smjournalСпортивная медицина: наука и практикаSports medicine: research and practice2223-25242587-9014NEICONsmjournal-91Research ArticleСПОРТИВНОЕ ПИТАНИЕSPORTS SUPPLEMENTSПрименение фосфатидной кислоты в спорте: реальность или миф?Application of phosphatidic acid in sport: reality or myth?ГольбергН. Д.GolbergN. D.ndgolberg@gmail.comРогозкинВ. А.RogozkinV. А.noemail@neicon.ruФГБУ Санкт-Петербургский научно-исследовательский институт физической культуры, Министерство спорта РФRussian Federation201821082020814754Copyright © Гольберг Н.Д., Рогозкин В.А., 20202020Гольберг Н.Д., Рогозкин В.А.Golberg N.D., Rogozkin V.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.smjournal.ru/jour/article/view/91

Фермент mTOR играет важную роль в передаче внеклеточных сигналов через фосфорилирование многочисленных субстратов в различных метаболических реакциях организма человека. Экспрессия mTOR происходит в ответ на изменение метаболических запросов мышечной клетки и приводит к усилению метаболизма белков. Среди веществ повышающих каталитическую активность mTOR одно из главных мест занимает фосфатидная кислота, содержание которой в скелетных мышцах повышается при выполнении физических нагрузок. Исследования последних лет свидетельствуют о важной роли фосфатидной кислоты в повышении интенсивности синтеза мышечных белков. Все это указывает на необходимость рассмотрения современного состояния знаний об участии фосфатидной кислоты в регуляции метаболизма скелетных мышц. В обзоре представлены результаты исследований, опубликованные за последние несколько лет, которые расширяют представления о действии фосфатидной кислоты в организме человека.

The mTOR enzyme plays an important role in the transmission of extracellular signals through the phosphorylation of numerous substrates in various metabolic reactions of the human body. Expression of mTOR occurs in response to changes in metabolic demands of the muscle cell and leads to increased protein metabolism. Among the substances that increase the catalytic activity of mTOR one of the main places is occupied by phosphatidic acid, the content of which in skeletal muscles increases when performing physical exertion. Studies of recent years indicate the important role of phosphatidic acid in increasing the intensity of the synthesis of muscle proteins. So, there is the need to consider the current state of knowledge about the involvement of phosphatidic acid in the regulation of skeletal muscle metabolism. The review presents the results of studies published over the last few years, which expand the understanding of the effects of phosphatidic acid in the human body.

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The authors declare that there are no conflicts of interest present.