Vaccination as an immune system status optimization tool for the high-performance sports: review

Objective: consideration of the importance of vaccination as a preventive measure of support the athlets immunne system in conditions of extreme physical exertion and increased epidemic risks.

Materials and methods: analysis of local and foreign dates of immunocorrection and vaccination problems.

Results: the presented review provides an integral assessment of the transitory immunosuppression, developing by the intensive training and competitive activities — exercise-induced immunosuppression. These dates described as an “open window” syndrome and characterized by an increased risk of viral and/or bacterial infection with predominant damage of the upper respiratory tract and gastrointestinal tract. Widespread immunoprophylaxis provides an effective and relatively safe method of infectious control at risk groups including athletes.

Conclusion: Vaccines of National Immunization Schedule and Epidemiological Immunization Schedule provide complex impact to the athletes immune status in wide variety of physical and psychological stresses. Vaccination increases the ability of specific and nonspecific resistance to infections that provide significant prevention of the “open window” syndrome.

1. Schwellnus M., Soligard T., Alonso J.M., Bahr R., Clarsen B., Dijkstra H.P., et al. How much is too much? (Part 2). International Olympic Committee consensus statement on load in sport and risk of illness. Br, J, Sports Med. 2016;50(17):1043–1052. https://doi.org/10.1136/bjsports-2016-096572

2. Suzdal’nitskii R.S., Levando V.A. New approaches to understanding of sports stress immune deficiency. Teoriya i praktika fizicheskoi kultury = Theory and Practice of Physical Culture. 2003;(1):18–22 (In Russ.).

3. Colbey C., Cox A.J., Pyne D.B., Zhang P., Cripps A.W., West N.P. Upper Respiratory Symptoms, Gut Health and Mucosal Immunity in Athletes. Sports Med. 2018;48(Suppl 1):65–77. https://doi.org/10.1007/s40279-017-0846-4

4. Gavrilova E.A., Kobrin V.G. Odontogenic focus in sports. St. Petersburg: Welcome Publ.; 2005 (In Russ.).

5. Makarova G.A., Loktev S.A. Trainer’s Medical Handbook. 2th ed. Moscow: Sovetskii sport Publ.; 2006 (In Russ.).

6. Jaworski C.A., Pyne D.B. Upper respiratory tract infections: Considerations in adolescent and adult athletes [internet]. UpToDate, Inc. 2021. Available at: https://www.medilib.ir/uptodate/show/13806

7. Graevskaya N. D., Dolmatova T. I. Sports medicine. Course of lectures and practical exercises. P. 2. Moscow: Sovetskii sport Publ.; 2004 (In Russ.).

8. Tsygan V.N., Stepanov A.V., Mokeeva E.G., Knyazkin I.V., Kim A.F., Akperov E.K. Immunorehabilitation of athletes. St. Petersburg: SpecLit Publ.; 2005 (In Russ.).

9. Gavrilova E.A. Stress immunodeficiency in athletes. Moscow: Sovetskii sport Publ.; 2009 (In Russ.).

10. Tsygan V.N., Skalnyi A.V., Mokeeva E.G. Sport. Immunity. Nutrition. St. Petersburg: ELBI-SPb Publ.; 2012 (In Russ.).

11. Alpatov S.P. Immunomodulators in the medical support of highly qualified wrestlers [dissertation]. Moscow; 2013 (In Russ.).

12. Novikov D.K., Novikov P.D., Titova N.D. Immunocorrection, immunoprophylaxis, immunorehabilitation. Vitebsk: Vitebsk State Medical University; 2006 (In Russ.).

13. Mikirtichan G.L. From the history of vaccination: vaccination against smallpox. Rossiiskiy pediatricheskiy zhurnal = Russian pediatric journal. 2016;19(1):55–62 (In Russ.). https://doi.org/10.18821/1560-9561-2016-19-1-55-62

14. Tatochenko V.K., Ozeretskovskii N.A. Immunoprofilaktika-2018: spravochnik. 13th ed. Moscow: Borges Publ.; 2018 (In Russ.).

15. Ghendon Yu.Z. High level of effectiveness and safety of antiviral vaccines and infair critique. Voprosy virusologii = Problems of Virology. 2013;58(6):5–13 (In Russ.).

