smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICON10.47529/2223-2524.2023.2.11smjournal-578Research ArticleСПОРТИВНОЕ ПИТАНИЕSPORTS SUPPLEMENTSСердечно-сосудистые эффекты анаболических андрогенных стероидов в пищевых добавкахCardiovascular Effects of Anabolic-Androgenic Steroids in Dietary Supplementsван дер БийлП.Van der BijlP.

Питер ван дер Бийл — Бакалавр стоматологической хирургии, доктор философии, почетный профессор и бывший заведующий кафедрой фармакологии  факультета медицины и медицинских наук

7505, Южная Африка, Кейптаун, Тайгерберг, Фрэнси ван Зейл Драйв 

Pieter van der Bijl — BChD, PhD, Emeritus Professor and Former Head Department of Pharmacology, Faculty of Medicine and Health Sciences

7505 South Africa, Cape Town, Tygerberg, Francie van Zijl Drive  

pietervanderbijlcpt@gmail.comван дер Бийл (мл.)П.Van der Bijl (Jr)P.

Питер ван дер Бийл (Мл.) — доктор философии, консультант-кардиолог, отделение эндоваскулярной терапии

7580, Южная Африка, Кейптаун, Куилс Ривер, дорога Ван Рибик, 33 

Pieter van der Bijl (Jr) — MD, PhD, Consultant Cardiologist, SA Endovascular, Netcare Kuils River Hospital

7580, South Africa, Cape Town, Kuils Rivier, van Riebeeck Rd, 33 

Стелленбошский университетЮжно-Африканская РеспубликаStellenbosch UniversitySouth AfricaБольница Куилс РиверЮжно-Африканская РеспубликаKuils River HospitalSouth Africa2023111120231327783Copyright © ван дер Бийл П., ван дер Бийл (мл.) П., 20232023ван дер Бийл П., ван дер Бийл (мл.) П.van der Bijl P., van der Bijl (Jr) P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/578

Пищевые добавки регулярно потребляются более чем 70 % населения США, а также участвующими в соревнованиях и не участвующими в соревнованиях спортсменами. Анаболические и андрогенные стероиды (ААС) часто встречаются в пищевых добавках и обладают потенциальной полиорганной токсичностью, в том числе значительным воздействием на сердечно-сосудистую систему. Сердечно-сосудистая токсичность ААС влияет на коронарные артерии, вызывая спазм, тромбоз и разрыв бляшки, приводящие к острым коронарным синдромам и инфарктам миокарда, а также прямую миокардиальную токсичность, вызывающую гипертрофию, фиброз и дисфункцию левого желудочка. Коронарные и миокардиальные эффекты в итоге вызывают сердечную недостаточность, опасные для жизни аритмии и внезапную сердечную смерть. Нерегулируемость ААС в пищевых добавках имеет множество последствий. И тренеры, и спортсмены должны знать, что положительный результат теста на запрещенное вещество (включая ААС) представляет собой потенциальное нарушение антидопинговых правил. Мы выступаем за улучшение информирования широкой общественности о возможности включения ААС в пищевые добавки, а также за его регулирование соответствующими органами.

Dietary supplements are regularly consumed by more than 70 % of the US population, as well as by competitive and non-competitive athletes. Anabolic-androgenic steroids (AAS) are frequently found in dietary supplements, and have the potential for multi-organ toxicity, including significant effects on the cardiovascular system. Cardiovascular toxicities of AAS include coronary artery effects, e.g. spasm, thrombosis and plaque rupture, leading to acute coronary syndromes and myocardial infarctions, as well as direct myocardial toxicity, causing left ventricular hypertrophy, fibrosis and dysfunction. Coronary and myocardial effects converge towards a common final pathway, causing heart failure, life-threatening arrhythmias and sudden cardiac death. The unregulated nature of AAS in dietary supplements has many ramifications. Both coaches and athletes should be aware that testing positive for a prohibited substance (including AAS) constitutes a potential doping violation. We advocate for improved education of the public at large regarding the potential for AAS to be included in dietary supplements, as well as its regulation by the appropriate authorities.

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The authors declare that there are no conflicts of interest present.