smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICON10.47529/2223-2524.2024.2.2smjournal-604Research ArticleЗАБОЛЕВАНИЯ СПОРТСМЕНОВSPORTS DISEASESКардиомиопатия такоцубо у спортсменовTakotsubo cardiomyopathy in athletesПетроваМ. В.PetrovaM. V.

Петрова Марина Владимировна, заведующая, кафедра анестезиологии и реанимации с курсом медицинской реабилитации Медицинского института

117198, Москва, улица Миклухо-Маклая, 6

Marina V. Petrova, Head of the Department, Department of Anesthesiology and Intensive Care with a Course of Medical Rehabilitation of Medical Institute

6 Miklukho-Maklaya str., Moscow, 117198

petrova-mv@rudn.ruСпасскийА. А.SpasskyA. A.

Спасский Андрей Александрович, профессор, кафедра анестезиологии и реанимации с курсом медицинской реабилитации Медицинского института РУДН; заместитель генерального директора по спортивной медицине Международного центра охраны здоровья

117198, Москва, улица Миклухо-Маклая, 6; Москва, ул. Октябрьская, 2

Andrey A. Spassky, Professor, Department of Anesthesiology and Intensive Care with a Course of Medical Rehabilitation of Medical Institute of Peoples’ Friendship University of Russia; Deputy Director General for Sports Medicine, International Center for Health Protection

6 Miklukho-Maklaya str., Moscow, 117198; 2 Oktyabrskaya str., Moscow

mailbox@rnmot.ruПоляевБ. А.PolyaevB. A.

Поляев Борис Александрович, заведующий, кафедра реабилитации, спортивной медицины и физической культуры ПФ; главный специалист Минздрава России по спортивной медицине

117513, Москва, ул. Островитянова, дом 1

Boris A. Polyaev, Head, Department of Rehabilitation, Sports Medicine and Physical Culture; Chief Specialist of the Ministry of Health of the Russian Federation in Sports Medicine

1 Ostrovityanova str., Moscow, 117513

polyaev@inbox.ruМихайловА. А.MihaylovA. A.

Михайлов Алексей Александрович, профессор, кафедра анестезиологии и реанимации с курсом медицинской реабилитации Медицинского института

117198, Москва, улица Миклухо-Маклая, 6

Alexey A. Mihaylov, Professor, Department of Anesthesiology and Intensive Care with a Course of Medical Rehabilitation of Medical Institute

117198, 6 Miklukho-Maklaya str., Moscow

amihaylov1960@yandex.ruФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»РоссияPatrice Lumumba Peoples’ Friendship Institute of RussiaRussian FederationФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»; Международный центр охраны здоровьяРоссияPatrice Lumumba Peoples’ Friendship Institute of Russia; International Center for Health ProtectionRussian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияPirogov Russian National Research Medical UniversityRussian Federation2024020820241426878Copyright © Петрова М.В., Спасский А.А., Поляев Б.А., Михайлов А.А., 20242024Петрова М.В., Спасский А.А., Поляев Б.А., Михайлов А.А.Petrova M.V., Spassky A.A., Polyaev B.A., Mihaylov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/604

Кардиомиопатия такоцубо (КТ) стала встречаться в клинической практике все чаще, причем при самой разной патологии, что, по-видимому, связано с улучшением диагностики данного заболевания. И вместе с тем до сих пор этот диагноз устанавливается не всегда, в первую очередь в связи с недостаточной осведомленностью врачей о данном заболевании. КТ имеет множество синонимов: разбитого сердца, стресс-индуцированная кардиомиопатия, синдром верхушечного баллонирования. КТ представляет собой форму острой, как правило, обратимой сердечной недостаточности, провоцируемой у большинства пациентов различными стрессорными факторами, протекающей с транзиторной дисфункцией преимущественно левого желудочка, клинически и эхокардиографически напоминающей острый коронарный синдром. В последнее время КТ довольно часто стала выявляться у спортсменов во время проведения нагрузочного тестирования (велоэргометрия, тредмил). Учитывая имеющийся большой объем информации по проблеме КТ и множество нерешенных вопросов, возникла необходимость проанализировать данные литературы и поделиться собственным опытом диагностики КТ. В статье освещаются аспекты этиологии, патогенеза, эпидемиологии, диагностики и лечения стресс-индуцированной КТ, возникающей в ответ на физический стресс и характеризующейся транзиторной дисфункцией левого желудочка. Клинический пример является собственным наблюдением авторов.

