Тhe study of Association of gene polymorphism with sports success and risk of alimentary-dependent diseases in athletes representing cyclic sports
https://doi.org/10.17238/ISSN2223-2524.2019.3.41
Abstract
The studies of genetic polymorphisms rs1815739 (ACTN3 gene), rs2016520 (gene PPARD), rs1042713 (ADRB2 gene), rs1799945 (HFE gene), rs1801282 (PPARG gene) of athletes involved in cyclic sports were carried out. Genotyping was performed using allele-specific amplification with real-time detection of results and the use of TaqMan probes. As a result of the research, a higher incidence of alleles associated with endurance (T-polymorphism rs1815739 and G - polymorphism rs2016520) was revealed in athletes of cyclic sports. The analysis of the results of genetic polymorphisms: rs9939609 gene FTO, ADRB3 rs4994 gene rs2228570 and VDR gene showed that the risk of development of alimentary-related diseases (obesity and osteoporosis) in the examined athletes after sports career is lower than in the General population.
About the Authors
E. Yu. Sorokina
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Elena Yu. Sorokina, M.D., PhD (Medicine), Leading Researcher of the Laboratory of Epidemiology of Nutrition and Genodiagnostics of Alimentary-Dependent Diseases
Moscow
E. E. Keshabyants
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Evelina E. Keshabyants, M.D., PhD (Medicine), Senior Researcher of the Laboratory of Epidemiology of Nutrition and Genodiagnostics of Alimentary-Dependent Diseases
Moscow
N. N. Denisova
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Natalia N. Denisova, M.D., PhD (Medicine), Scientist of the Laboratory of Epidemiology of Nutrition and Genodiagnostics of Alimentary-Dependent Diseases
Moscow
+7 (985) 280-40-75
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Review
For citations:
Sorokina E.Yu., Keshabyants E.E., Denisova N.N. Тhe study of Association of gene polymorphism with sports success and risk of alimentary-dependent diseases in athletes representing cyclic sports. Sports medicine: research and practice. 2019;9(3):41-48. (In Russ.) https://doi.org/10.17238/ISSN2223-2524.2019.3.41
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