smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICON10.47529/2223-2524.2024.1.7smjournal-446Research ArticleСПОРТИВНОЕ ПИТАНИЕSPORTS SUPPLEMENTSВлияние некоторых компонентов специализированных продуктов для спортсменов на кишечный микробиом и связанные с ним показатели макроорганизмаInfluence of some components of specialized products for athletes on the intestinal microbiome and related macroorganism indicatorshttps://orcid.org/0000-0002-1237-5147КобельковаИ. В.KobelkovaI. V.

Кобелькова Ирина Витальевна, к.м.н., в.н.с. лаборатории спортивной антропологии и нутрициологии; доцент 

109240, Москва, Устьинский пр., 2/14

125371, Москва, Волоколамское ш., 91

Irina V. Kobelkova, Cand. Sci. (Med.), Senior Researcher of Sports Anthropology and Nutrition Laboratory; Associate Professor

109240, Moscow, Ustinsky Ave., 2/14

125371, Moscow, Volokolamskoe highway, 91

irinavit66@mail.ruhttps://orcid.org/0000-0002-2279-648XКоростелеваМ. М.KorostelevaM. M.

Коростелева Маргарита Михайловна, к.м.н., с.н.с. лаборатории спортивной антропологии и нутрициологии; доцент кафедры управления сестринской деятельностью

109240, Москва, Устьинский пр., 2/14

117198, Москва, ул. Миклухо-Маклая, 6

Margarita M. Korosteleva, Cand. Sci. (Med.), Senior Researcher of Sports Anthropology and Nutrition Laboratory; Associate Professor of the Department of Management of Nursing Activities

109240, Moscow, Ustinsky Ave., 2/14

117198, Moscow, Miklouho-Maklaya str., 6

korostel@bk.ruФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»; Академия постдипломного образования ФГБУ «Федеральный научно-клинический центр» ФМБАРоссияFederal Research Center for Nutrition, Biotechnology and Food Safety; Academy of Postgraduate Education of Scientific and Clinical Center of the Federal Medical and Biological AgencyRussian FederationФГБУН «Федеральный исследовательский центр питания, биотехнологии и безопасности пищи»; ФГАОУ ВО «Российский университет дружбы народов»РоссияFederal Research Center for Nutrition, Biotechnology and Food Safety; Peoples’ Friendship University of RussiaRussian Federation2024010220241416579Copyright © Кобелькова И.В., Коростелева М.М., 20242024Кобелькова И.В., Коростелева М.М.Kobelkova I.V., Korosteleva M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/446

Цель: анализ данных литературы о влиянии некоторых компонентов специализированных пищевых продуктов для спортсменов на качественный и количественный состав кишечного микробиома и связанные с ним показатели макроорганизма.Материалы и методы: поиск в крупнейших базах данных статей на английском и русском языках без ограничения глубины поиска по времени с использованием ключевых слов «специализированные пищевые продукты», «биологически активные вещества», «спортсмены», «питание», «микробиом», «микробиота», «supplements», «microbiota», «microbiome» «athletes», «nutrition».Результаты: показано, что нормализация рациона, а следовательно, и пищевого статуса, дефицитного по некоторым макро- и микроэлементам, витаминам и антиоксидантам, возможна не только с использованием биологически активных добавок, содержащих эти и другие вещества, но и за счет потребления про- и пребиотиков, модулирующих и создающих благоприятные условия для поддержания оптимального состава кишечной микробиоты и эндогенного синтеза различных биологически активных веществ. Установлено участие микрофлоры в поддержании функциональной активности желудочно-кишечного тракта, обеспечении адекватного иммунного ответа, поддержании кислотно-щелочного баланса и водно-солевого обмена, синтезе ряда биологически активных веществ.Заключение: оптимизация рационов питания спортсменов с использованием специализированной пищевой продукции, оказывающей модулирующее действие на микрофлору, занимает важное место в поддержании здоровья и работоспособности. При этом в большинстве проведенных исследований участвовали животные и требуется проведение исследований с участием больших выборок физически активных добровольцев и спортсменов разного уровня.

Purpose: to analyze literature data on the influence of some components of specialized food products for athletes on the qualitative and quantitative composition of the intestinal microbiome and related indicators of the macroorganism.Materials and methods: The selection of current scientific articles was carried out in open electronic databases: Web of Science, Scopus, PubMed. ncbi, Scientific Electronic Library of the Russian Federation (elibrary.ru), Russian State Library and others. The search depth is not limited.Results. It has been shown that normalization of the diet, and therefore the nutritional status, deficient in some macro- (calcium, magnesium), microelements (iron, zinc), vitamins (A, B1, B2, B6, folates, B12, D), antioxidants, is possible not only with the help of dietary supplements containing these and other (L-carnitine, caffeine) substances, but to a significant extent this improvement is possible through the consumption of pro- and prebiotics, modulating and creating favorable conditions for maintaining the optimal composition of the intestinal microbiota and endogenous synthesis of various biologically active substances. The participation of microflora in maintaining the integrity of the functional activity of the gastrointestinal tract, ensuring an adequate immune response, maintaining acid-base balance and water-salt metabolism, and the synthesis of a number of biologically active substances has been established. Most studies have been conducted on animals.Conclusion: optimization of athletes’ diets using specialized food products that have a modulating effect on microflora plays an important role in maintaining health and performance. The issue requires further study with the participation of volunteers.

