The severity and dynamics of changes in the serum concentration of biochemical markers of muscle tissue damage in an experienced ultramarathon runner after overcoming a distance of 165 km against the background of continuing physical activity
https://doi.org/10.47529/2223-2524.2023.2.7
Abstract
Purpose: to determine the severity and dynamics of changes in the concentration of biochemical markers of muscle tissue damage in the blood serum of an experienced ultramarathon runner after overcoming a distance of 165 kilometers.
Materials and methods: measurement of serum concentrations of markers of muscle tissue damage (aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), creatine kinase MB (CK-MB), myoglobin) in serum before and 16 and 144 hours after ultramarathon in an experienced runner (age 36, height 186 cm, weight 76 kg, body mass index 21.96).
Results: 16 hours after the end of the race, extremely high levels of AST, ALT, CK, CK-MB and myoglobin were observed, the combination of which indicates severe rhabdomyolysis. After 144 hours, a decrease in the level of all markers of muscle tissue damage, including myoglobin, was noted, however, they continued to remain significantly higher than the reference values. At the same time, the athlete did not have any significant pathological symptoms, and he continued to train in the recovery mode.
Conclusion: ultramarathon races lead to significant muscle damage, which can lead to rhabdomyolysis. Its severity may not correlate with any significant clinical manifestations.
About the Authors
E. N. Bezuglov
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Eduard N. Bezuglov, Ph.D. (Medicine), Chairman of the Medical Committee of the RFU, Head of the Medical Staff of PFC CSKA, Head of the High Performance Sports Laboratory, Sechenov First Moscow State Medical University, Russia, 125252, Moscow, 3rd Peschanaya str., 2A building 2; Associate Professor of the Department of Sports Medicine and Medical Rehabilitation, Sechenov First Moscow State Medical University, Russia, 119435, Moscow, Bolshaya Pirogovskaya str., 2 building 9
M. S. Shoshorina
Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
Maria S. Shoshorina, 1st year resident, Department of Sport Medicine and Medical Rehabilitation, Sechenov First Moscow State Medical University, Russia, 119435, Moscow, Bolshaya Pirogovskaya str., 2 building 9
O. B. Talibov
Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Oleg B. Talibov, Ph.D. (Medicine), member of the RFU medical committee, Associate Professor of the Department of Therapy, Clinical Pharmacology and Emergency Medicine, A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Russia, 127206, Moscow, Vucheticha str., 21
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Review
For citations:
Bezuglov E.N., Shoshorina M.S., Talibov O.B. The severity and dynamics of changes in the serum concentration of biochemical markers of muscle tissue damage in an experienced ultramarathon runner after overcoming a distance of 165 km against the background of continuing physical activity. Sports medicine: research and practice. 2023;13(2):13-17. (In Russ.) https://doi.org/10.47529/2223-2524.2023.2.7
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