L.J. Exercise regulation of adipose tissue. Adipocyte. 2016;5(2):153–162. https://doi.org/10.1080/21623945.2016.1191307</mixed-citation><mixed-citation xml:lang="en">Stanford K.I., Goodyear L.J. Exercise regulation of adipose tissue. Adipocyte. 2016;5(2):153–162. https://doi.org/10.1080/21623945.2016.1191307</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Vettor R., Valerio A., Ragni M., Trevellin E., Granzotto M., Olivieri M., et al. Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 2014;306(5):E519– 528. https://doi.org/10.1152/ajpendo.00617.2013</mixed-citation><mixed-citation xml:lang="en">Vettor R., Valerio A., Ragni M., Trevellin E., Granzotto M., Olivieri M., et al. Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism. Am. J. Physiol. Endocrinol. Metab. 2014;306(5):E519– 528. https://doi.org/10.1152/ajpendo.00617.2013</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Borges J.P., da Silva Verdoorn K. Cardiac ischemia/reperfusion injury: the beneficial effects of exercise. Adv. Exp. Med. Biol. 2017;999:155–179. https://doi.org/10.1007/978-981-10-4307-9_10</mixed-citation><mixed-citation xml:lang="en">Borges J.P., da Silva Verdoorn K. Cardiac ischemia/reperfusion injury: the beneficial effects of exercise. Adv. Exp. Med. Biol. 2017;999:155–179. https://doi.org/10.1007/978-981-10-4307-9_10</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers A systematic review. J. Am. Coll. Cardiol. 2005;45(10):1563–1569. https://doi.org/10.1016/j.jacc.2004.12.077</mixed-citation><mixed-citation xml:lang="en">Kasapis C., Thompson P.D. The effects of physical activity on serum C-reactive protein and inflammatory markers A systematic review. J. Am. Coll. Cardiol. 2005;45(10):1563–1569. https://doi.org/10.1016/j.jacc.2004.12.077</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Joki Y., Ohashi K., Yuasa D., Shibata R., Kataoka Y., Kambara T., et al. Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction. Circ. Heart. Fail. 2015;8(2):342–351. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001647</mixed-citation><mixed-citation xml:lang="en">Joki Y., Ohashi K., Yuasa D., Shibata R., Kataoka Y., Kambara T., et al. Neuron-derived neurotrophic factor ameliorates adverse cardiac remodeling after experimental myocardial infarction. Circ. Heart. Fail. 2015;8(2):342–351. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001647</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Irving B.A., Lanza I.R., Henderson G.C., Rao R.R., Spiegelman B.M., Nair K.S. Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J. Clin. Endocrinol. Metab. 2015;100(4):1654–1663. https://doi.org/10.1210/jc.2014-3081</mixed-citation><mixed-citation xml:lang="en">Irving B.A., Lanza I.R., Henderson G.C., Rao R.R., Spiegelman B.M., Nair K.S. Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. J. Clin. Endocrinol. Metab. 2015;100(4):1654–1663. https://doi.org/10.1210/jc.2014-3081</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Konopka A.R., Suer M.K., Wolff C.A., Harber M.P. Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J. Gerontol. A Biol. Sci. Med. Sci. 2014;69(4):371–378. https://doi.org/10.1093/gerona/glt107</mixed-citation><mixed-citation xml:lang="en">Konopka A.R., Suer M.K., Wolff C.A., Harber M.P. Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J. Gerontol. A Biol. Sci. Med. Sci. 2014;69(4):371–378. https://doi.org/10.1093/gerona/glt107</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Vella C.A., Ontiveros D., Zubia R.Y. Cardiac function and arteriovenous oxygen difference during exercise in obese adults. Eur. J. Appl. Physiol. 2011 ;111(6):915–923. https://doi.org/10.1007/s00421-010-1554-z</mixed-citation><mixed-citation xml:lang="en">Vella C.A., Ontiveros D., Zubia R.Y. Cardiac function and arteriovenous oxygen difference during exercise in obese adults. Eur. J. Appl. Physiol. 2011 ;111(6):915–923. https://doi.org/10.1007/s00421-010-1554-z</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Tao L., Bei Y., Lin S., Zhang H., Zhou Y., Jiang J., et al. Exercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesis. Cell. Physiol. Biochem. 2015;37(1):162–175. https://doi.org/10.1159/000430342</mixed-citation><mixed-citation xml:lang="en">Tao L., Bei Y., Lin S., Zhang H., Zhou Y., Jiang J., et al. Exercise training protects against acute myocardial infarction via improving myocardial energy metabolism and mitochondrial biogenesis. Cell. Physiol. Biochem. 