Development of overtraining syndrome: survey of hypotheses
https://doi.org/10.17238/ISSN2223-2524.2019.2.5
Abstract
This review presents current summarized knowledge on definition, causes, symptoms and evidence of overtraining syndrome in athletes. Analysis of biochemical, physiological, endocrine, neuronal and mycological parameters, each of which is potentially involved in understanding of the metabolic aspects of overtraining syndrome, is required to study the latter. The development of overtraining syndrome is explained by numerous hypotheses with their own strengths and weaknesses. Each theory is centered around a key parameter, disbalance of which can lead to overtraining during the execution of long-term high intensity training loads. Obviously none of isolated markers can be used for diagnostic purposes. A comprehensive approach to explain overtraining syndrome development is provided by a theory of cytokines.
About the Authors
M. A. Dikunets
Federal Science Center for Physical Culture and Sport
Russian Federation
Russian Federation
Marina A. Dikunets, Ph.D. (Chemistry), Leading Researcher of the Laboratory of Problems of Athletic Performance
Moscow
G. A. Dudko
Federal Science Center for Physical Culture and Sport
Russian Federation
Russian Federation
Grigory A. Dudko, Senior Researcher of the Laboratory of Problems of Athletic Performance
Moscow
E. N. Shachnev
Scientific Center «EFiS» LLC
Russian Federation
Russian Federation
Evgeniy N. Shachnev, Deputy General Manager for Development
Moscow
E. B. Myakinchenko
Federal Science Center for Physical Culture and Sport
Russian Federation
Russian Federation
Evgeniy B. Myakinchenko, D.Sc. (Education), Leading Researcher of the Laboratory of Problems of Athletic Performance
Moscow
O. V. Lyang
People’s Friendship University of Russia
Russian Federation
Russian Federation
Olga V. Lyang, Ph.D. (Biology), Associate Professor of the Department of Hospital Therapy with Clinical Laboratory Diagnostic Course
Moscow
References
1. Meeusen R, Duclos M, Foster C, Fry A, Gleeson M, Nieman D, Raglin J, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis, and treatment of the overtraining syndrome: joint consensus statement of the European College of Sport Science and the American College of Sports Medicine. Med. Sci. Sports Exerc. 2013;45(1):186-205. DOI: 10.1249/MSS.0b013e318279a10a.
2. Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and the treatment of the overtraining syndrome. Eur. J. Sport Sci. 2006;6(1):1-14. DOI: 10.1249/MSS.0b013e318279a10a.
3. Makarova GA, Volkov SN, Kholyavko YuA, Loktev SA. Overtraining syndrome in athletes (review of national and foreign literature) Part 1. Physical culture, sport – science and practice. 2014;3:29-37. Russian.
4. Kreher JB, Schwartz JB. Overtraining syndrome: a practical guide. Sports Health. 2012;4(2):128-38. DOI: 10.1177/1941738111434406.
5. Petibois C, Cazorla G, Poortmans JR, Déléris G. Biochemical aspects of overtraining in endurance sports: a review. Sports Med. 2002;32(13):867-78. DOI: 10.2165/00007256-200232130-00005.
6. Bosquet L, Leger L, Legros P. Blood lactate response to overtraining in male endurance athletes. Eur. J. Appl. Physiol. 2001;84(1-2):107-14. DOI: 10.1007/s004210000343.
7. Snyder AC, Jeukendrup AE, Hesselink MK, Kuipers H, Foster C. A physiological/psychological indicator of over-reaching during intensive training. Int. J. Sports Med. 1993;14(1):29-32. DOI: 10.1055/s-2007-1021141.
8. Meeusen R, Duclos M, Gleeson M, Rietjens G, Steinacker J, Urhausen A. Prevention, diagnosis and treatment of the overtraining syndrome. Eur. J. Sport Sci. 2006;6(1):1-14. DOI: 10.1249/MSS.0b013e318279a10a.
9. Newsholme EA. Biochemical mechanisms to explain immunosuppression in well-trained and overtrained athletes. Int. J. Sports Med. 1994;15(3):142-7. DOI: 10.1055/s-2007-1021129.
10. Blomstrand E, Hassmen P, Ek S, Ekblom B, Newsholme EA. Influence of ingesting a solution of branched-chain amino acids on perceived exertion during exercise. Acta Physiol. Scand. 1997;159(1):41-9. DOI: 10.1046/j.1365-201X.1997.547327000.x.
11. Hiscock N, Pedersen BK. Exercise-induced immunodepression – plasma glutamine is not the link. J. Appl. Physiol. 2002;93:813- 22. DOI: 10.1152/japplphysiol.00048.2002.
12. Parry-Billings M, Budgett R, Koutedakis Y, Blomstrand E, Brooks S, Williams C, Calder PC, Pilling S, Baigrie R, Newsholme EA. Plasma amino acid concentrations in the overtraining syndrome: possible effects on the immune system. Med. Sci. Sports Exerc. 1992;24(12):1353-8. DOI: 10.1249/00005768-199212000-00008.
