Frequency of occurrence of genetic polymorphisms associated with sports success in elite athletes in team sports
https://doi.org/10.47529/2223-2524.2021.1.11
Abstract
Objective: to evaluate the frequency of occurrence of polymorphisms rs1815739 (ACTN3 gene), rs2016520 (PPARD gene), rs1042713 (ADRB2 gene), rs1799945 (HFE gene) in athletes of highperformance sports.
Materials and methods: genotyping was performed using allelespecific amplification with realtime detection of the results and using TaqMan probes.
Results: a higher frequency of alleles associated with endurance was found: the t allele of the rs1815739 polymorphism (ACTN3 gene), the g allele of the rs2016520 polymorphism (PPARD gene), the g allele of the rs1042713 polymorphism (ADRB2 gene), and the g allele of the rs1799945 polymorphism (HFE gene) in athletes of game sports.
Conclusion: the results of genotyping of polymorphisms associated with endurance in the examined athletes showed a higher frequency of occurrence than in the population as a whole.
About the Authors
E. Yu. Sorokina
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Elena Yu. Sorokina, M.D., Ph.D. (Medicine), Leading Researcher of the Laboratory of Demography and Epidemiology of Nutrition
2/14, Ustinskij travel, Moscow, 109240
N. N. Denisova
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Natalia N. Denisova, M.D., Ph.D. (Medicine), researcher of the Laboratory of Demography and Epidemiology of Nutrition and Genodiagnostics of Alimentary-Dependent Diseases
2/14, Ustinskij travel, Moscow, 109240
+7 (985) 280-40-75
E. E. Keshabyants
Federal Research Centre of Nutrition, Biotechnology and Food Safety
Russian Federation
Russian Federation
Evelina E. Keshabyants, M.D., Ph.D. (Medicine), Senior researcher of the Laboratory of Demography and Epidemiology of Nutrition and Genodiagnostics of Alimentary-Dependent Diseases
2/14, Ustinskij travel, Moscow, 109240
References
1. Borisova O.O. Nutrition of athletes: foreign experience and practical recommendations: textbook. Moscow: Sovetskii sport Publ.; 2007. 132 p. (In Russ.).
2. Putro L.M. Features of nutrition of football players. Nauka v olimpiiskom sporte = Science in Olympic sport. 2013;(1): 66–70 (In Russ.).
3. Alfred T., Ben-Shlomo Y., Cooper R. ACTN3 genotype, athletic status, and life course physical capabi lity: meta-analysis of the published literature and findings from nine studies. Human Mutation. 2011;32(9):1008–1018. https://doi.org/10.1002/humu.21526
4. Fang M., Yang Yu., Li X., Zhou F., Cao G., Li M., Gao L. The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PloS One. 2013;8(1): e54685. https://doi.org/10.1371/journal.pone.0054685
5. Baltazar-Martins G., Gutiérrez-Hellín J., Aguilar-Navarro M., Ruiz-Moreno C., Moreno-Pérez V., López-Samanes A., et al. Effect of ACTN3 Genotype on Sports Performance, Exercise-Induced Muscle Damage, and Injury Epidemiology. Sports. 2020;8(7):99. https://doi.org/10.3390/sports8070099
6. Seto J.T., Quinlan K.G., Lek M. ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling. J. Clin. Invest. 2013;123(10):4255–4263. https://doi.org/10.1172/JCI67691
7. Eynon N., Ruiz J.R., Femia P., Pushkarev V.P., Cieszczyk P. The ACTN3 R577X Polymorphism across Three Groups of Elite Male European Athletes. PLoS One. 2012;7(8):e43132. https://doi.org/10.1371/journal.pone.0043132
8. Galeandro V., Notarnicola A., Bianco A., Tafuri S., Russo L., Pesce V., et al. ACTN3/ACE genotypes and mitochondrial genome in professional soccer players performance. J. Biol. Regul. Homeost. Agents. 2017;31(1):207–213.
9. Malyarchuk B.A., Derenko M.V., Denisova G.A. R577X-polymorphism of alpha-actinin-3 in human populations in North-East Asia. Ekologicheskaya genetika = Ecological genetics. 2017;15(1):50–56 (In Russ.).