специализированные пищевые продуктыбиологически активные добавкипитаниемикробиомспортсменыspecialized food productsdietary supplementsnutritionmicrobiomeathletesReferencesKerksick C.M., Wilborn C.D., Roberts M.D., Smith-Ryan A., Kleiner S.M., Jäger R., Collins R., Cooke M., Davis J.N., Galvan E., Greenwood M., Lowery L.M., Wildman R., Antonio J., Kreider R.B. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018 Aug 1;15(1):38. https://doi.org/10.1186/s12970-018-0242-y.Kerksick C.M., Wilborn C.D., Roberts M.D., Smith-Ryan A., Kleiner S.M., Jäger R., Collins R., Cooke M., Davis J.N., Galvan E., Greenwood M., Lowery L.M., Wildman R., Antonio J., Kreider R.B. ISSN exercise & sports nutrition review update: research & recommendations. J Int Soc Sports Nutr. 2018 Aug 1;15(1):38. https://doi.org/10.1186/s12970-018-0242-y.Кобелькова И.В., Коростелева М.М. Влияние основных пищевых веществ на состав кишечного микробиома и адаптационного потенциала спортсмена. Наука и спорт: современные тенденции. 2022. Т. 10. № 2. С. 15-26. https://doi.org/10.36028/2308-8826-2022-10-2-15-26Kobelkova I.V., Korosteleva M.M. The influence of basic nutrients on the composition of the intestinal microbiome and optimization of the adaptive potential of an athlete. Science and sport: modern trends. 2022. T. 10. No. 2. P. 15-26 https://doi.org/10.36028/2308-8826-2022-10-2-15-26Кобелькова И.В., Коростелева М.М., Мавлиев Ф.А., Набатов А.А., Назаренко А.С., Никитюк Д.Б. Введение специализированных пищевых продуктов в рацион спортсменов сборной РФ по академической гребле. Наука и спорт: современные тенденции. 2022. Т. 10. № 4. С. 6–15. https://doi.org/10.36028/2308-8826-2022-10-4-6-15Kobelkova I.V., Korosteleva M.M., Mavliev F.A., Nabatov A.A., Nazarenko A.S., Nikityuk D.B. Introduction of specialized food products into the diet of athletes of the Russian national rowing team. Science and sport: modern trends. 2022. T. 10. No. 4. P. 6–15. https://doi.org/10.36028/2308-8826-2022-10-4-6-15Maughan R.J., Burke L.M., Dvorak J., Larson-Meyer D.E., Peeling P., Phillips S.M., Rawson E.S., Walsh N.P., Garthe I., Geyer H., Meeusen R., van Loon L.J.C., Shirreffs S.M., Spriet L.L., Stuart M., Vernec A., Currell K., Ali V.M., Budgett R.G., Ljungqvist A., Mountjoy M., Pitsiladis Y.P., Soligard T., Erdener U., Engebretsen L. IOC consensus statement: dietary supplements and the high-performance athlete. Br J Sports Med. 2018 Apr;52(7):439-455. https://doi.org/10.1136/bjsports-2018-099027.Maughan R.J., Burke L.M., Dvorak J., Larson-Meyer D.E., Peeling P., Phillips S.M., Rawson E.S., Walsh N.P., Garthe I., Geyer H., Meeusen R., van Loon L.J.C., Shirreffs S.M., Spriet L.L., Stuart M., Vernec A., Currell K., Ali V.M., Budgett R.G., Ljungqvist A., Mountjoy M., Pitsiladis Y.P., Soligard T., Erdener U., Engebretsen L. IOC consensus statement: dietary supplements and the high-performance athlete. Br J Sports Med. 2018 Apr;52(7):439-455. https://doi.org/10.1136/bjsports-2018-099027.Методические рекомендации MP 2.3.1.0253-21 «Нормы физиологических потребностей в энергии и пищевых веществах для различных групп населения Российской Федерации» (утв. Федеральной службой по надзору в сфере защиты прав потребителей и благополучия человека 22 июля 2021 г.)Methodological recommendations MP 2.3.1.0253-21 “Norms for physiological needs for energy and nutrients for various groups of the population of the Russian Federation” (approved by the Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being on July 22, 2021)Donati Zeppa S., Agostini D., Gervasi M., Annibalini G., Amatori S., Ferrini F., Sisti D., Piccoli G., Barbieri E., Sestili P., Stocchi V. Mutual Interactions among Exercise, Sport Supplements and Microbiota. Nutrients. 2019 Dec 20;12(1):17. https://doi.org/10.3390/nu12010017.Donati Zeppa S., Agostini D., Gervasi M., Annibalini G., Amatori S., Ferrini F., Sisti D., Piccoli G., Barbieri E., Sestili P., Stocchi V. Mutual Interactions among Exercise, Sport Supplements and Microbiota. Nutrients. 2019 Dec 20;12(1):17. https://doi.org/10.3390/nu12010017.Roberts J.D., Suckling C.A., Peedle G.Y., Murphy J.A., Dawkins T.G., Roberts M.G. An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention. Nutrients. 