Evaluation of adaptive reserve of the vascular system of the abdominal cavity in healthy children and children with cystic fibrosis

Abstract

Objective: to develop the methodology to assess the adaptive reserve of the vascular system of the abdominal cavity in children based on the determination of hemodynamic parameters in abdominal arteries and veins in the dynamics of the functional tests. Materials and methods: the study included 48 healthy children and 33 children with a mixed form of cystic fibrosis from 4 to 17 years old. Doppler method determined the parameters of blood circulation in the abdominal vessels (abdominal segment of the aorta, celiac trunk, superior mesenteric, common hepatic, the splenic artery, the lower hollow, portal, and splenic vein). Adaptive reserve of the vascular system was assessed using postprandial and respiratory testes. Results: eating and breath holding in healthy children caused a dilatation of the abdominal vessels and a significant increase in volumetric blood flow velocity. In the presence of liver damage, a decrease of adaptive reserve of regional hemodynamics of the abdominal cavity was registered. The main changing was a decrease in the degree of physiological dilation of the abdominal vessels and the lack of adequate growth of the values of volumetric blood flow velocity after performing the functional tests. Conclusions: reduction of adaptive reserve of the vascular system of the abdomen is an early sign of liver injury in cystic fibrosis and precedes the appearance of structural defects of the body.