Takotsubo cardiomyopathy (TTC) has become more common in clinical practice, and with a wide variety of pathologies, which is apparently associated with an improvement in the diagnosis of this disease. At the same time, this diagnosis is still not always established, primarily due to the lack of doctors’ awareness about this disease. TTC has many synonyms: broken heart syndrome, stress-induced cardiomyopathy, apical ballooning syndrome. TTC is a form of acute and, as a rule, reversible heart failure, provoked in most patients by various stress factors, occurring with transient dysfunction primarily of the left ventricle, clinically and echocardiographically resembling acute coronary syndrome. Recently, TTC has become more common in athletes, during stress testing (bicycle ergometry, treadmill test). Taking into account the large amount of information about TTC and the many unresolved issues, it’s necessary to analyze the literature and share our own experience in TTC diagnosis. The article highlights aspects of the etiology, pathogenesis, epidemiology, diagnostics and treatment of stress-induced TTC, which occurs in response to physical or mental stress and characterized by transient left ventricular dysfunction. The clinical example is the authors’ own observation.

кардиомиопатия такоцубоострый коронарный синдромстресслевый желудочекэлектрокардиографияэхокардиографияспортtakotsubo cardiomyopathyacute coronary syndromestressleft ventricleelectrocardiographyechocardiographysportReferencesСтеклов В.И., Морозова Н.В., Иванов С.А. Гмир Т.Н. Гипертрофическая кардиомиопатия: диагностика, стратификация риска и стратегия профилактики внезапной сердечной смерти. Воен.-мед. журн. 2024;345(1):39–50.Steklov V.I., Morozova N.V., Ivanov S.A., Gmir T.N. Hypertrophic cardiomyopathy: diagnosis, risk stratification and strategies to prevent sudden cardiac death. Voenno-meditsinskii zhurnal = War and Medical Journal. 2024;345(1):39–50. (In Russ.).Maron B.J., Towbin J.A., Thiene G., Antzelevitch C., Corrado D., Arnett D., et al. Contemporary defi nitions and classification of the cardiomyopathies: an American Heart Association Scientifi c Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113(14):1807–1816. https://doi.org/10.1161/circulationaha.106.174287Maron B.J., Towbin J.A., Thiene G., Antzelevitch C., Corrado D., Arnett D., et al. Contemporary defi nitions and classification of the cardiomyopathies: an American Heart Association Scientifi c Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation. 2006;113(14):1807–1816. https://doi.org/10.1161/circulationaha.106.174287Sealove B.A., Tiyyagura S., Fuster V.J. Тakotsubo cardiomyopathy. J. Gen. Intern. Med. 2008;23(11):1904–1908. https://doi.org/10.1007/s11606-008-0744-4Sealove B.A., Tiyyagura S., Fuster V.J. Тakotsubo cardiomyopathy. J. Gen. Intern. Med. 2008;23(11):1904–1908. https://doi.org/10.1007/s11606-008-0744-4Sato H., Tateishi H., Uchida T., et al. Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama K., Haze K. Hom M, eds. Clinical aspect of myocardial injury: from ischemia to heart failure. Tokyo: Kagakuhyouronsya Co.; 1990, p. 56–64. (In Japanese).Sato H., Tateishi H., Uchida T., et al. Takotsubo-type cardiomyopathy due to multivessel spasm. In: Kodama K., Haze K. Hom M, eds. Clinical aspect of myocardial injury: from ischemia to heart failure. Tokyo: Kagakuhyouronsya Co.; 1990, p. 56–64. (In Japanese).Tsushikashi K., Ueshima K., Uchida T. Transient left ventricular apical ballooning syndrome without coronary artery stenosis; a novel heart syndrome mimicking acute myocardial infarction. J. Amer. Coll. Cardiology. 