2016 Nov 17;8(11):733. https://doi.org/10.3390/nu8110733Roberts J.D., Suckling C.A., Peedle G.Y., Murphy J.A., Dawkins T.G., Roberts M.G. An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention. Nutrients. 2016 Nov 17;8(11):733. https://doi.org/10.3390/nu8110733Jacouton E., Mach N., Cadiou J., Lapaque N., Clement K., Dore J., van Hylckama Vlieg J.E., Smokvina T., Blottiere H.M. Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice. PLoS ONE. 2015;10:e0138880. https://doi.org/10.1371/journal.pone.0138880Jacouton E., Mach N., Cadiou J., Lapaque N., Clement K., Dore J., van Hylckama Vlieg J.E., Smokvina T., Blottiere H.M. Lactobacillus rhamnosus CNCMI-4317 Modulates Fiaf/Angptl4 in Intestinal Epithelial Cells and Circulating Level in Mice. PLoS ONE. 2015;10:e0138880. https://doi.org/10.1371/journal.pone.0138880Chen Y.M., Wei L., Chiu Y.S., Hsu Y.J., Tsai T.Y., Wang M.F., Huang C.C. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice. Nutrients. 2016;8:205. https://doi.org/10.3390/nu8040205Chen Y.M., Wei L., Chiu Y.S., Hsu Y.J., Tsai T.Y., Wang M.F., Huang C.C. Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice. Nutrients. 2016;8:205. https://doi.org/10.3390/nu8040205Huang W.C., Hsu Y.J., Li H., Kan N.W., Chen Y.M., Lin J.S., Hsu T.K., Tsai T.Y., Chiu Y.S., Huang C.C. Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans. Chin. J. Physiol. 2018;61:163–170. https://doi.org/10.4077/CJP.2018.BAH587Huang W.C., Hsu Y.J., Li H., Kan N.W., Chen Y.M., Lin J.S., Hsu T.K., Tsai T.Y., Chiu Y.S., Huang C.C. Effect of Lactobacillus Plantarum TWK10 on Improving Endurance Performance in Humans. Chin. J. Physiol. 2018;61:163–170. https://doi.org/10.4077/CJP.2018.BAH587Soares A.D.N., Wanner S.P., Morais E.S.S., Hudson A.S.R., Martins F.S., Cardoso V.N. Supplementation with Saccharomyces boulardii Increases the Maximal Oxygen Consumption and Maximal Aerobic Speed Attained by Rats Subjected to an Incremental-Speed Exercise. Nutrients.2019;11:2352. doi:10.3390/nu11102352Soares A.D.N., Wanner S.P., Morais E.S.S., Hudson A.S.R., Martins F.S., Cardoso V.N. Supplementation with Saccharomyces boulardii Increases the Maximal Oxygen Consumption and Maximal Aerobic Speed Attained by Rats Subjected to an Incremental-Speed Exercise. Nutrients.2019;11:2352. doi:10.3390/nu11102352Rao A.V., Bested A.C., Beaulne T.M., Katzman M.A., Iorio C., Berardi J.M., Logan A.C. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009;1:6. https://doi.org/10.1186/1757-4749-1-6Rao A.V., Bested A.C., Beaulne T.M., Katzman M.A., Iorio C., Berardi J.M., Logan A.C. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog. 2009;1:6. https://doi.org/10.1186/1757-4749-1-6West N.P., Pyne D.B., Cripps A.W., Hopkins W.G., Eskesen D.C., Jairath A., Christophersen C.T., Conlon M.A., Fricker P.A. Lactobacillus fermentum (PCC(R)) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes. Nutr J. 2011;10:30. https://doi.org/10.1186/1475-2891-10-30West N.P., Pyne D.B., Cripps A.W., Hopkins W.G., Eskesen D.C., Jairath A., Christophersen C.T., Conlon M.A., Fricker P.A. Lactobacillus fermentum (PCC(R)) supplementation and gastrointestinal and respiratory-tract illness symptoms: a randomised control trial in athletes. Nutr J. 2011;10:30. https://doi.org/10.1186/1475-2891-10-30Michalickova D., Minic R., Dikic N., Andjelkovic M., Kostic-Vucicevic M., Stojmenovic T., Nikolic I., Djordjevic B. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. Appl Physiol Nutr Metab. 2016;41:782–789. https://doi.org/10.1139/apnm-2015-0541Michalickova D., Minic R., Dikic N., Andjelkovic M., Kostic-Vucicevic M., Stojmenovic T., Nikolic I., Djordjevic B. Lactobacillus helveticus Lafti L10 supplementation reduces respiratory infection duration in a cohort of elite athletes: a randomized, double-blind, placebo-controlled trial. Appl Physiol Nutr Metab. 2016;41:782–789. https://doi.org/10.1139/apnm-2015-0541Strozzi G.P., Mogna L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S179-84. https://doi.org/10.1097/MCG.0b013e31818087d8Strozzi G.P., Mogna L. Quantification of folic acid in human feces after administration of Bifidobacterium probiotic strains. J Clin Gastroenterol. 