13. Pyne DB, McDonald WA, Gleeson M, Flanagan A, Clancy RL, Fricker PA. Mucosal immunity, respiratory illness, and competitive performance in elite swimmers. Med. Sci. Sports Exerc. 2000;33(3):348-53.
14. Calder PC, Newsholme EA. Polyunsatturated fatty acids suppress human peripheral blood lymphocyte proliferation and interleukin-2 production. Clin. Sci. 1992;82(6):695-700.
15. Aïssa-Benhaddad A, Bouix D, Khaled S, Micallef JP, Mercier J, Bringer J, Brun JF. Early hemorheologic aspects of overtraining in elite athletes. Clin. Hemorheol. Microcirc. 1999; 20(2):117-25.
16. Lehmann M, Gastmann U, Lormes W. Influence of intensified training on neuroendocrine axes regulation: possible impact of tissue markers like leptin, inhibin B, vitamin D. «3rd Colloque Biologie de l’exercice musculaire». 2001:51.
17. Ishigaki T, Koyama K, Tsujita J, Tanaka N, Hori S, Oku Y. Plasma leptin levels of elite endurance runners after heavy endurance training. J. Physiol. Anthropol. Appl. Human Sci. 2005;24(6):573-8. DOI: 10.2114/jpa.24.573.
18. Noland RC, Baker JT, Boudreau SR, Kobe RW, Tanner CJ, Hickner RC, McCammon MR, Houmard JA. Effect of intense training on plasma leptin in male and female swimmers. Med. Sci. Sports Exerc. 2001;33(2):227-31. DOI: 10.1097/00005768-200102000-00009.
19. Bouassida A, Chamari K, Zaouali M, Feki Y, Zbidi A, Tabka Z. Review on leptin and adiponectin responses and adaptations to acute and chronic exercise. Br. J. Sports Med. 2010;44(9):620-30. DOI: 10.1136/bjsm.2008.046151.
20. Cleare AJ, O’Keane V, Miell J. Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion. Clin. Endocrinol. 2001;55(1):113-9. DOI: 10.1046/j.1365-2265.2001.01341.x.
21. McKenzie DC. Markers of excessive exercise. Can. J. Appl. Physiol. 1999;24(1):66-73. DOI: 10.1139/h99-007.
22. Saxton JM, Donnelly AE, Roper HP. Indices of freeradical-mediated damage following maximum voluntary eccentric and concentric muscular work. Eur. J. Appl. Physiol. Occup. Physiol. 1994;68(3):189-93. DOI: 10.1007/BF00376765.
23. Tiidus PM. Radical species in inflammation and overtraining. Can. J. Physiol. Pharmacol. 1998;76(5):533-8.
24. Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos I, Chatzinikolaou A, Mitrakou A, Mastorakos G, PapassotiriouI, Taxildaris K, Kouretas D. Oxidative stress biomarkers responses to physical overtraining: implications for diagnosis. Free Radic. Biol. Med. 2007;43(6):901-10. DOI: 10.1016/j.freeradbiomed.2007.05.022.
25. Stump CS, Short KR, Bigelow ML, Schimke JM, Nair KS. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc. Natl. Acad. Sci. U.S.A. 2003;100(13):7996-8001. DOI: 10.1073/pnas.1332551100.
26. Halson SL, Jeukendrup AE. Does overtraining exist? An analysis of overreaching and overtraining research. Sports Med. 2004;34(14):967-81. DOI: 10.2165/00007256-200434140-00003.
27. Carter JR, Ray CA. Sympathetic neural adaptations to exercise training in humans. Auton. Neurosci. 2015;188:36-43. DOI: 10.1016/j.autneu.2014.10.020.
28. Christensen NJ, Galbo H. Sympathetic nervous activity during exercise. Ann. Rev. Physiol. 1983;45:139-53. DOI: 10.1146/annurev.ph.45.030183.001035.
29. Kaji Y, Ariyoshi K, Tsuda Y, Kanaya S, Fujino T, Kuwabara H. Quantitative correlation between cardiovascular and plasma epinephrine response to mental stress. Eur. J. Appl. Physiol. 1989;59(3):221-6. DOI: 10.1007/BF02386191.
30. Hynynen A, Uusitalo A, Konttinen N, Rusko H. Heart rate variability during night sleep and after awakening in overtrained athletes. Med. Sci. Sports Exerc. 2006;38(2):313-7. DOI: 10.1249/01.mss.0000184631.27641.b5.
31. Pichot V, Roche F, Gaspoz JM, Enjolras F, Antoniadis A, Minini P, Costes F, Busso T, Lacour JR, Barthélémy JC. Relation between heart rate variability and training load in middle distance runners. Med. Sci. Sports Exerc.2000;32(10):1729-36.
32. Kindermann W. Overtraining – expression of a disturbed autonomic regulation. Dtsch. Z. Sport. med. 1986;37:238-45. DOI: 10.2165/00007256-199520040-00004.
