Study of the joint action of coenzyme Q10 and royal jelly on the hematological and spirometric indicators in the elite athletes

Objective: to study the effects of royal jelly and coenzyme Q10 administered with food on the number of hematological and spirometric indicators in elite swimmers in precompetitive period. Materials and methods: 16 highly qualified athletes at the age of 19,8±0,6 years participated in the study. Content of erythrocytes and different white blood cells and level of hemoglobin in the blood of the athletes were measured using hematology analyzer «Abacus Junior 30». The measurement of respiratory volume, respiratory minute volume, respiratory frequency, рO₂ and рCO₂ in expired air, alveolar рO₂ and рCO₂ in the subjects was made using anesthesia breathing apparatus «Capnomac Ultima». Results: the administration of the above mix by the athletes stimulates the immune system and the oxygen-transporting function of blood, activates the functional state of pulmonary tissue, increases the oxygen consumption and improves physical performance. Conclusions: the effect of preventive therapy on the analyzed parameters in highly qualified swimmers determine the feasibility of the competent intake of composition «royal jelly-ubiquinone-10-honey» before and during major competitions when the requirements are high.

royal jelly, coenzyme Q10, erythrocytes, leucocytes, oxygen consumption, physical workload

1. Конторщикова К.Н., Крылов В.Н., Овчинников А.Н., Тихомирова Ю.Р., Колегова Т.И., Торшакова Г.А. Оценка влияния фармакологической композиции «мёд-маточное молочко-убихинон-10» на прооксидантно-антиоксидантный гомеостаз спортсменов // Медицинский альманах. 2017. №2. С. 104-7. DOI: 10.21145/2499-9954-2017-2-104-107.

2. Крылов В.Н., Агафонов А.В., Кривцов Н.И., Лебедев В.И., Бурмистрова Л.А., Ошевенский Л.В., Сокольский С.С. Теория и средства апитерапии. М.: Комильфо, 2007. 296 с.

3. Овчинников А.Н., Селезнёв В.В., Крылова Е.В., Крылов В.Н. Влияние пчелиного маточного молочка и убихинона-10 на содержание гемоглобина и лактата в крови высококвалифицированных пловцов в предсоревновательном периоде // Теория и практика физической культуры. 2016. №11. С. 29-31.

4. Смирнова А.В. Лабораторные работы большого практикума по физиологии и биохимии человека и животных. Раздел: физиология крови. Н. Новгород: ННГУ, 1995. 31 с.

5. World Medical Association Declaration of Helsinki. Recommendation guiding physicians in biomedical research involving human subjects // Journal of the American Medical Association. 1997. Vol.277, №11. P. 925-6. DOI: 10.1001/ jama.1997.03540350075038. URL: https://jamanetwork.com/ journals/jama/article-abstract/414713.

6. Bogdanov S. Royal jelly, bee brood: composition, health, medicine: a review // Bee Product Science. 2012. Vol.12. P. 1-32.

7. Zahran AM, Elsayh KI, Saad K, Eloseily EM, Osman NS, Alblihed MA, Badr G, Mahmoud MH. Effects of royal jelly supplementation on regulatory T cells in children with SLE // Food & Nutrition Research. 2016. Vol.60. P. 32963. DOI: 10.3402/fnr.v60.32963.

8. Morita H, Ikeda T, Kajita K, Fujioka K, Mori I, Okada H, Uno Y, Ishizuka T. Effect of royal jelly ingestion for six months on healthy volunteers // Nutrition Journal. 2012. Vol. 11, №1. P. 77. DOI: 10.1186/1475-2891-11-77.

9. Watanabe K, Shinmoto H, Kobori M, Tsushida T, Shinohara K, Kanaeda J, Yonekura M. Growth stimulation with honey royal jelly DIII protein of human lymphocytic cell lines in a serumfree medium // Biotechnology Techniques. 1996. Vol.10, №12. P. 959-62. DOI:10.1007/BF00180402.