2008 Sep;42 Suppl 3 Pt 2:S179-84. https://doi.org/10.1097/MCG.0b013e31818087d8Solopova A., Bottacini F., Venturi Degli Esposti E., Amaretti A., Raimondi S., Rossi M., van Sinderen D. Riboflavin Biosynthesis and Overproduction by a Derivative of the Human Gut Commensal Bifidobacterium longum subsp. infantis ATCC 15697. Front Microbiol. 2020 Sep 15;11:573335. https://doi.org/10.3389/fmicb.2020.573335.Solopova A., Bottacini F., Venturi Degli Esposti E., Amaretti A., Raimondi S., Rossi M., van Sinderen D. Riboflavin Biosynthesis and Overproduction by a Derivative of the Human Gut Commensal Bifidobacterium longum subsp. infantis ATCC 15697. Front Microbiol. 2020 Sep 15;11:573335. https://doi.org/10.3389/fmicb.2020.573335.Bashir M., Prietl B., Tauschmann M., Mautner S.I., Kump P.K., Treiber G., Wurm P., Gorkiewicz G., Hogenauer C., Pieber T.R. Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. Eur. J. Nutr. 2016;55:1479–1489. https://doi.org/10.1007/s00394-015-0966-2Bashir M., Prietl B., Tauschmann M., Mautner S.I., Kump P.K., Treiber G., Wurm P., Gorkiewicz G., Hogenauer C., Pieber T.R. Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract. Eur. J. Nutr. 2016;55:1479–1489. https://doi.org/10.1007/s00394-015-0966-2Choi Y., Lee S., Kim S., Lee J., Ha J., Oh H., Lee Y., Kim Y., Yoon Y. Vitamin E (α-tocopherol) consumption influences gut microbiota composition. Int J Food Sci Nutr. 2020 Mar;71(2):221-225. https://doi.org/10.1080/09637486.2019.1639637Choi Y., Lee S., Kim S., Lee J., Ha J., Oh H., Lee Y., Kim Y., Yoon Y. Vitamin E (α-tocopherol) consumption influences gut microbiota composition. Int J Food Sci Nutr. 2020 Mar;71(2):221-225. https://doi.org/10.1080/09637486.2019.1639637Xuan Zhu, Shasha Xiang, Xiao Feng, Huanhuan Wang, Shiyi Tian, Yuanyuan Xu, Lihua Shi, Lu Yang, Mian Li, Yubiao Shen, Jie Chen, Yuewen Chen, and Jianzhong Han. Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition Journal of Agricultural and Food Chemistry 2019 67 (3), 916-926 Https://doi.org/10.1021/acs.jafc.8b05730RudzkiXuan Zhu, Shasha Xiang, Xiao Feng, Huanhuan Wang, Shiyi Tian, Yuanyuan Xu, Lihua Shi, Lu Yang, Mian Li, Yubiao Shen, Jie Chen, Yuewen Chen, and Jianzhong Han. Impact of Cyanocobalamin and Methylcobalamin on Inflammatory Bowel Disease and the Intestinal Microbiota Composition Journal of Agricultural and Food Chemistry 2019 67 (3), 916-926 Https://doi.org/10.1021/acs.jafc.8b05730RudzkiDitscheid B., Keller S. & Jahreis G. Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. Eur J Nutr (2009) 48, 22–30.Ditscheid B., Keller S. & Jahreis G. Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences. Eur J Nutr (2009) 48, 22–30.Starke I.C., Pieper, R. Neumann K., et al. The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets. FEMS Microbiol. Ecol. 2014. 87:416–427.Starke I.C., Pieper, R. Neumann K., et al. The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets. FEMS Microbiol. Ecol. 2014. 87:416–427.Murakami S., Goto Y., Ito K., Hayasaka S., Kurihara S., Soga T., Tomita M., Fukuda S. The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control. Evid. Based Complement. Altern. Med. 2015;2015:824395. https://doi.org/10.1155/2015/824395Murakami S., Goto Y., Ito K., Hayasaka S., Kurihara S., Soga T., Tomita M., Fukuda S. The Consumption of Bicarbonate-Rich Mineral Water Improves Glycemic Control. Evid. Based Complement. Altern. Med. 2015;2015:824395. https://doi.org/10.1155/2015/824395Watson H., Mitra S., Croden F.C., Taylor M., Wood H.M., Perry S.L., Spencer J.A., Quirke P., Toogood G.J., Lawton C.L., et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67:1974–1983. https://doi.org/10.1136/gutjnl-2017-314968Watson H., Mitra S., Croden F.C., Taylor M., Wood H.M., Perry S.L., Spencer J.A., Quirke P., Toogood G.J., Lawton C.L., et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67:1974–1983. https://doi.org/10.1136/gutjnl-2017-314968Etxeb erria U., Arias N., Boque N., Macarulla M.T., Portillo M.P., Martinez J.A., Milagro F.I. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. J. Nutr. Biochem. 2015;26:651–660. https://doi.org/10.1016/j.jnutbio.2015.01.002Etxeb erria U., Arias N., Boque N., Macarulla M.T., Portillo M.P., Martinez J.A., Milagro F.I. Reshaping faecal gut microbiota composition by the intake of trans-resveratrol and quercetin in high-fat sucrose diet-fed rats. J. Nutr. Biochem. 