16. Rodrigues C.M.C., Plotkin S.A. Impact of Vaccines; Health, Economic and Social Perspectives. Front. Microbiol. 2020;11:1526. https://doi.org/10.3389/fmicb.2020.01526.

17. Smith D.R. Herd Immunity. Vet. Clin. North Am. Food Anim. Pract. 2019;35(3):593–604. https://doi.org/10.1016/j.cvfa.2019.07.001

18. Gärtner B.C., Meyer T. Vaccination in elite athletes. Sports Med. 2014;44(10):1361–1376. https://doi.org/10.1007/s40279-014-0217-3

19. Onishhenko G.G., ed. Ensuring sanitary and epidemiological well-being during the preparation and holding of the summit АTEHS-2012. Novosibirsk: Nauka Publ.; 2013 (In Russ.).

20. Onishchenko G.G., Kuz’kin B.P., Rakitin I.A., Bashketova N.S., Korzhaev Yu.N., Grechaninova T.A., et al. Sanitary-Epidemiological Welfare Provision in the Preparations to and Management of the “G-20” Summit in Saint-Petersburg, 2013. Problemy Osobo Opasnykh Infektsii = Problems of Particularly Dangerous Infections. 2013;(4):5–10 (In Russ.).

21. Dudley M.Z., Halsey N.A., Omer S.B., Orenstein W.A., O’Leary S.T., Limaye R.J., Salmon D.A. The state of vaccine safety science: systematic reviews of the evidence. Lancet Infect Dis. 2020;20(5):e80–e89. https://doi.org/10.1016/S1473-3099(20)30130-4

22. Pandolfi F., Franza L., Todi L., Carusi V., Centrone M., Buonomo A., et al. The Importance of Complying with Vaccination Protocols in Developed Countries: “Anti-Vax” Hysteria and the Spread of Severe Preventable Diseases. Curr. Med. Chem. 2018;25(42):6070–6081. https://doi.org/10.2174/0929867325666180518072730

23. Watanabe M., Nagai M. Acellular pertussis vaccines in Japan: past, present and future. Expert Rev. Vaccines. 2005;4(2):173–184. https://doi.org/10.1586/14760584.4.2.173

24. Chistiakova G.G., Filatov N.N., Korzhenkova M.P., Solodovnikov Iu.P., Lytkina I.N., Maksimova N.M., et al. A large-scale epidemic of diphtheria in Moscow in recent years: patterns of development. Zh. Mikrobiol. Epidemiol. Immunobiol. 2001;(1):18–21.

25. Akhmadov T.Z. To the question of formation and development ofsanitary-epidemiological service of the chechen republic in 1920 and 2000. Zdorov’e naseleniya i sreda obitaniya = Public Health and Life Environment — PH&LE. 2014;(5):8–10 (In Russ.).

26. Matz A.N., Cheprasova E.V. Anti-vaccine skepticism as a social and psychological phenomenon. Epidemiologiya i Vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention. 2014;5(78):111–115 (In Russ.).

27. Kaliuzhnaia T.A., Fedoseenko M.V., Namazova-Baranova L.S., Gaivoronskaya A.G., Shakhtakhtinskaya F.C., Tkachenko N.E., et al. Overcoming ‘Anti-Vaccination Scepticism’: Seeking a Solution to the Situation. Pediatric pharmacology. 2018;15(2):141–148. (In Russ.) https://doi.org/10.15690/pf.v15i2.1871

28. Uthayakumar D., Paris S., Chapat L., Freyburger L., Poulet H., De Luca K. Non-specific Effects of Vaccines Illustrated Through the BCG Example: From Observations to Demonstrations. Front. Immunol. 2018;(9):2869. https://doi.org/10.3389/fimu.2018.02869

29. Di Pasquale A., Bonanni P., Garçon N., Stanberry L.R., El-Hodhod M., Tavares Da Silva F. Vaccine safety evaluation: Practical aspects in assessing benefits and risks. Vaccine. 2016;34(52):6672–6680. https://doi.org/10.1016/j.vaccine.2016.10.039

30. WHO Programme for International Drug Monitoring [internet]. Available at: https://who-umc.org/about-the-who-programme-for-international-drug-monitoring/

31. Spencer J.P., Trondsen Pawlowski R.H., Thomas S. Vaccine Adverse Events: Separating Myth from Reality. Am. Fam. Physician. 2017;95(12):786–794.