2015;37(1):162–175. https://doi.org/10.1159/000430342</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Doenst T., Nguyen T.D., Abel E.D. Cardiac metabolism in heart failure: implications beyond ATP production. Circ. Res. 2013 ;113(6):709–724. https://doi.org/10.1161/CIRCRESAHA.113.300376</mixed-citation><mixed-citation xml:lang="en">Doenst T., Nguyen T.D., Abel E.D. Cardiac metabolism in heart failure: implications beyond ATP production. Circ. Res. 2013 ;113(6):709–724. https://doi.org/10.1161/CIRCRESAHA.113.300376</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Velez M., Kohli S., Sabbah H.N. Animal models of insulin resistance and heart failure. Heart Fail. Rev. 2014;19(1):1–13. https://doi.org/10.1007/s10741-013-9387-6</mixed-citation><mixed-citation xml:lang="en">Velez M., Kohli S., Sabbah H.N. Animal models of insulin resistance and heart failure. Heart Fail. Rev. 2014;19(1):1–13. https://doi.org/10.1007/s10741-013-9387-6</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Bird S.R., Hawley J.A. Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc. Med. 2016;2(1):e000143. https://doi.org/10.1136/bmjsem-2016-000143</mixed-citation><mixed-citation xml:lang="en">Bird S.R., Hawley J.A. Update on the effects of physical activity on insulin sensitivity in humans. BMJ Open Sport Exerc. Med. 2016;2(1):e000143. https://doi.org/10.1136/bmjsem-2016-000143</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Riehle C., Abel E.D. Insulin signaling and heart failure. Circ. Res. 2016;118(7):1151–1169. https://doi.org/10.1161/CIRCRESAHA.116.306206</mixed-citation><mixed-citation xml:lang="en">Riehle C., Abel E.D. Insulin signaling and heart failure. Circ. Res. 2016;118(7):1151–1169. https://doi.org/10.1161/CIRCRESAHA.116.306206</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Incalza M.A., D’Oria R., Natalicchio A., Perrini S., Laviola L., Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascul. Pharmacol. 2018;100:1–19. https://doi.org/10.1016/j.vph.2017.05.005</mixed-citation><mixed-citation xml:lang="en">Incalza M.A., D’Oria R., Natalicchio A., Perrini S., Laviola L., Giorgino F. Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases. Vascul. Pharmacol. 2018;100:1–19. https://doi.org/10.1016/j.vph.2017.05.005</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Bloomer R.J., Goldfarb A.H., Wideman L., McKenzie M.J., Consitt L.A. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J. Strength Cond. Res. 2005;19(2):276–285. https://doi.org/10.1519/14823.1</mixed-citation><mixed-citation xml:lang="en">Bloomer R.J., Goldfarb A.H., Wideman L., McKenzie M.J., Consitt L.A. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J. Strength Cond. Res. 2005;19(2):276–285. https://doi.org/10.1519/14823.1</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Kalogeris T., Baines C.P., Krenz M., Korthuis R.J. Cell biology of ischemia/reperfusion injury. Int. Rev. Cell Mol. Biol. 2012;298:229– 317. https://doi.org/10.1016/B978-0-12-394309-5.00006-7</mixed-citation><mixed-citation xml:lang="en">Kalogeris T., Baines C.P., Krenz M., Korthuis R.J. Cell biology of ischemia/reperfusion injury. Int. Rev. Cell Mol. Biol. 2012;298:229–317. https://doi.org/10.1016/B978-0-12-3943095.00006-7</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Olver T.D., Ferguson B.S., Laughlin M.H. Molecular mechanisms for exercise training-induced changes in vascular structure and function: skeletal muscle, cardiac muscle, and the brain. Prog. Mol. Biol. Transl. Sci. 2015;135:227–257. https://doi.org/10.1016/bs.pmbts.2015.07.017</mixed-citation><mixed-citation xml:lang="en">Olver T.D., Ferguson B.S., Laughlin M.H. Molecular mechanisms for exercise training-induced changes in vascular structure and function: skeletal muscle, cardiac muscle, and the brain. Prog. Mol. Biol. Transl. Sci. 2015;135:227–257. https://doi.org/10.1016/bs.pmbts.2015.07.017</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Calvert J.W., Condit M.E., Aragon J.P., Nicholson C.K., Moody B.F., Hood R.L., et al. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of beta(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circ. Res. 2011;108(12):1448–1458. https://doi.org/10.1161/CIRCRESAHA.111.241117</mixed-citation><mixed-citation xml:lang="en">Calvert J.W., Condit M.E., Aragon J.P., Nicholson C.K., Moody B.F., Hood R.L., et al. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of beta(3)-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circ. Res. 2011;108(12):1448–1458. https://doi.org/10.1161/CIRCRESAHA.111.241117</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Verhaar M.C., Westerweel P.E., van Zonneveld A.J., Rabelink T.J. Free radical production by dysfunctional eNOS. Heart. 