Objective: to evaluate the frequency of occurrence of polymorphisms rs1815739 (ACTN3 gene), rs2016520 (PPARD gene), rs1042713 (ADRB2 gene), rs1799945 (HFE gene) in athletes of high­performance sports.

Materials and methods: genotyping was performed using allele­specific amplification with real­time detection of the results and using TaqMan probes.

Results: a higher frequency of alleles associated with endurance was found: the t allele of the rs1815739 polymorphism (ACTN3 gene), the g allele of the rs2016520 polymorphism (PPARD gene), the g allele of the rs1042713 polymorphism (ADRB2 gene), and the g allele of the rs1799945 polymorphism (HFE gene) in athletes of game sports.

Conclusion: the results of genotyping of polymorphisms associated with endurance in the examined athletes showed a higher frequency of occurrence than in the population as a whole.

Objective: to determine the content of hormones, as well as some macro- and microelements in athletes-wrestlers outside the period of competition and active training.

Materials and methods: the study involved 66 athletes-wrestlers and 107 students involved in sports professionally. The level of hormones and vitamin D was determined by the ELISA method. To analyze the content of macro- and microelements, the subjects were cut off a lock of hair from the back of the head in an amount of at least 0.1 g. The studies were carried out on an ICP-MS Agilent 7900 mass spectrometer.

Results: levels of cortisol, TSH and T4 are higher, and levels of testosterone, T3 and vitamin D are lower in athletes compared to the control group. An increase in the content of sodium, calcium, potassium, magnesium, cobalt and a decrease in iodine were revealed in fighters from those who were not involved in sports professionally.

Conclusion: the data obtained indicate an imbalance in the work of the body’s endocrine systems and impaired adaptation to stress. It is known that the determination of the hormonal status is used to assess the adaptation, the revealed changes in the indicators of vitamin D, macro- and microelements, allow the study of these indicators in order to prevent the syndrome of overtraining of athletes, to maintain and improve sports performance.

Objective: to determine the state of dental hard tissues and saliva parameters changing in competitive swimmers, before and after a 2­hour training session in the chlorinated water swimming pool.

Materials and methods: saliva parameters of competitive swimmers trained in the sport club “Grifon”, city of St. Petersburg, Russia (n = 21), age of participants 18.1 ± 3.5 years, qualifications (1 category­Master of Sports) and track and field athletes of the sports schools “Nevsky district” and “Orlyonok”, city of St. Petersburg, Russia (n = 18), age of participants 18.80 ± 4.54 years, qualifications (1 category — Master of Sports), have been analyzed by various tests include a study of calcium (Ca), phosphorus (P), fluorine (F) levels, and pH before and after training sessions. All athletes in the experimental and control groups have passed an examination by dentist, including: examination of the oral cavity with the determination of the KPU index (the sum of carious, filled and removed permanent teeth in the subject), examination of the most common places of occurrence of dental enamel erosion (medical binoculars) and filling out specially designed questionnaires.

Results: there was a tendency to decrease of the average saliva pH in competitive swimmers’ group after a training session, varying from 6.9 ± 0.1 (before training) to 6.5 ± 0.1 (after training) (p > 0.05). In track and field athletes, saliva pH did not change significantly (7.1 ± 0.2 before training and 7.0 ± 0.1 after training) (p < 0.05). The competitive swimmers showed a statistically significant increase in Calcium (Ca) levels (1.25 ± 0.15 mmol/L before exercise and 1.56 ± 0.11 mmol/L after exercise) and Fluorine (F) (0.0010 ± 0.0003 mmol / L before exercise and 0.0090 ± 0.0004 mmol / L after training session) in saliva. The Phosphorus (P) level in saliva was significantly reduced after the training session (from 6.09 ± 0.39 to 3.89 ± 0.46 mmol / L) (p > 0.05). In track and field athletes, there were no significant changes in Ca, F and P levels before and after a training session. As a result of the dentist’s examination, competitive swimmers were found to have 3 athletes (14.3 %) with lesions of the teeth enamel, corresponding to dental erosion and caused by localized demineralization. In the control group of athletes, no such pathologies were revealed.

Conclusion: discovered saliva parameters changing in competitive swimmers (decrease in free salivation, pH level, and increase in the level of Ca and F in saliva) can contribute to the demineralization of tooth enamel. Timely and controlled use of fluorides (as part of mouth rinses, application gels, fluoride varnishes), regular preventive dental examinations, in order to prevent the loss of mineral composition of the teeth when swimming in chlorinated pools, will minimize the risk of staining and dental enamel erosions.