2001;38(1):11–18. https://doi.org/10.1016/s0735-1097(01)01316-xTsushikashi K., Ueshima K., Uchida T. Transient left ventricular apical ballooning syndrome without coronary artery stenosis; a novel heart syndrome mimicking acute myocardial infarction. J. Amer. Coll. Cardiology. 2001;38(1):11–18. https://doi.org/10.1016/s0735-1097(01)01316-xDesmet W.J., Adriaenssens B.F., Dens J.A. Apical ballooning of the left ventricle: first series in white patients. Heart. 2003;89(9):1027–1031. https://doi.org/10.1136/heart.89.9.1027Desmet W.J., Adriaenssens B.F., Dens J.A. Apical ballooning of the left ventricle: first series in white patients. Heart. 2003;89(9):1027–1031. https://doi.org/10.1136/heart.89.9.1027Gianni M., Dentali F., Grandi A.M., Sumner G., Hiralal R., Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur. Heart J. 2006;27(13):1523–1529. https://doi.org/10.1093/eurheartj/ehl032Gianni M., Dentali F., Grandi A.M., Sumner G., Hiralal R., Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur. Heart J. 2006;27(13):1523–1529. https://doi.org/10.1093/eurheartj/ehl032Cimarelli S., Sauer F., Morel O., Ohlmann P., Constantinesco A., Imperiale A. Transient left ventricular dysfunction syndrome: Pathophysiological bases through nuclear medicine imaging. Int. J. Cardiol. 2010;144(2):212–218. https://doi.org/10.1016/j.ijcard.2009.04.025Cimarelli S., Sauer F., Morel O., Ohlmann P., Constantinesco A., Imperiale A. Transient left ventricular dysfunction syndrome: Pathophysiological bases through nuclear medicine imaging. Int. J. Cardiol. 2010;144(2):212–218. https://doi.org/10.1016/j.ijcard.2009.04.025Khallafi H., Chacko V., Varveralis N., Elmi F. “Broken heart syndrome”: catecholamine surge or aborted myocardial infarction? J. Invasive Cardiol. 2008;20(1):E9–13.Khallafi H., Chacko V., Varveralis N., Elmi F. “Broken heart syndrome”: catecholamine surge or aborted myocardial infarction? J. Invasive Cardiol. 2008;20(1):E9–13.Pfister R., Erdmann E., Hoppe U.C. The Takotsubo syndrome-a psychosomatic cardiac complication? MMW Fortschr. Med. 2007;149(1–2):41–43.Pfister R., Erdmann E., Hoppe U.C. The Takotsubo syndrome-a psychosomatic cardiac complication? MMW Fortschr. Med. 2007;149(1–2):41–43.Yilmaz Y. Apical ballooning syndrome: A metabolic form of cardiomyopathy? Med. Sci. Monit. 2008;14(6):HY9–12.Yilmaz Y. Apical ballooning syndrome: A metabolic form of cardiomyopathy? Med. Sci. Monit. 2008;14(6):HY9–12.Finsterer J., Stollberger C., Sehnal E. et al. Apical ballooning (Takotsubo syndrome) in mitochondrial disorder during mechanical ventilation. J. Cardiovasc. Med (Hagerstown). 2007;8(10):859–863. https://doi.org/10.2459/JCM.0b013e3280103d1bFinsterer J., Stollberger C., Sehnal E. et al. Apical ballooning (Takotsubo syndrome) in mitochondrial disorder during mechanical ventilation. J. Cardiovasc. Med (Hagerstown). 2007;8(10):859–863. https://doi.org/10.2459/JCM.0b013e3280103d1bMcGavock J.M., Lingvay I., Zib I.,Tillery T., Salas N., Unger R., et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation. 