32. Metodicheskie rekomendacii po vyjavleniju, rassledovaniju i profilaktike pobochnyh projavlenij posle immunizacii. Ministry of Health of Russian Federation. 12.04.2019 [internet]. Available at: https://www.garant.ru/files/4/9/1299194/mr.rtf (In Russ.).

33. Stern P.L. Key steps in vaccine development. Ann. Allergy Asthma Immunol. 2020;125(1):17–27. https://doi.org/10.1016/j.anai.2020.01.025

34. Reddy S., Chitturi C., Yee J. Vaccination in Chronic Kidney Disease. Adv. Chronic Kidney Dis. 2019;26(1):72–78. https://doi.org/10.1053/j.ackd.2018.10.002

35. Dos Santos G., Tahrat H., Bekkat-Berkani R. Immunogenicity, safety, and effectiveness of seasonal influenza vaccination in patients with diabetes mellitus: A systematic review. Hum. Vaccin. Immunother. 2018;14(8):1853–1866. https://doi.org/10.1080/21645515.2018.1446719

36. Stratton K., Ford A., Rusch E., Clayton E.W., eds. Adverse Effects of Vaccines: Evidence and Causality. Washington (DC): National Academies Press (US); 2011. https://doi.org/10.17226/13164

37. Walsh N.P., Gleeson M., Shephard R.J., Gleeson M., Woods J., Bishop N.C., et al. Position statement. Part one: immune function and exercise. Exerc. Immunol. Rev. 2011;17:6–63.

38. Hackney A.C. Clinical management of immunosuppression in athletes associated with exercise training: sports medicine considerations. Acta Med. Iran. 2013;51(11):751–756. PMID: 24390943.

39. Stenger T., Ledo A., Ziller C., Schub D., Schmidt T., Enders M., et al. Timing of Vaccination after Training: Immune Response and Side Effects in Athletes. Med. Sci. Sports Exerc. 2020;52(7):1603–1609. https://doi.org/10.1249/MSS.0000000000002278

40. Pascoe A.R., Fiatarone Singh M.A., Edwards K.M. The effects of exercise on vaccination responses: a review of chronic and acute exercise interventions in humans. Brain Behav. Immun. 2014;39:33–41. https://doi.org/10.1016/j.bbi.2013.10.003

41. Boston C.D., Bryan J.J. Immunizations in Athletes. Sports Health. 2018;10(5):427–433. https://doi.org/10.1177/1941738118788279

42. Trabacchi V., Odone A., Lillo L., Pasquarella C., Signorelli C. Immunization practices in athletes. Acta Biomed. 2015;86(2):181–188.

43. Den Hartog G., van Binnendijk R., Buisman A.M., Berbers G.A.M., van der Klis F.R.M. Immune surveillance for vaccine-preventable diseases. Expert. Rev. Vaccines. 2020;19(4):327–339. https://doi.org/10.1080/14760584.2020.1745071

44. Tetanus vaccines: WHO position paper — February 2017. Wkly Epidemiol. Rec. 2017;92(6):53–76.

45. Parimalanathan V., Joy M., Van Dam P.J., Fan X., de Lusignan S. Association between Influenza Vaccine Administration and Primary Care Consultations for Respiratory Infections: Sentinel Network Study of Five Seasons (2014/2015-2018/2019) in the UK. Int. J. Environ. Res. Public Health. 2021;18(2):523. https://doi.org/10.3390/ijerph18020523

46. Mirsaeidi M., Schraufnagel D.E. Pneumococcal vaccines: understanding centers for disease control and prevention recommendations. Ann. Am. Thorac. Soc. 2014;11(6):980–985. https://doi.org/10.1513/AnnalsATS.201401-042CME

47. Arvas A. Vaccination in patients with immunosuppression. Turk Pediatri Ars. 2014;49(3):181–185. https://doi.org/10.5152/tpa.2014.2206

48. Jackson L.A., Benson P., Sneller V.P., Butler J.C., Thompson R.S., Chen R.T., et al. Safety of revaccination with pneumococcal polysaccharide vaccine. JAMA. 1999;281(3):243–248. https://doi.org/10.1001/jama.281.3.243