2015;26:651–660. https://doi.org/10.1016/j.jnutbio.2015.01.002Anhe F.F., Roy D., Pilon G., Dudonne S., Matamoros S., Varin T.V., Garofalo C., Moine Q., Desjardins Y., Levy E., et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2015;64:872–883. https://doi.org/10.1136/gutjnl-2014-307142Anhe F.F., Roy D., Pilon G., Dudonne S., Matamoros S., Varin T.V., Garofalo C., Moine Q., Desjardins Y., Levy E., et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut. 2015;64:872–883. https://doi.org/10.1136/gutjnl-2014-307142Li Z., Henning S.M., Lee R.P., Lu Q.Y., Summanen P.H., Thames G., Corbett K., Downes J., Tseng C.H., Finegold S.M., et al. Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct. 2015;6:2487–2495. https://doi.org/10.1039/C5FO00669DLi Z., Henning S.M., Lee R.P., Lu Q.Y., Summanen P.H., Thames G., Corbett K., Downes J., Tseng C.H., Finegold S.M., et al. Pomegranate extract induces ellagitannin metabolite formation and changes stool microbiota in healthy volunteers. Food Funct. 2015;6:2487–2495. https://doi.org/10.1039/C5FO00669DJaquet M., Rochat I., Moulin J., Cavin C., Bibiloni R. Impact of coffee consumption on the gut microbiota: A human volunteer study. Int. J. Food Microbiol. 2009;130:117–121. https://doi.org/10.1016/j.ijfoodmicro.2009.01.011.Jaquet M., Rochat I., Moulin J., Cavin C., Bibiloni R. Impact of coffee consumption on the gut microbiota: A human volunteer study. Int. J. Food Microbiol. 2009;130:117–121. https://doi.org/10.1016/j.ijfoodmicro.2009.01.011.Janssens P.L., Penders J., Hursel R., Budding A.E., Savelkoul P.H., Westerterp-Plantenga M.S. Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota. PLoS ONE. 2016;11:e0153134. https://doi.org/10.1371/journal.pone.0153134Janssens P.L., Penders J., Hursel R., Budding A.E., Savelkoul P.H., Westerterp-Plantenga M.S. Long-Term Green Tea Supplementation Does Not Change the Human Gut Microbiota. PLoS ONE. 2016;11:e0153134. https://doi.org/10.1371/journal.pone.0153134«Формуляр лекарственных средств, биологически активных добавок к пище и изделий медицинского назначения ФМБА России, используемых для медико-биологического обеспечения спортсменов спортивных сборных команд Российской Федерации» (1052-formulyar-2023 (sportfmba.ru))“Formulary of medicines, biologically active food additives and medical products of the FMBA of Russia, used for medical and biological support of athletes of sports teams of the Russian Federation” (1052-formulyar-2023 (sportfmba.ru)) (1052-formulyar-2023 (sportfmba.ru))Всемирный антидопинговый кодекс, 2021 https://www.wada-ama.org/sites/default/files/resources/files/2021_vsemirnyy_antidopingovyy_kodeks.pdfWorld Anti-Doping Code, 2021 https://www.wada-ama.org/sites/default/files/resources/files/2021_vsemirnyy_antidopingovyy_kodeks.pdfОфициальный сайт РУСАДА https://rusada.ru/substances/bad/Official website of RUSADA https://rusada.ru/substances/bad/Jäger R., Mohr A.E., Carpenter K.C., et al. International Society of Sports Nutrition Position Stand: Probiotics. J Int Soc Sports Nutr. 2019;16(1):62. doi:10.1186/s12970-019-0329-0Jäger R., Mohr A.E., Carpenter K.C., et al. International Society of Sports Nutrition Position Stand: Probiotics. J Int Soc Sports Nutr. 2019;16(1):62. doi:10.1186/s12970-019-0329-0Coqueiro A.Y., de Oliveira Garcia A.B., Rogero M.M., Tirapegui J. /Probiotic supplementation in sports and physical exercise: does it present any ergogenic effect? //Nutr Health. 2017. 23.: P. 239–249. https://doi.org/10.1177/0260106017721000Coqueiro A.Y., de Oliveira Garcia A.B., Rogero M.M., Tirapegui J. /Probiotic supplementation in sports and physical exercise: does it present any ergogenic effect? //Nutr Health. 2017. 23.: P. 239–249. https://doi.org/10.1177/0260106017721000Tuohy K.M., Probert H.M., Smejkal C.W., Gibson G.R. Using probiotics and prebiotics to improve gut health. Drug Discov Today. 2003 Aug 1;8(15):692–700. https://doi.org/10.1016/s1359-6446(03)02746-6.Tuohy K.M., Probert H.M., Smejkal C.W., Gibson G.R. Using probiotics and prebiotics to improve gut health. Drug Discov Today. 