2004;90(5):494–495. https://doi.org/10.1136/hrt.2003.029405</mixed-citation><mixed-citation xml:lang="en">Verhaar M.C., Westerweel P.E., van Zonneveld A.J., Rabelink T.J. Free radical production by dysfunctional eNOS. Heart. 2004;90(5):494–495. https://doi.org/10.1136/hrt.2003.029405</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Prior B.M., Yang H.T., Terjung R.L. What makes vessels grow with exercise training? J. Appl. Physiol. 2004;97(3):1119–1128. https://doi.org/10.1152/japplphysiol.00035.2004</mixed-citation><mixed-citation xml:lang="en">Prior B.M., Yang H.T., Terjung R.L. What makes vessels grow with exercise training? J. Appl. Physiol. 2004;97(3):1119–1128. https://doi.org/10.1152/japplphysiol.00035.2004</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Hoier B., Hellsten Y. Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF. Microcirculation. 2014 ;21(4):301–314. https://doi.org/10.1111/micc.12117</mixed-citation><mixed-citation xml:lang="en">Hoier B., Hellsten Y. Exercise-induced capillary growth in human skeletal muscle and the dynamics of VEGF. Microcirculation. 2014 ;21(4):301–314. https://doi.org/10.1111/micc.12117</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Cai D., Yuan M., Frantz D.F., Melendez P.A., Hansen L., Lee J., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005;11(2):183–190. https://doi.org/10.1038/nm1166</mixed-citation><mixed-citation xml:lang="en">Cai D., Yuan M., Frantz D.F., Melendez P.A., Hansen L., Lee J., et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat. Med. 2005;11(2):183–190. https://doi.org/10.1038/nm1166</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Rogero M.M., Calder P.C. Obesity, inflammation, toll-like receptor 4 and fatty acids. Nutrients. 2018;10(4):e432. https://doi.org/10.3390/nu10040432</mixed-citation><mixed-citation xml:lang="en">Rogero M.M., Calder P.C. Obesity, inflammation, toll-like receptor 4 and fatty acids. Nutrients. 2018;10(4):e432. https://doi.org/10.3390/nu10040432</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Liu H.W., Chang S.J. Moderate exercise suppresses NFkappaB signaling and activates the SIRT1-AMPK-PGC1alpha axis to attenuate muscle loss in diabetic db/db Mice. Front. Physiol. 2018;9:636. https://doi.org/10.3389/fphys.2018.00636</mixed-citation><mixed-citation xml:lang="en">Liu H.W., Chang S.J. Moderate exercise suppresses NFkappaB signaling and activates the SIRT1-AMPK-PGC1alpha axis to attenuate muscle loss in diabetic db/db Mice. Front. Physiol. 2018;9:636. https://doi.org/10.3389/fphys.2018.00636</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lancaster G.I., Febbraio M.A. The immunomodulating role of exercise in metabolic disease. Trends Immunol. 2014;35(6):262–269. https://doi.org/10.1016/j.it.2014.02.008</mixed-citation><mixed-citation xml:lang="en">Lancaster G.I., Febbraio M.A. The immunomodulating role of exercise in metabolic disease. Trends Immunol. 2014;35(6):262–269. https://doi.org/10.1016/j.it.2014.02.008</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Creber R.M.M., Lee C.S., Margulies K., Ellis S., Riegel B. Exercise in heart failure and patterns of inflammation and myocardial stress over time. Circulation. 2014;130(2):A11902</mixed-citation><mixed-citation xml:lang="en">Creber R.M.M., Lee C.S., Margulies K., Ellis S., Riegel B. Exercise in heart failure and patterns of inflammation and myocardial stress over time. Circulation. 2014;130(2):A11902</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffmann C., Weigert C. Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptathions. Cold Spring Harb. Perspect. Med. 2017;7(11):a029793. https://doi.org/10.1101/cshperspect.a029793</mixed-citation><mixed-citation xml:lang="en">Hoffmann C., Weigert C. Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptathions. Cold Spring Harb. Perspect. Med. 2017;7(11):a029793. https://doi.org/10.1101/cshperspect.a029793</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Schnyder S., Handschin C. Skeletal muscle as an endocrine organ: PGC-1alpha, myokines and exercise. Bone. 2015;80:115–125. https://doi.org/10.1016/j.bone.2015.02.008</mixed-citation><mixed-citation xml:lang="en">Schnyder S., Handschin C. Skeletal muscle as an endocrine organ: PGC-1alpha, myokines and exercise. Bone. 2015;80:115–125. https://doi.org/10.1016/j.bone.2015.02.008</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012;8(8):457–465. https://doi.org/10.1038/nrendo.2012.49</mixed-citation><mixed-citation xml:lang="en">Pedersen B.K., Febbraio M.A. Muscles, exercise and obesity: skeletal muscle as a secretory organ. Nat. Rev. Endocrinol. 