2007;116(10):1170–1175. https://doi.org/10.1161/CIRCULATIONAHA.106.645614McGavock J.M., Lingvay I., Zib I.,Tillery T., Salas N., Unger R., et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation. 2007;116(10):1170–1175. https://doi.org/10.1161/CIRCULATIONAHA.106.645614Pilgrim T.M., Wyss T.R. Takotsubo cardiomyopathy or transient left ventricular ballooning syndrome. A systematic review. Int. J. Cardiol. 2008;124(3):283–292. https://doi.org/10.1016/j.ijcard.2007.07.002Pilgrim T.M., Wyss T.R. Takotsubo cardiomyopathy or transient left ventricular ballooning syndrome. A systematic review. Int. J. Cardiol. 2008;124(3):283–292. https://doi.org/10.1016/j.ijcard.2007.07.002Ito K., Sugihara H., Katoh S., Azuma A., Nakagawa M. Assessment of Takotsubo (ampulla) cardiomyopathy using 99mTc-tetrofosmin myocardial SPECT-comparison with acute coronary syndrome. Ann. Nucl. Med. 2003;17(2):115–122. https://doi.org/10.1007/BF02988449Ito K., Sugihara H., Katoh S., Azuma A., Nakagawa M. Assessment of Takotsubo (ampulla) cardiomyopathy using 99mTc-tetrofosmin myocardial SPECT-comparison with acute coronary syndrome. Ann. Nucl. Med. 2003;17(2):115–122. https://doi.org/10.1007/BF02988449Bybee K.A., Prasad A., Barsness G.W., Lerman A., Jaffe A.S., Murphy J.G., Wright R.S., Rihal C.S. Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am. J. Cardiol. 2004;94(3):343–346. https://doi.org/10.1016/j.amjcard.2004.04.030Bybee K.A., Prasad A., Barsness G.W., Lerman A., Jaffe A.S., Murphy J.G., Wright R.S., Rihal C.S. Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am. J. Cardiol. 2004;94(3):343–346. https://doi.org/10.1016/j.amjcard.2004.04.030Gianni M., Dentali F., Grandi A.M., Sumner G., Hiralal R., Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur. Heart J. 2006;27(13):1523–1529. https://doi.org/10.1093/eurheartj/ehl032Gianni M., Dentali F., Grandi A.M., Sumner G., Hiralal R., Lonn E. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur. Heart J. 2006;27(13):1523–1529. https://doi.org/10.1093/eurheartj/ehl032Eshtehardi P., Koestner S.C., Adorjan P., Windecker S., Meier B., Hess O.M., Wahl A., Cook S. Transient apical ballooning syndrome — clinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population. Int. J. Cardiol. 2009;135(3):370–375. https://doi.org/10.1016/j.ijcard.2008.03.088Eshtehardi P., Koestner S.C., Adorjan P., Windecker S., Meier B., Hess O.M., Wahl A., Cook S. Transient apical ballooning syndrome — clinical characteristics, ballooning pattern, and long-term follow-up in a Swiss population. Int. J. Cardiol. 2009;135(3):370–375. https://doi.org/10.1016/j.ijcard.2008.03.088von Korn H., Yu J., Lotze U. Ohlow M.-A., Huegl B., Schulte W., et al. Tako-Tsubo-like cardiomyopathy: specific ECG findings, characterization and clinical findings in a European single center. Cardiology. 2009;112(1):42–48. https://doi.org/10.1159/000137698von Korn H., Yu J., Lotze U. Ohlow M.-A., Huegl B., Schulte W., et al. Tako-Tsubo-like cardiomyopathy: specific ECG findings, characterization and clinical findings in a European single center. Cardiology. 