2003 Aug 1;8(15):692–700. https://doi.org/10.1016/s1359-6446(03)02746-6.LeBlanc J. G. Burgess C., Sesma F., de Giori G.S., & van Sinderen, DIngestion of milk fermented by genetically modified Lactococcus lactis improves the riboflavin status of deficient rats //Journal of dairy science. 2005;88(10):3435–3442.LeBlanc J. G. Burgess C., Sesma F., de Giori G.S., & van Sinderen, DIngestion of milk fermented by genetically modified Lactococcus lactis improves the riboflavin status of deficient rats //Journal of dairy science. 2005;88(10):3435–3442.Mach N., Clark A. Micronutrient Deficiencies and the Human Gut Microbiota. Trends Microbiol. 2017 Aug;25(8):607-610. https://doi.org/10.1016/j.tim.2017.06.004Mach N., Clark A. Micronutrient Deficiencies and the Human Gut Microbiota. Trends Microbiol. 2017 Aug;25(8):607-610. https://doi.org/10.1016/j.tim.2017.06.004Cha H.R., et al. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. Demonstrates how a single micronutrient, vitamin A, modulates host immune responses through its effects on the composition of the intestinal microbiota. J Immunol. 2010;184:6799–6806.Cha H.R., et al. Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid. Demonstrates how a single micronutrient, vitamin A, modulates host immune responses through its effects on the composition of the intestinal microbiota. J Immunol. 2010;184:6799–6806.Ivanov I.I., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139:485–498.Ivanov I.I., et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139:485–498.Gaboriau-Routhiau V., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009;31:677–689.Gaboriau-Routhiau V., et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009;31:677–689.Nicholas M. Fleischman, Debanu Das, Abhinav Kumar et al. Molecular characterization of novel pyridoxal-5′-phosphatedependent enzymes from the human microbiome /First published: 29 May 2014. https://doi.org/10.1002/pro.2493Nicholas M. Fleischman, Debanu Das, Abhinav Kumar et al. Molecular characterization of novel pyridoxal-5′-phosphatedependent enzymes from the human microbiome /First published: 29 May 2014. https://doi.org/10.1002/pro.2493Yamamoto E.A., Jørgensen T.N. Relationships between vitamin D, gut microbiome, and systemic autoimmunity. Frontiers in immunology. 2020:3141.Yamamoto E.A., Jørgensen T.N. Relationships between vitamin D, gut microbiome, and systemic autoimmunity. Frontiers in immunology. 2020:3141.Bosman E.S. Bosman E.S., Albert A.Y., Lui H., Dutz J.P., & Vallance B.A. Skin exposure to narrow band ultraviolet (UVB) light modulates the human intestinal microbiome //Frontiers in Microbiology. 2019:2410.Bosman E.S. Bosman E.S., Albert A.Y., Lui H., Dutz J.P., & Vallance B.A. Skin exposure to narrow band ultraviolet (UVB) light modulates the human intestinal microbiome //Frontiers in Microbiology. 2019:2410.Skrypnik K., Suliburska J. Association between the gut microbiota and mineral metabolism. J Sci Food Agric. 2018 May; 98(7):2449-2460. https://doi.org/10.1002/jsfa.8724Skrypnik K., Suliburska J. Association between the gut microbiota and mineral metabolism. J Sci Food Agric. 2018 May; 98(7):2449-2460. https://doi.org/10.1002/jsfa.8724Gomes J.M., Costa J.A., Alfenas R.C. Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity? Br J Nutr. 2015 Dec 14;114(11):1756–1765. https://doi.org/10.1017/S0007114515003608.Gomes J.M., Costa J.A., Alfenas R.C. Could the beneficial effects of dietary calcium on obesity and diabetes control be mediated by changes in intestinal microbiota and integrity? Br J Nutr. 2015 Dec 14;114(11):1756–1765. https://doi.org/10.1017/S0007114515003608.Weaver C.M. Diet, gut microbiome, and bone health. Curr Osteoporos Rep. 2015 Apr; 13(2):125-30. https://doi.org/10.1007/s11914-015-0257-0.Weaver C.M. Diet, gut microbiome, and bone health. Curr Osteoporos Rep. 2015 Apr; 13(2):125-30. https://doi.org/10.1007/s11914-015-0257-0.Hojberg O., Canibe N., Poulsen D., et al.Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned pigs. Appl. Environ. Microbiol. 2005. 71:2267-2277.Hojberg O., Canibe N., Poulsen D., et al.Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned pigs. Appl. Environ. Microbiol. 2005. 