Hidden metabolic disorders in high-class athletes
https://doi.org/10.47529/2223-2524.2020.4.3
Abstract
Objective: to reveal the frequency of deviations occurrence in individual biochemical indicators, which can be markers of hidden metabolicconditioned deviations in the health of athletes.
Materials and methods. Members of sports teams of Russia at the age of 16 to 38 years were examined. The total number of examined athletes was 5245: 3167 were male athletes and 2078 were female athletes. We studied 25 indicators of the biochemical composition of blood, showing latent metabolic disorders and the activity of its regulators, negative shifts in the functional state of individual physiological systems of the body and possible damage to tissues of individual organs.
Results. Reference ranges and their centile gradations were calculated on the basis of a large array of data for 25 biochemical parameters. The use of centile gradations in assessing the values of blood biochemical parameters, recorded during the current monitoring in athletes, makes it possible to establish the vector of their changes and timely make changes in the volume and orientation of training loads, as well as to reasonably develop individualized programs for the athlete’s metabolic support. The use of the centile approach and the formation on its basis of gradation scales for each of the studied blood biochemical parameters also made it possible to establish the percentage of persons with significant deviations in certain biochemical parameters among the studied sample of athletes, admitted to the training process within the framework of in-depth medical examinations (DMO).
Conclusion: such deviations from the norm may indicate hidden metabolic disorders that occur against the background of professional sports loads, and in the absence of timely compensation, they can lead to a breakdown in adaptation and the development of various metabolic-related pathologies
About the Authors
Zh. V. GrishinaRussian Federation
Zhanna V. Grishina — M.D., Ph.D. (Biology), biochemist of the Cabinet of functional state correction
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
G. A. Makarova
Russian Federation
Galina A. Makarova — M.D., D.Sc. (Medicine), Professor, Chief Researcher of the Research Institute of Problems of Physical Culture and Sports
161 Budyonny str., microdistrict Central, Krasnodar, 350015
S. A. Bazanovich
Russian Federation
Sergey A. Bazanovich — Junior Researcher of the Organizational-Research Department
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
S. M. Chernuha
Russian Federation
Svetlana M. Chernuha— Senior Researcher, Research Institute of Physical Culture and Sports
161 Budyonny str., microdistrict Central, Krasnodar, 350015
M. Ya. Yadgarov
Russian Federation
Mihail Ya.Yadgarov — Junior Researcher of the Organizational-Research Department
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
V. S. Feshchenko
Russian Federation
Vladimir S. Feshchenko — M.D., Ph.D. (Medicine), Head of the Organizational-Research Department
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
A. A Pavlova
Russian Federation
Anna A. Pavlova — Junior Researcher of the Organizational-Research Department
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
E. A. Anisimov
Russian Federation
Evgeniy A. Anisimov — sports medicine physician
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
T. A. Yashin
Russian Federation
Timofey A. Yashin — Head of the Correction sportsmen’s performance Department
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
A. V. Zholinskij
Russian Federation
Andrey V. Zholinsky — M.D., Ph.D. (Medicine), Director
5 Bolshaya Dorogomilovskaya str., Moscow, 121059
References
1. Makarova G.A., Kolesnikova N.V., Skibitsky V.V., Baranovskaya I.B. Diagnostic potential of blood picture in athletes. Moscow: Sport; 2020. 256 p. (In Russ.).
2. Makarova G.A., Achkasov E.E., Baranovskaya I.B. Biochemical control in sports: the main directions of increasing efficiency. Sportivnaya medicina nauka i praktika = Sports medicine: research and practice. 2017;7(1): 46–52 (In Russ.).
3. Nikulin B., Rodionova I. Biochemical control in sports. Moscow: Soviet Sport; 2011. 232 p. (In Russ.).
4. Gunina L.M., Oleinik S.A. Biochemical and hematological control and its importance in the development of pharmacological support schemes for training and competitive activity of athletes. Nauka v olimpiiskom sporte = Science in Olympic Sport. 2009;(1):177–193 (In Russ.).
5. Nikolaidis M.G., Protosygellou M.D., Petridou A., Tsalis G., Tsigilis N., Mougios V. Hematologic and biochemical profile of juvenile and adult athletes of both sexes: Implications for clinical evaluation. Int J Sports Med. 2003;24(7):506–511. https://doi.org/10.1055/s-2003-42014
6. Inman L.A., Rennie M.J., Watsford M.L., Gibbs N.J., Green J., Spurrs R.W. Reference values for the creatine kinase response to professional Australian football match-play. J Sci Med Sport. 2018;21(8):852–857. https://doi.org/10.1016/j.jsams.2017.12.013
7. Witek K., Ścisłowska J., Turowski D., Lerczak K., Lewandowska-Pachecka S., Pokrywka A. Total bilirubin in athletes, determination of reference range. Biol Sport. 2017;34(1):45–48. https://doi.org/10.5114/biolsport.2017.63732
8. Henny J., Vassault A., Boursier G., Vukasovic I., Brguljan P.M., Lohmander M., Thelen M.H., et al. Recommendation for the review of biological reference intervals in medical laboratories. Clin Chem Lab Med. 2016;54(12):1893–1900. https://doi.org/10.1515/cclm-2016-0793
9. Mougios V. Reference intervals for serum creatine kinase in athletes. Br. J. Sports Med. 2007;41(10):674–678. https://doi.org/10.1136/bjsm.2006.034041
10. Banfi G., Del Fabbro M. Serum creatinine values in elite athletes competing in 8 different sports: Comparison with sedentary people. Clinical Chemistry. 2006;52(2):330–331. https://doi.org/10.1373/clinchem.2005.061390
11. Bazanovich S.A., Grishina Zh.V., Pavlova A.A., Feshchenko V.S., Yadgarov M.Ya. Development of reference intervals for the values of the main biochemical blood parameters of sports teams athletes from the Russian Federation. Reference intervals construction for the main biochemical blood parameters values in athletes of sports national teams of the Russian Federation. In: Collection of abstracts of the XIV international scientific conference on the state and prospects for medicine development in high-performance sports “SPORTMED-2019.” Moscow: Russian Association for Sports Medicine and Rehabilitation of Sick and Disabled People; 2019, p. 32–33 (In Russ.).
12. Ushakov A.A. Using the centile method of statistics in the practice of scientific research. Uspekhi sovremennogo estestvoznaniya = Advances in current natural sciences. 2008;(5):150–151 (In Russ.).
Review
For citations:
Grishina Zh.V., Makarova G.A., Bazanovich S.A., Chernuha S.M., Yadgarov M.Ya., Feshchenko V.S., Pavlova A.A., Anisimov E.A., Yashin T.A., Zholinskij A.V. Hidden metabolic disorders in high-class athletes. Sports medicine: research and practice. 2020;10(4):64-75. (In Russ.) https://doi.org/10.47529/2223-2524.2020.4.3