2009;112(1):42–48. https://doi.org/10.1159/000137698Mathew B., Villarreal D. Two unusual cases of Takotsubo cardiomyopathy. presenting with sudden cardiac death. Am. J. Med. Sci. 2009;337(6):473–475. https://doi.org/10.1097/MAJ.0b013e3181956f49Mathew B., Villarreal D. Two unusual cases of Takotsubo cardiomyopathy. presenting with sudden cardiac death. Am. J. Med. Sci. 2009;337(6):473–475. https://doi.org/10.1097/MAJ.0b013e3181956f49Bybee K.A., Prasad A. Stress-related cardiomyopathy syndromes. Circulation. 2008;118(4):397–409. https://doi.org/10.1161/CIRCULATIONAHA.106.677625Bybee K.A., Prasad A. Stress-related cardiomyopathy syndromes. Circulation. 2008;118(4):397–409. https://doi.org/10.1161/CIRCULATIONAHA.106.677625Citro R., Previtali M., Bossone E. Tako-tsubo cardiomyopathy and drowning syndrome: is there a link? Chest. 2008;134(2):469. https://doi.org/10.1378/chest.08-0541Citro R., Previtali M., Bossone E. Tako-tsubo cardiomyopathy and drowning syndrome: is there a link? Chest. 2008;134(2):469. https://doi.org/10.1378/chest.08-0541Radhakrishnan A., Granato J.E. An association between Takotsubo cardiomyopathy and thyroid storm. Postgrad. Med. 2009;121(3):126–130. https://doi.org/10.3810/pgm.2009.05.2012Radhakrishnan A., Granato J.E. An association between Takotsubo cardiomyopathy and thyroid storm. Postgrad. Med. 2009;121(3):126–130. https://doi.org/10.3810/pgm.2009.05.2012Gelow J., Kruer M., Yadav V., Kaul S. Apical ballooning resulting from limbic encephalitis. Am. J. Med. 2009;122(6):583–586. https://doi.org/10.3810/pgm.2009.05.2012Gelow J., Kruer M., Yadav V., Kaul S. Apical ballooning resulting from limbic encephalitis. Am. J. Med. 2009;122(6):583–586. https://doi.org/10.3810/pgm.2009.05.2012Wakabayashi K., Dohi T., Daida H. Takotsubo cardiomyopathy associated with epilepsy complicated with giant thrombus. Int. J. Cardiol. 20011;148(2):e28–30.https://doi.org/10.1016/j.ijcard.2009.01.072Wakabayashi K., Dohi T., Daida H. Takotsubo cardiomyopathy associated with epilepsy complicated with giant thrombus. Int. J. Cardiol. 20011;148(2):e28–30.https://doi.org/10.1016/j.ijcard.2009.01.072Uechi Y., Higa K. Recurrent takotsubo cardiomyopathy within a short span of time in a patient with hereditary motor and sensory neuropathy. Intern. Med. 2008;47(18):1609–1613. https://doi.org/10.2169/internalmedicine.47.1186Uechi Y., Higa K. Recurrent takotsubo cardiomyopathy within a short span of time in a patient with hereditary motor and sensory neuropathy. Intern. Med. 2008;47(18):1609–1613. https://doi.org/10.2169/internalmedicine.47.1186Punnam S.R., Gourineni N., Gupta V. Takotsubo cardiomyopathy in a patient with Addison disease. Int. J. Cardiol. 2010;144(2):e34–36. https://doi.org/10.1016/j.ijcard.2008.12.191Punnam S.R., Gourineni N., Gupta V. Takotsubo cardiomyopathy in a patient with Addison disease. Int. J. Cardiol. 2010;144(2):e34–36. https://doi.org/10.1016/j.ijcard.2008.12.191Gangadhar T.C. Von der Lohe E., Sawada S.G., Helft P.R. Takotsubo cardiomyopathy in a patient with esophageal cancer: a case report. J. Med. Case Reports. 2008;2:379. https://doi.org/10.1186/1752-1947-2-379Gangadhar T.C. Von der Lohe E., Sawada S.G., Helft P.R. Takotsubo cardiomyopathy in a patient with esophageal cancer: a case report. J. Med. Case Reports. 2008;2:379. https://doi.org/10.1186/1752-1947-2-379Mahida S., Dalageorgou C., Behr E.R. Long-QT syndrome and torsades de pointes in a patient with Takotsubo cardiomyopathy: an unusual case. Europace. 