2012;8(8):457–465. https://doi.org/10.1038/nrendo.2012.49</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Mathur N., Pedersen B.K. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm. 2008;2008:109502. https://doi.org/10.1155/2008/109502</mixed-citation><mixed-citation xml:lang="en">Mathur N., Pedersen B.K. Exercise as a mean to control low-grade systemic inflammation. Mediators Inflamm. 2008;2008:109502. https://doi.org/10.1155/2008/109502</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Ellingsgaard H., Hauselmann I., Schuler B., Habib A.M., Baggio L.L., Meier D.T., et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011;17(11):1481–1489. https://doi.org/10.1038/nm.2513</mixed-citation><mixed-citation xml:lang="en">Ellingsgaard H., Hauselmann I., Schuler B., Habib A.M., Baggio L.L., Meier D.T., et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat. Med. 2011;17(11):1481–1489. https://doi.org/10.1038/nm.2513</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Keller C., Hellsten Y., Steensberg A., Pedersen B.K. Differential regulation of IL-6 and TNF-alpha via calcineurin in human skeletal muscle cells. Cytokine. 2006;36(3-4):141–147. https://doi.org/10.1016/j.cyto.2006.10.014</mixed-citation><mixed-citation xml:lang="en">Keller C., Hellsten Y., Steensberg A., Pedersen B.K. Differential regulation of IL-6 and TNF-alpha via calcineurin in human skeletal muscle cells. Cytokine. 2006;36(3-4):141–147. https://doi.org/10.1016/j.cyto.2006.10.014</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Seldin M.M., Peterson J.M., Byerly M.S., Wei Z., Wong G.W. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J. Biol. Chem. 2012;287(15):11968– 11980. https://doi.org/10.1074/jbc.M111.336834</mixed-citation><mixed-citation xml:lang="en">Seldin M.M., Peterson J.M., Byerly M.S., Wei Z., Wong G.W. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J. Biol. Chem. 2012;287(15):11968– 11980. https://doi.org/10.1074/jbc.M111.336834</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Oshima Y., Ouchi N., Sato K., Izumiya Y., Pimentel D.R., Walsh K. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation. 2008;117(24):3099– 3108. https://doi.org/10.1161/CIRCULATIONAHA.108.767673</mixed-citation><mixed-citation xml:lang="en">Oshima Y., Ouchi N., Sato K., Izumiya Y., Pimentel D.R., Walsh K. Follistatin-like 1 is an Akt-regulated cardioprotective factor that is secreted by the heart. Circulation. 2008;117(24):3099–3108. https://doi.org/10.1161/CIRCULATIONAHA.108.767673</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Xi Y., Gong D.W., Tian Z.J. FSTL1 as a Potential mediator of exercise-induced cardioprotection in post-myocardial infarction rats. Sci. Rep. 2016;6:32424. https://doi.org/10.1038/srep32424</mixed-citation><mixed-citation xml:lang="en">Xi Y., Gong D.W., Tian Z.J. FSTL1 as a Potential mediator of exercise-induced cardioprotection in post-myocardial infarction rats. Sci. Rep. 2016;6:32424. https://doi.org/10.1038/srep32424</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Kuang X.L., Zhao X.M., Xu H.F., Shi Y.Y., Deng J.B., Sun G.T. Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development. BMC Neurosci. 2010;11:137. https://doi.org/10.1186/1471-2202-11-137</mixed-citation><mixed-citation xml:lang="en">Kuang X.L., Zhao X.M., Xu H.F., Shi Y.Y., Deng J.B., Sun G.T. Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development. BMC Neurosci. 2010;11:137. https://doi.org/10.1186/14712202-11-137</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Matthews V.B., Astrom M.B., Chan M.H.S., Bruce C.R., Krabbe K.S., Prelovsek O., et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia. 2009);52(7):1409–1418. https://doi.org/10.1007/s00125-009-1364-1</mixed-citation><mixed-citation xml:lang="en">Matthews V.B., Astrom M.B., Chan M.H.S., Bruce C.R., Krabbe K.S., Prelovsek O., et al. Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase. Diabetologia. 2009);52(7):1409–1418. https://doi.org/10.1007/s00125-009-1364-1</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Anderson L., Thompson D.R., Oldridge N., Zwisler A.D., Rees K., Martin N., et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst. Rev. 2016;(1):CD001800. https://doi.org/10.1002/14651858.CD001800.pub3</mixed-citation><mixed-citation xml:lang="en">Anderson L., Thompson D.R., Oldridge N., Zwisler A.D., Rees K., Martin N., et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst. Rev. 2016;(1):CD001800. https://doi.org/10.1002/14651858.CD001800.pub3</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