71:2267-2277.Reed S., Neuman H., Moscovich S., et al.2015. Chronic zinc deficiency alters chick gut microbiota composition and function. Nutrients7:9768-9784.Reed S., Neuman H., Moscovich S., et al.2015. Chronic zinc deficiency alters chick gut microbiota composition and function. Nutrients7:9768-9784.Schaible U.E., Kaufmann S.H. Iron and microbial infection. Nat Rev Microbiol. 2004;2:946–953.Schaible U.E., Kaufmann S.H. Iron and microbial infection. Nat Rev Microbiol. 2004;2:946–953.Reddy B.S., Pleasants J.R., Wostmann B.S. Effect of intestinal microflora on iron and zinc metabolism, and on activities of metalloenzymes in rats. J Nutr. 1972;102:101–107.Reddy B.S., Pleasants J.R., Wostmann B.S. Effect of intestinal microflora on iron and zinc metabolism, and on activities of metalloenzymes in rats. J Nutr. 1972;102:101–107.Werner T., et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut. 2011;60:325–333.Werner T., et al. Depletion of luminal iron alters the gut microbiota and prevents Crohn’s disease-like ileitis. Gut. 2011;60:325–333.Успенский Ю.П., Новикова В.П., Барышникова Н.В. Дефицит железа и кишечная микробиота//Медицина: теория и практика (2022), 7(2), 3–14. https://ojs3.gpmu.org/index.php/med-theory-and-practice/article/view/4148Uspensky Yu.P., Novikova V.P., & Baryshnikova N.V. (2022). Iron deficiency and intestinal microbiota//Medicine: theory and practice, 7(2), 3–14. t https://ojs3.gpmu.org/index.php/medtheory-and-practice/article/view/4148Fielding R., Riede L., Lugo J.P., Bellamine A. l-Carnitine Supplementation in Recovery after Exercise. Nutrients. 2018;10:349. https://doi.org/10.3390/nu10030349Fielding R., Riede L., Lugo J.P., Bellamine A. l-Carnitine Supplementation in Recovery after Exercise. Nutrients. 2018;10:349. https://doi.org/10.3390/nu10030349Koeth R.A., Lam-Galvez B.R., Kirsop J., Wang Z., Levison B.S., Gu X., Copeland M.F., Bartlett D., Cody D.B., Dai H.J., Culley M.K., Li X.S., Fu X., Wu Y., Li L., DiDonato J.A., Tang W.H.W, Garcia-Garcia J.C., Hazen S.L. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. J Clin Invest. 2019 Jan 2;129(1):373-387. https://doi.org/10.1172/JCI94601Koeth R.A., Lam-Galvez B.R., Kirsop J., Wang Z., Levison B.S., Gu X., Copeland M.F., Bartlett D., Cody D.B., Dai H.J., Culley M.K., Li X.S., Fu X., Wu Y., Li L., DiDonato J.A., Tang W.H.W, Garcia-Garcia J.C., Hazen S.L. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. J Clin Invest. 2019 Jan 2;129(1):373-387. https://doi.org/10.1172/JCI94601Coutinho-Wolino K.S., de F Cardozo L.F.M., de Oliveira Leal V., Mafra D., Stockler-Pinto M.B. Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far? Eur J Nutr. 2021 Oct;60(7):3567–3584. https://doi.org/10.1007/s00394-021-02491-6.Coutinho-Wolino K.S., de F Cardozo L.F.M., de Oliveira Leal V., Mafra D., Stockler-Pinto M.B. Can diet modulate trimethylamine N-oxide (TMAO) production? What do we know so far? Eur J Nutr. 2021 Oct;60(7):3567–3584. https://doi.org/10.1007/s00394-021-02491-6.González-Soltero R., Bailén M., de Lucas B., Ramírez-Goercke M.I., Pareja-Galeano H., Larrosa M. Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance. Nutrients. 2020 Nov 24;12(12):3611. https://doi.org/10.3390/nu12123611González-Soltero R., Bailén M., de Lucas B., Ramírez-Goercke M.I., Pareja-Galeano H., Larrosa M. Role of Oral and Gut Microbiota in Dietary Nitrate Metabolism and Its Impact on Sports Performance. Nutrients. 2020 Nov 24;12(12):3611. https:// doi.org/10.3390/nu12123611Guillochon M., Rowlands D.S. Solid, Gel, and Liquid Carbohydrate Format Effects on Gut Comfort and Performance. Int. J. Sport Nutr. Exerc. Metab. 2017;27:247–254. https://doi.org/10.1123/ijsnem.2016-0211Guillochon M., Rowlands D.S. Solid, Gel, and Liquid Carbohydrate Format Effects on Gut Comfort and Performance. Int. J. Sport Nutr. Exerc. Metab. 2017;27:247–254. https://doi.org/10.1123/ijsnem.2016-0211O’Brien W.J., Rowlands D.S. Fructose-maltodextrin ratio in a carbohydrate-electrolyte solution differentially affects exogenous carbohydrate oxidation rate, gut comfort, and performance. Am. J. Physiol. Gastrointest. Liver Physiol. 