2009;11(3):376–378. https://doi.org/10.1093/europace/eun336Mahida S., Dalageorgou C., Behr E.R. Long-QT syndrome and torsades de pointes in a patient with Takotsubo cardiomyopathy: an unusual case. Europace. 2009;11(3):376–378. https://doi.org/10.1093/europace/eun336Skolnick A.H., Michelin K., Nayar A., Fisher D., Kronzon I. Transient apical ballooning syndrome precipitated by dobutamine stress testing. Ann. Intern. Med. 2009;150(7):501–502. https://doi.org/10.7326/0003-4819-150-7-200904070-00015Skolnick A.H., Michelin K., Nayar A., Fisher D., Kronzon I. Transient apical ballooning syndrome precipitated by dobutamine stress testing. Ann. Intern. Med. 2009;150(7):501–502. https://doi.org/10.7326/0003-4819-150-7-200904070-00015Jayawardena S., Sooriabalan D., Burzyantseva O., Sinnapunayagm S. Takotsubo cardiomyopathy in a 68-year-old Russian female. Cases J. 2008;1(1):64. https://doi.org/10.1186/1757-1626-1-64Jayawardena S., Sooriabalan D., Burzyantseva O., Sinnapunayagm S. Takotsubo cardiomyopathy in a 68-year-old Russian female. Cases J. 2008;1(1):64. https://doi.org/10.1186/1757-1626-1-64Kawai S., Kitabatake A., Tomoike H. Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ. J. 2007;71(6):990–992. https://doi.org/10.1253/circj.71.990Kawai S., Kitabatake A., Tomoike H. Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ. J. 2007;71(6):990–992. https://doi.org/10.1253/circj.71.990Dib C., Asirvatham S., Elesber A., Rihal C., Friedman P., Prasad A. Clinical correlates and prognostic significance of electrocardiographic abnormalities in apical ballooning syndrome (Takotsubo/stress-induced cardiomyopathy. Am. Heart J. 2009;157(5):933–938. https://doi.org/10.1016/j.ahj.2008.12.023Dib C., Asirvatham S., Elesber A., Rihal C., Friedman P., Prasad A. Clinical correlates and prognostic significance of electrocardiographic abnormalities in apical ballooning syndrome (Takotsubo/stress-induced cardiomyopathy. Am. Heart J. 2009;157(5):933–938. https://doi.org/10.1016/j.ahj.2008.12.023Jim M.H., Chan A.O., Tsui P.T. et al. A new ECG criterion to identify takotsubo cardiomyopathy from anterior myocardial infarction: role of inferior leads. Heart Vessels. 2009;24(2):124–130. https://doi.org/10.1007/s00380-008-1099-9Jim M.H., Chan A.O., Tsui P.T. et al. A new ECG criterion to identify takotsubo cardiomyopathy from anterior myocardial infarction: role of inferior leads. Heart Vessels. 2009;24(2):124–130. https://doi.org/10.1007/s00380-008-1099-9Kimura S., Mitsuma W., Ito M., Suzuki H., Hosaka Y., Hirayama S., et al. Inverted Takotsubo contractile pattern caused by pheochromocytoma with tall upright T-waves, but not typical deep T-wave inversion. Int. J. Cardiol. 2008;139(2):e15–17. https://doi.org/10.1016/j.ijcard.2008.06.073Kimura S., Mitsuma W., Ito M., Suzuki H., Hosaka Y., Hirayama S., et al. Inverted Takotsubo contractile pattern caused by pheochromocytoma with tall upright T-waves, but not typical deep T-wave inversion. Int. J. Cardiol. 2008;139(2):e15–17. https://doi.org/10.1016/j.ijcard.2008.06.073Sealove B.A., Tiyyagura S., Fuster V. Takotsubo cardiomyopathy. J. Gen. Intern. Med. 2008;23(11):1904–1908. https://doi.org/10.1007/s11606-008-0744-4Sealove B.A., Tiyyagura S., Fuster V. Takotsubo cardiomyopathy. J. Gen. Intern. Med. 2008;23(11):1904–1908. https://doi.org/10.1007/s11606-008-0744-4Ramaraj R., Sorrell V.L., Movahed M.R. Levels of troponin release can aid in the early exclusion of stressinduced (takotsubo) cardiomyopathy. Exp. Clin. Cardiol. 