10. Kurkure NV, Kognole SM, Pawar SP, Ganorkar AG, Bhandarkar AG, Inglel VC, Kalorey DR. Effect of royal jelly as immunomodulator in chicks // Journal of Immunology & Immunopathology. 2000. Vol.2, №1/2. P 84-7.

11. Pavel CI, Marghitas LA, Bobis O, Dezmirean DS, Sapcaliu A, Radoi I, Madas MN. Biological activities of royal jelly -review // Animal Science and Biotechnologies. 2011. Vol.44, №2. P. 108-18.

12. Крылов В.Н., Лукьянова Л.Д. Антигипоксическое действие экзогенного убихинона (коэнзима Q). В моногр.: Проблемы гипоксии: молекулярные, физиологические и медицинские аспекты. М., 2004. С. 488-513.

13. Ali AM, Awaad AG. Protective effect of coenzyme q10 against exercise-induced oxidative stress-mediated muscle fatigue in professional sportsmen // Pharmanest. 2014. Vol.5, №3. P. 2011-8.

14. Armanfar M, Jafari A, Dehghan GR. Effect of coenzyme Q10 supplementation on exercise-induced response of oxidative stress and muscle damage indicators in male runners // Zahedan Journal of Research in Medical Sciences. 2015. Vol.17, №8. P. 29-33. DOI: 10.17795/zjrms1023.

15. Demirci N. Effect of 14-day coenzyme Q10 supplement in male skiers on VO2max and respiratory parameters // Sylvan. 2015. Vol.159, №6. P 350-9.

16. Gharahdaghi N, Shabkhiz F, Azarboo E, Keyhanian A. The effects of daily coenzyme Q10 supplementation on VO2max, vVO2max and intermittent exercise performance in soccer players // Life S2mcaixence Journal. 2013. Vol.10, №8s. P. 22-8.

17. Ylikoski T, Piirainen J, Hanninen O, Penttinen J. The effect of coenzyme Q10 on the exercise performance of crosscountry skiers // Molecular Aspects of Medicine. 1997. Vol. 18. P. 283-90. DOI: 10.1016/S0098-2997(97)00038-1.

18. Khanvari T, Rezaei B, Sardari F, Safaeipour S. The effect of 14 days coenzyme Q10 supplementation on muscle damage markers and fatigue in inactive male // International Journal of Sport Studies. 2016. Vol.6, №4. P. 220-6.

19. Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure // Biofactors. 2003. Vol.18, №1-4. P. 91-100. DOI: 10.1002/biof.5520180211.

20. Leelarungrayub D, Sawattikanon N, Klaphajone J, Pothongsunan P, Bloomer RJ. Coenzyme Q10 supplementation decreases oxidative stress and improves physical performance in young swimmers: a pilot study // The Open Sports Medicine Journal. 2010. Vol.4. P. 1-8. DOI: 10.2174/1874387001004010001.

21. Gokbel H, Gul I, Belviranl M, Okudan N. tte effects of coenzyme Q10 supplementation on performance during repeated bouts of supramaximal exercise in sedentary men // Journal of Strength and Conditioning Research. 2010. Vol.24, №1. P. 97-102. DOI: 10.1519/JSC.0b013e3181a61a50.

22. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update // Nutrition. 2010. Vol.26, №3. P. 250-4. DOI: 10.1016/j. nut.2009.08.008.

23. Terada Y, Narukawa M, Watanabe T. Specific hydroxy fatty acids in royal jelly activate TRPA1 // Journal of Agricultural and Food Chemistry. 2011. Vol.59, №6. P. 2627-35. DOI: 10.1021/jf1041646.

24. El-Hanoun AM, Elkomy AE, Fares WA, Shahien EH. Impact of royal jelly to improve reproductive performance of male rabbits under hot summer conditions // World Rabbit Science. 2014. Vol.22. P. 241-8. DOI: 10.4995/wrs.2014.1677.