2011;300:G181–G189. https://doi.org/10.1152/ajpgi.00419.2010O’Brien W.J., Rowlands D.S. Fructose-maltodextrin ratio in a carbohydrate-electrolyte solution differentially affects exogenous carbohydrate oxidation rate, gut comfort, and performance. Am. J. Physiol. Gastrointest. Liver Physiol. 2011;300:G181–G189. https://doi.org/10.1152/ajpgi.00419.2010Clark A., Mach N. Exercise-induced stress behavior, gutmicrobiota-brain axis and diet: a systematic review for athletes. J Int Soc Sports Nutr. 2016 Nov 24;13:43. https://doi.org/10.1186/s12970-016-0155-6Clark A., Mach N. Exercise-induced stress behavior, gutmicrobiota-brain axis and diet: a systematic review for athletes. J Int Soc Sports Nutr. 2016 Nov 24;13:43. https://doi.org/10.1186/s12970-016-0155-6Burke L.M. Practical considerations for bicarbonate loading and sports performance. Nestle Nutr Inst Workshop Ser. 2013;75:15–26. https://doi.org/10.1159/000345814Burke L.M. Practical considerations for bicarbonate loading and sports performance. Nestle Nutr Inst Workshop Ser. 2013;75:15–26. https://doi.org/10.1159/000345814D’Angelo S. Polyphenols: Potential Beneficial Effects of These Phytochemicals in Athletes. Curr Sports Med Rep. 2020 Jul;19(7):260–265. https://doi.org/10.1249/JSR.0000000000000729.D’Angelo S. Polyphenols: Potential Beneficial Effects of These Phytochemicals in Athletes. Curr Sports Med Rep. 2020 Jul;19(7):260–265. https://doi.org/10.1249/JSR.0000000000000729.Ozdal T., Sela D.A., Xiao J., Boyacioglu D., Chen F., Capanoglu E. The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients. 2016;8:78. https://doi.org/10.3390/nu8020078Ozdal T., Sela D.A., Xiao J., Boyacioglu D., Chen F., Capanoglu E. The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility. Nutrients. 2016;8:78. https://doi.org/10.3390/nu8020078Ma G., Chen Y. Polyphenol supplementation benefits human health via gut microbiota: A systematic review via metaanalysis. J. Funct. Foods. 2020;66:103829. https://doi.org/10.1016/j.jff.2020.103829Ma G., Chen Y. Polyphenol supplementation benefits human health via gut microbiota: A systematic review via metaanalysis. J. Funct. Foods. 2020;66:103829. https://doi.org/10.1016/j.jff.2020.103829Sorrenti V., Fortinguerra S., Caudullo G., Buriani A. Deciphering the Role of Polyphenols in Sports Performance: From Nutritional Genomics to the Gut Microbiota toward Phytonutritional Epigenomics. Nutrients. 2020 Apr 29;12(5):1265. https://doi.org/10.3390/nu12051265Sorrenti V., Fortinguerra S., Caudullo G., Buriani A. Deciphering the Role of Polyphenols in Sports Performance: From Nutritional Genomics to the Gut Microbiota toward Phytonutritional Epigenomics. Nutrients. 2020 Apr 29;12(5):1265. https://doi.org/10.3390/nu12051265Wang P., Sang S. Metabolism and pharmacokinetics of resveratrol and pterostilbene. Biofactors. 2018;44:16–25. https://doi.org/10.1002/biof.1410Wang P., Sang S. Metabolism and pharmacokinetics of resveratrol and pterostilbene. Biofactors. 2018;44:16–25. https://doi.org/10.1002/biof.1410Chaplin A., Carpéné C., Mercader J. Resveratrol, Metabolic Syndrome, and Gut Microbiota. Nutrients. 2018 Nov 3;10(11):1651. https://doi.org/10.3390/nu10111651Chaplin A., Carpéné C., Mercader J. Resveratrol, Metabolic Syndrome, and Gut Microbiota. Nutrients. 2018 Nov 3;10(11):1651. https://doi.org/10.3390/nu10111651Hu Y., Chen D., Zheng P., Yu J., He J., Mao X., Yu B. The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy. Biomed Res Int. 2019 Apr 24;2019:5403761. https://doi.org/10.1155/2019/5403761Hu Y., Chen D., Zheng P., Yu J., He J., Mao X., Yu B. The Bidirectional Interactions between Resveratrol and Gut Microbiota: An Insight into Oxidative Stress and Inflammatory Bowel Disease Therapy. Biomed Res Int. 2019 Apr 24;2019:5403761. https://doi.org/10.1155/2019/5403761Close G.L., Hamilton D.L., Philp A., Burke L.M., Morton J.P. New strategies in sport nutrition to increase exercise performance. Free Radic. Biol. Med. 2016;98:144–158. https://doi.org/10.1016/j.freeradbiomed.2016.01.016Close G.L., Hamilton D.L., Philp A., Burke L.M., Morton J.P. New strategies in sport nutrition to increase exercise performance. Free Radic. Biol. Med. 2016;98:144–158. https://doi.org/10.1016/j.freeradbiomed.2016.01.016

The authors declare that there are no conflicts of interest present.