Purpose of the study: to study the effect of Vitrum in combination with adaptogens on immunological reactivity and physical performance in athletes under conditions of intense training.

Materials and methods: 4 groups of athletes, 10 people in each, went through a cycle of intensive training according to a specially developed methodology. Group I took Vitrum, group II — Vitrum + Eleutherococcus extract, group III — Vitrum + ginseng tincture. Group IV — ascorbic acid and was used as a control. Blood for analysis was taken from the cubital vein before and after 28 days of drug administration. Indicators of immunological reactivity were determined by modern laboratory methods. Physical performance was determined by the index of the Harvard step test (IHST) and the PWC170 test.

Results: the use of Vitrum in combination with adaptogens promotes a significant increase in the parameters of humoral (increase in IgA by 32–40 %, IgM by 28–43 %, IgG by 9–14 %) and cellular (increasing the completeness of phagocytosis by 9–37 % immunity.

Conclusion: intake of Vitrum in combination with adaptogens was accompanied by a significant increase in nonspecific immunity and increased the level of fitness.

According to some literature data, during voluntary long-term breath holding (BH), the heart rate (HR) increases, and according to others, it decreases.

Objective: to determine the psychophysiological parameters that cause a change in HR during BH in athletes with different resistance to respiratory hypoxia.

Materials and methods: HR at BH was studied in 14 beginner athletes, 15 basketball players and 12 swimmers-divers. Duration of BH was recorded. The HR was recorded on a heart rate monitor. After recording an electrocardiogram, the standard deviation of the duration of cardiac cycles was calculated. The arterial oxygen saturation was measured with a pulse oximeter. The statistically significant values of the correlation coefficient (r) were ≥0.33 with p < 0.05.

Results: it was found that out of 41 sportsmen, HR increased by more than 5 % in 4, changed insignificantly in 7 and decreased by less than 5 % in 30. Beginner athletes had tachycardia, and BH was quickly interrupted by an imperative inhalation. The saturation of arterial blood with oxygen did not change and did not affect the change in HR. The decrease in heart rate in swimmers-divers in comparison with the other two groups of people examined was statistically significant (p < 0.05). The duration of BH had a direct correlation (r = 0.5) with bradycardia in these people. The duration of BH caused (r = 0.8) hypoxia, the value of which also directly influenced (r = 0.38) the severity of bradycardia. In addition, the decrease in HR depended on high HR (r = 0.36) and low HR variability (r = 0.38) before BH.

Conclusion: tachycardia occurs in beginner athletes who experience discomfort with BH. Bradycardia occurs in sportsmen with a long-term BH setting without discomfort. Sympathicotonia in the prelaunch state predetermines the severity of bradycardia in BH. The duration of BH and the resulting hypoxia provide the occurrence of bradycardia.

Objective: to assess the actual nutrition of football players according to their personal daily energy expenditures.

Materials and methods: the study of the actual nutrition of the athletes of the division II football team was carried out at the training camp. A total of 23 athletes participated in this study, including 3 goalkeepers, 3 attackers, 7 defenders, and 10 midfielders. The average age of the team is 24.2 ± 0.3 years. The collection of information on actual nutrition was carried out in two ways: using a 24­-hour dietary recall method for at least 2 days and frequency meal analysis method. The amount of food consumed was determined using lists that include information on portions and meals. The chemical composition and energy value of the diets were evaluated using two databases of Russian food composition tables. Energy expenditures were calculated using the heart rate monitoring.

Results: study results show that the energy value of football players’daily ration averaged 2560.6 ± 150.6 kcal, while the average energy expenditure was 4100.0 ± 51.3 kcal/day. The study revealed high levels of fat (42 %) and EFA (14,8 %) consumption in terms of dietary intake, while the proportion of energy from carbohydrates was insufficient, only 43.1 %. Moreover, the athletes obtain 17.5 % of their energy intake from added sugar. In addition, the study revealed insufficient intake of vitamins A and B₁ among 86 % of athletes, B₂ — 79 %, niacin — 65 % and vitamin C — 72 %. Analysis of the daily intake of minerals revealed an insufficient calcium content in the 38 % of football players’ diets, magnesium — in 62 %, and low calcium to phosphorus ratio — in 44 % of diets.

Conclusion: the data obtained showed a nutritional imbalance of the football players, both in intake of calories and in the nutrient consumption. 50 % of the athletes surveyed have insufficient protein intake, 80 % of those surveyed had high levels of fat and EFA consumption. The study revealed a high prevalence of genetic polymorphism associated with impaired bone mineralization. Considering that high performance sport requires a special approach to each athlete, taking into account his individual needs, the functional state of the body, genetic characteristics, the training phases, each athlete needs a personal diet, which will include certain products, vitamin and mineral supplements, and will definitely be adjusted in the future.