2009;14(1):6–8.Ramaraj R., Sorrell V.L., Movahed M.R. Levels of troponin release can aid in the early exclusion of stressinduced (takotsubo) cardiomyopathy. Exp. Clin. Cardiol. 2009;14(1):6–8.Kurisu S., Inoue I., Kawagoe T., Ishihara M., Shimatani Y., Nakama Y., et al. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy. Coron. Artery Dis. 2009;20(3):214–218. https://doi.org/10.1097/MCA.0b013e3283299260Kurisu S., Inoue I., Kawagoe T., Ishihara M., Shimatani Y., Nakama Y., et al. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy. Coron. Artery Dis. 2009;20(3):214–218. https://doi.org/10.1097/MCA.0b013e3283299260Остроумов Е.Н., Нуднов Н.В., Артемова Е.В., Хорико ва Е.Н. Диагностика ампульной кардиомиопатии с помощью перфузионной томосцинтиграфии миокарда. Российский медицинский журнал.2006;(3):5–8.Ostroumov E.N., Nudnov N.V., Artemova E.V., Khorikova E.N. Diagnosis of ampoule cardiomyopathy using myocardial perfusion tomoscintigraphy. Rossiiskii meditsinskii zhurnal = Medical Journal of the Russian Federation. 2006;(3):5–8. (In Russ.).Mitchell J.H., Hadden T.B., Wilson J.M., Achari A., Muthupillai R., Flamm S.D. Clinical features of cardiac magnetic resonance imaging in assessing myocardial viability and prognosis in Tackotsubo cardiomyopathy (transient left ventricular apical ballooning syndrome). Am. J. Cardiology. 2007;100(2):296–301. https://doi.org/10.1016/j.amjcard.2007.02.091Mitchell J.H., Hadden T.B., Wilson J.M., Achari A., Muthupillai R., Flamm S.D. Clinical features of cardiac magnetic resonance imaging in assessing myocardial viability and prognosis in Tackotsubo cardiomyopathy (transient left ventricular apical ballooning syndrome). Am. J. Cardiology. 2007;100(2):296–301. https://doi.org/10.1016/j.amjcard.2007.02.091Gorenek B., Kudaiberdieva G., Taraktas M., Cavusoglu Y., Timuralp B., Goktekin O., Ata N., Unalir A. Correlation between left ventricular ejection fraction and cardiac troponin T concentration is more pronounced in patients with nonischemic cardiomyopathy. J. Electrocardiology. 2007;40(4):S75. https://doi.org/10.1016/j.jelectrocard.2007.03.039Gorenek B., Kudaiberdieva G., Taraktas M., Cavusoglu Y., Timuralp B., Goktekin O., Ata N., Unalir A. Correlation between left ventricular ejection fraction and cardiac troponin T concentration is more pronounced in patients with nonischemic cardiomyopathy. J. Electrocardiology. 2007;40(4):S75. https://doi.org/10.1016/j.jelectrocard.2007.03.039Sharkey S.W., Lesser J.R., Menon M., Parpart M., Maron M.S., Maron B.J. Spectrum and significance of electrocardiographic patterns, troponin levels, and thrombolysis in myocardial infarction frame count in patients with stress (tako-tsubo) cardiomyopathy and comparison to those in patients with ST-elevation anterior wall myocardial infarction. Am. J. Cardiol. 2008;101(12):1723–1728. https://doi.org/10.1016/j.amjcard.2008.02.062Sharkey S.W., Lesser J.R., Menon M., Parpart M., Maron M.S., Maron B.J. Spectrum and significance of electrocardiographic patterns, troponin levels, and thrombolysis in myocardial infarction frame count in patients with stress (tako-tsubo) cardiomyopathy and comparison to those in patients with ST-elevation anterior wall myocardial infarction. Am. J. Cardiol. 