10. Sorokina E.Yu., Keshabyants E.E., Denisova N.N. Тhe study of Association of gene polymorphism with sports success and risk of alimentary-dependent diseases in athletes representing cyclic sports. Sportivnaya meditsina: nauka i praktika = Sports Medicine: Research and Practice. 2019;9(3):41–48 (In Russ.). https://doi.org/10.17238/ISSN2223-2524.2019.3.41
11. Miao L., Yin R-X., Wu D-F., Cao X-L., Li Q., Hu X-J., et al. Peroxisome proliferator-activated receptor delta +294T > C polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids in Health and Disease. 2010;9:145. https://doi.org/10.1186/1476-511X-9-145
12. Akhmetov I.I., Astratenkova I.V., Rogozhkin V.A. Association of PPARD gene polymorphism with human physical activity. Molekulyarnaya biologiya = Molecular biology. 2007;41(5):852–857 (In Russ.).
13. Petr M., Maciejewska-Skrendo A., Zajac A., Chycki J., Stastny P. Association of Elite Sports Status with Gene Variants of Peroxisome Proliferator Activated Receptors and Their Transcriptional Coactivator. Int. J. Mol. Sci. 2020;21(1):162. https://doi.org/10.3390/ijms21010162
14. Shepelevich N.V., Lebed T.L., Melnov S.B. Features of genetic profile of endurance in athletes-rowers. Ekologicheskii vestnik = Environmental Bulletin. 2013;(4(26):20–24 (In Russ.).
15. Wolfarth B., Rankinen T., Mühlbauer S., Scherr J., Boulay M.R., Pérusse L., et al. Association between a beta 2-adrenergic receptor polymorphism and elite endurance performance. Metabolism. 2007;56(12):1649–1651. https://doi.org/10.1016/j.metabol.2007.07.006
16. Imanbekova M.K., Zholdybaeva E.V., Esentaev T.K., Momynaliev K.T. Sport and genetics. Biotekhnologiya. Teoriya i praktika = Eurasian Journal of Applied. 2013;(2):4–11 (In Russ.).
17. dbSNP Short Genetic Variations [Internet]. National Center for Biotechnology Information. Available from: https://www.ncbi.nlm.nih.gov/snp/rs1042713#frequency_tab
18. Timasheva Y.R., Nasibullin T.R., Imaeva E.B., Mirzaeva G.Kh., Mustafina O.E. Gene Polymorphism of beta-adrenergic receptors and the risk of essential hypertension. Arterial’naya gipertenziya = Arterial Hypertension. 2015;21(3):259–266 (In Russ.). https://doi.org/10.18705/1607-419X-2015-21-3-259-266
19. Semenova E.A., Valeeva E.V., Bulygina E.A., Gubaidulina S.I., Akhmetov I.I. Application of complex technologies in the system of sports training. Uchenye Zapiski Kazanskogo Universiteta. Seriya Estestvennye Nauki = Proceedings of Kazan University. Natural Sciences Series. 2017;159(2):232–247 (In Russ.).
20. Agudo А., Bonet С., Sala N., Muñoz X., Aranda N., Nunes A.F. Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Carcinogenesis. 2013;34(6):1244–1250. https://doi.org/10.1093/carcin/bgt045.
21. Sorokina E.Yu., Pogozheva A.V., Nikityuk D.B. Study of Association of gene polymorphism with nutrition and nutritional status of martial arts athletes. Sportivnaya meditsina: nauka i praktika = Sports Medicine: Research and Practice. 2019;9(1):40–46 (In Russ.). https://doi.org/10.17238/ISSN2223-2524.2019.1.40
Review
For citations:
Sorokina E.Yu., Denisova N.N., Keshabyants E.E. Frequency of occurrence of genetic polymorphisms associated with sports success in elite athletes in team sports. Sports medicine: research and practice. 2021;11(1):5-10. (In Russ.) https://doi.org/10.47529/2223-2524.2021.1.11
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