33. Hooper SL, Mackinnon LT, Gordon RD, Bachmann AW. Hormonal responses of elite swimmers to overtraining. Med. Sci. Sports Exerc. 1993;25(6):741-7. DOI: 10.1249/00005768-199306000-00015.
34. Lehmann M, Gastmann U, Petersen KG, Bachl N, Seidel A, Khalaf AN, Fischer S, Keul J. Training-overtraining: performance, and hormone levels, after a defined increase in training volume versus intensity in experienced middle- and long-distance runners. Br. J. Sports Med. 1992;26(4):233-42. DOI: 10.1136/bjsm.26.4.233.
35. Banfi G, Marinelli M, Roi GS, Agape V. Usefulness of free testosterone/cortisol ratio during a season of elite speed skating athletes. Int. J. Sports Med. 1993;14(7):373-9. DOI: 10.1055/s-2007-1021195.
36. Banfi G, Dolci A. Free testosterone/cortisol ratio in soccer: usefulness of a categorization of values J. Sports Med. Phys. Fitness. 2006;46(4):611-6.
37. Vervoorn C, Vermulst LJ, Boelens-Quist AM, Koppeschaar HP, Erich WB, Thijssen JH, de Vries WR. Seasonal changes in performance and free testosterone: cortisol ratio of elite female rowers. Eur. J. Appl. Physiol. Occup. Physiol. 1992;64(1):14-21. DOI: 10.1007/BF00376433.
38. Ribeiro LF, Lima MC, Gobatto CA. Changes in physiological and stroking parameters during interval swims at the slope of the d-t relationship J. Sci. Med. Sport. 2010;13(1):141-5. DOI: 10.1016/j.jsams.2008.10.001.
39. Kirwan JP, Costill DL, Flynn MG, Mitchell JB, Fink WJ, Neufer PD, Houmard JA. Physiological responses to successive days of intense training in competitive swimmers. Med. Sci. Sports Exerc. 1988;20(3):255-9. DOI: 10.1249/00005768-198806000-00007.
40. Meeusen R, Piacentini MF, Busschaert B, Buyse L, De Schutter G, Stray-Gundersen J. Hormonal responses in athletes: the use of a two bout exercise protocol to detect subtle differences in (over)training status. Eur. J. Appl. Physiol. 2004;91(2-3):140-6. DOI: 10.1007/s00421-003-0940-1.
41. Cadegiani FA, Kater CE. Hormonal aspects of overtraining syndrome: a systematic review. BMC Sports Sci. Med. Rehabil. 2017;9(14):1-15. DOI 10.1186/s13102-017-0079-8.
42. Fry RW, Morton AR, Keast D. Overtraining in athletes. An update. Sports Med. 1991;12(1):32-65. DOI: 10.2165/00007256-199112010-00004.
43. Fry AC, Kraemer WJ, Van-Borselen F, Lynch JM, Marsit JL, Roy EP, Triplett NT, Knuttgen HG. Performance decrements with high-intensity resistance exercise overtraining. Med. Sci. Sports Exerc. 1994;26(9):1165-73. DOI: 10.1249/00005768-199409000-00015.
44. Robson PJ. Elucidating the unexplained underperformance syndrome in endurance athletes: the interleukin-6 hypothesis. Sports Med. 2003;33(10):771-81. DOI: 10.2165/00007256-200333100-00004.
45. Smith LL. Cytokine hypothesis of overtraining: a physiological adaptation to excessive stress? Med. Sci. Sports Exerc.2000;32(2):317-31. DOI: 10.1097/00005768-200002000-00011.
46. Smith LL. Overtraining, excessive exercise, and altered immunity: is this a T helper-1 versus T helper-2 lymphocyte response? Sports Med. 2003;33(5):347-64. DOI: 10.1097/JSM.0b013e31827ee6d5.
47. Smith DJ, Roberts D. Effects of high volume and/or intense exercise on selected blood chemistry parameters. Clin. Biochem. 1994;27(6):435-40. DOI: 10.1016/0009-9120(94)00055-Z.
48. Hu M, Lin W. Effects of exercise training on red blood cell production: implications for anemia. Acta Haematol. 2012;127(3):156-64. DOI: 10.1159/000335620.
49. Casoni I, Borsetto C, Cavicchi A, Martinelli S, Conconi F. Reduced hemoglobin concentration and red cell hemoglobinization in Italian marathon and ultramarathon runners. Int. J. Sports Med. 1985;6(3):176-9. DOI: 10.1055/s-2008-1025835.
50. Friman G, Illbäck NG. Acute infection: metabolic responses, effect on performance, interaction with exercise, and myocarditis. Int. J. Sports Med. 1998;19(3):172-82. DOI: 10.1055/s-2007-971990.
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For citations:
Dikunets M.A., Dudko G.A., Shachnev E.N., Myakinchenko E.B., Lyang O.V. Development of overtraining syndrome: survey of hypotheses. Sports medicine: research and practice. 2019;9(2):5-14. (In Russ.) https://doi.org/10.17238/ISSN2223-2524.2019.2.5
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