2008;101(12):1723–1728. https://doi.org/10.1016/j.amjcard.2008.02.062Madhavan M., Borlaug B.A., Lerman A., Rihal C.S., Prasad A. Stress Hormone and Circulating Biomarker Profi le of Apical Ballooning Syndrome (Takotsubo Cardiomyopathy): Insights into the Clinical Significance of BNP and Troponin Levels. Heart. 2009;95(17):1436–1441. https://doi.org/10.1136/hrt.2009.170399Madhavan M., Borlaug B.A., Lerman A., Rihal C.S., Prasad A. Stress Hormone and Circulating Biomarker Profi le of Apical Ballooning Syndrome (Takotsubo Cardiomyopathy): Insights into the Clinical Significance of BNP and Troponin Levels. Heart. 2009;95(17):1436–1441. https://doi.org/10.1136/hrt.2009.170399Yoshimura S., Toyoda K., Ohara T., Nagasawa H., Ohtani N., Kuwashiro T., Naritomi H., Minematsu K. Takotsubo cardiomyopathy in acute ischemic stroke. Ann. Neurol. 2008;64(5):547–554. https://doi.org/10.1002/ana.21459Yoshimura S., Toyoda K., Ohara T., Nagasawa H., Ohtani N., Kuwashiro T., Naritomi H., Minematsu K. Takotsubo cardiomyopathy in acute ischemic stroke. Ann. Neurol. 2008;64(5):547–554. https://doi.org/10.1002/ana.21459Doust J.A., Glasziou P.P., Pietrzak E., Dobson A.J. A systematic review of the diagnostic accuracy of natriuretic peptides for heart failure. Arch. Intern. Med. 2004;164(18):1978–1984. https://doi.org/10.1001/archinte.164.18.1978Doust J.A., Glasziou P.P., Pietrzak E., Dobson A.J. A systematic review of the diagnostic accuracy of natriuretic peptides for heart failure. Arch. Intern. Med. 2004;164(18):1978–1984. https://doi.org/10.1001/archinte.164.18.1978Nef H.M., Molman H., Kostin S., Troidl C., Voss S., Weber M., et al. Takotsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after structural recovery. Eur. Heart J. 2007;28(20):2456–2464.https://doi.org/10.1093/eurheartj/ehl570Nef H.M., Molman H., Kostin S., Troidl C., Voss S., Weber M., et al. Takotsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after structural recovery. Eur. Heart J. 2007;28(20):2456–2464.https://doi.org/10.1093/eurheartj/ehl570Okada T., Miyata S., Hashimoto K., Maie K., Mochizuki S. Takotsubo cardiomyopathy associated with torsades de pointes and long QT interval: a case report. J. Cardiol. 2007;50(1):83–88.Okada T., Miyata S., Hashimoto K., Maie K., Mochizuki S. Takotsubo cardiomyopathy associated with torsades de pointes and long QT interval: a case report. J. Cardiol. 2007;50(1):83–88.Haghi D., Papavassiliu T., Heggemann F., Kaden J.J., Borggrefe M., Suselbeck T. Incidence and clinical significance of left ventricular thrombus in tako-tsubo cardiomyopathy assessed with echocardiography. QJM. 2008;101(5):381–386. https://doi.org/10.1093/qjmed/hcn017Haghi D., Papavassiliu T., Heggemann F., Kaden J.J., Borggrefe M., Suselbeck T. Incidence and clinical significance of left ventricular thrombus in tako-tsubo cardiomyopathy assessed with echocardiography. QJM. 2008;101(5):381–386. https://doi.org/10.1093/qjmed/hcn017Лиманкина И.Н. Кардиомиопатия такотсубо. Вестник аритмологии. 2009;56:48–58.Limankina I.N. Tako Tsubo Cardiomyopathy. Vestnik of Atitmologii= Journal of Arrhythmology. 2009;(56):48–58. (In Russ.).

The authors declare that there are no conflicts of interest present.