The review presents an urgent problem of modern sports medicine — the development and inclusion of new nutritive and metabolic food products in the treatment of athletes with injuries and diseases of the musculoskeletal system. The analysis of the main etiological factors of the musculoskeletal disorders in athletes is presented. The study of the anatomical, histological and functional features of the bone-cartilaginous structures in athletes made it possible to establish the priority macro- and micronutrients, which should be the basis in modern specialized and functional food products. Brief composition characteristics of the new canned food “Enmit-beef” and dry protein concentrate “Ostov” (for the drink preparation) are presented. The preliminary results of the use of these functional meat-based products indicate their effectiveness in rehabilitation and treatment of athletes with musculoskeletal disorders.

Objective: to analyze how eating habits depend on age and gender among people aged 40 and over engaged in sports (athletics, participation in 10 km or more road running races).

Materials and methods: the information about eating habits was obtained through questionnaires of athletes aged 40 and over, participating in 10 km or more road running races. 1649 questionnaires were analyzed. The analysis was carried out in three age groups: 40–49 years old, 50–59 years old, and 60 years old and over.

Results: more than half of men and a third of women do not follow any principles in organizing their diet. The most common habit, regardless of gender, is eating three or more times a day. The largest amount of food is consumed in the middle of the day and in the afternoon. Most of the respondents try to eat at the same time of the day, when there is such an opportunity. Snacking between main meals is a widespread habit, especially among women. Despite the fact that the majority of men and 30 % of women often consume flour products and products containing sugar, they are not overweight.

Conclusion: most of the athletes aged 40 and over do not aim to follow a diet or improve nutrition.

Objective: to determine the level of awareness of the doping issues among adolescents aged 10–19 years who are engaged in amateur sports as a part of high performance sport.

Materials and methods: a special survey of 106 respondents was conducted to assess attitudes towards doping and the level of awareness in anti-doping issues. The average age of the respondents was 17.33 ± 1.54 years.

Results: despite the fact that 96 % of the respondents stated that they know what doping is, generally, there is a low level of awareness among young athletes in anti-doping issues. One fourth of the respondents can justify the use of doping, only 13.2 % of adolescents believe that winning a competition with the use of doping can be considered as a well-deserved victory. More than 56 % of the respondents do not warn medical staff that they are athletes, only 32.1 % of adolescents are interested in whether medications prescribed or taken by themselves are included in the prohibited list. The study found that the main sources of information on anti-doping rules for adolescent athletes are television (64.1 %) and specialized websites (47.2 %).

Conclusion: the study results revealed the need to popularize information on anti-doping issues. Educational programs should be carried out taking into account the psychological and emotional characteristics of adolescents and include actively promoting doping awareness both using conventional media and new media resources, such as the Internet and social networks.

The article presents an overview of the literature on modern correction methods of an underactive bladder in spinal cord injury patients. The article provides data on the effectiveness of treatment and possible complications.

There is no data on the prevalence of endocrine disorders in young elite athletes in Russia.

Objective: to assess the prevalence of endocrine pathologies and their structure in children and adolescents involved in elite sport.

Materials and methods: the study included data from outpatient records of members of national sports teams, who underwent special medical examination. The data of a random sample of 1081 outpatient cards of young athletes, for 26 sports, were analyzed.

Results: we found a high prevalence of endocrine pathology (18.6 %) in children and adolescents involved in high-performance sports. Thyroid diseases are most the most frequent in young athletes (in 57.3 % of cases). On second place is obesity (12.3 %). The frequency of weight deficiency and short stature is 8.4 % each. Autoimmune thyroiditis occupies a leading place in the structure of thyroid pathology in young elite athletes. Subclinical hypothyroidism takes the second place, and nodular goiter — the third place.

Conclusion: young elite athletes are characterized by a high frequency of endocrine pathology, the leading place in which is occupied by thyroid diseases. It is necessary to further studies aimed at assessing the mechanisms of hormonal adaptation in elite young athletes to assess their impact on the development of the child and the correct interpretation of the hormonal profile obtained during a special medical examination.

The reasons and mechanisms of development of jetlag in athletes are presented. Organizational solutions of maladaptation prevention are proposed. Proposals for preparation for flight, adjustments for arrival of both medical and pedagogical nature are looked at.